| Redmile Group, LLC | Institution | 14.549.768 | 8,88% | US$ 79,30M | 2026-03-31 |
| BlackRock, Inc. | Institution | 10.938.509 | 6,68% | US$ 59,61M | 2026-03-31 |
| FMR LLC | Institution | 10.635.576 | 6,49% | US$ 57,96M | 2026-03-31 |
| Alerce Investment Management L.P. | Institution | 8.921.397 | 5,45% | US$ 48,62M | 2025-11-21 |
| BVF Partners L.P. | Institution | 8.698.173 | 5,31% | US$ 47,41M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.919.255 | 4,22% | US$ 37,71M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 6.600.000 | 4,03% | US$ 35,97M | 2025-04-21 |
| Vanguard Capital Management, LLC | Institution | 5.956.589 | 3,64% | US$ 32,46M | 2026-03-31 |
| Bain Capital Life Sciences Investors, LLC | Institution | 5.212.674 | 3,18% | US$ 28,41M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 5.157.290 | 3,15% | US$ 28,11M | 2026-03-31 |
| MAK Capital One, LLC | Institution | 4.724.043 | 2,88% | US$ 25,75M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 4.644.823 | 2,83% | US$ 25,31M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 4.300.000 | 2,62% | US$ 23,44M | 2026-03-31 |
| Bank of America Corporation | Institution | 4.206.398 | 2,57% | US$ 22,92M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 4.172.424 | 2,55% | US$ 22,74M | 2026-03-31 |
| Artal Group S.A. | Institution | 3.958.646 | 2,42% | US$ 21,57M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 3.886.909 | 2,37% | US$ 21,18M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 3.449.121 | 2,11% | US$ 18,80M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 3.399.850 | 2,08% | US$ 18,53M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.377.823 | 2,06% | US$ 18,41M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 3.114.314 | 1,90% | US$ 16,97M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 2.948.090 | 1,80% | US$ 16,07M | 2026-03-31 |
| Morgan Stanley | Institution | 2.684.106 | 1,64% | US$ 14,63M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 2.500.000 | 1,53% | US$ 13,63M | 2026-03-31 |
| Woodline Partners LP | Institution | 2.337.137 | 1,43% | US$ 12,74M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 2.331.761 | 1,42% | US$ 12,71M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.871.795 | 1,14% | US$ 10,20M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.483.090 | 0,91% | US$ 8,08M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.376.588 | 0,84% | US$ 7,50M | 2026-03-31 |
| Y-Intercept (Hong Kong) Limited | Institution | 1.319.913 | 0,81% | US$ 7,19M | 2026-03-31 |
| Tetragon Partners UK LLP | Institution | 1.292.455 | 0,79% | US$ 7,04M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.238.678 | 0,76% | US$ 6,75M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.226.601 | 0,75% | US$ 6,68M | 2026-03-31 |
| Satter Medical Technology Partners, L.P. | Institution | 1.147.738 | 0,70% | US$ 6,26M | 2025-11-21 |
| Charles Schwab Investment Management, Inc. | Institution | 1.102.445 | 0,67% | US$ 6,01M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.086.902 | 0,66% | US$ 5,92M | 2026-03-31 |