| FMR LLC | Institution | 16.630.456 | 14,96% | US$ 270,74M | 2026-03-31 |
| BlackRock, Inc. | Institution | 8.828.826 | 7,94% | US$ 143,73M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 8.284.882 | 7,45% | US$ 134,88M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 8.284.882 | 7,45% | US$ 134,88M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 6.243.812 | 5,62% | US$ 101,65M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 5.650.000 | 5,08% | US$ 91,98M | 2025-11-10 |
| Commodore Capital LP | Institution | 5.650.000 | 5,08% | US$ 91,98M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 4.986.073 | 4,48% | US$ 81,17M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.717.709 | 4,24% | US$ 76,80M | 2025-06-24 |
| Saturn V Capital Management LP | Institution | 4.349.885 | 3,91% | US$ 70,82M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 4.141.575 | 3,72% | US$ 67,42M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 3.560.764 | 3,20% | US$ 57,97M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 3.190.645 | 2,87% | US$ 51,94M | 2026-03-31 |
| Mr. Joshua Cohen | Insider | 3.111.261 | 2,80% | US$ 50,65M | 2026-03-05 |
| Mr. Justin Klee | Insider | 3.111.194 | 2,80% | US$ 50,65M | 2026-03-05 |
| Driehaus Capital Management LLC | Institution | 2.987.147 | 2,69% | US$ 48,63M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 2.777.055 | 2,50% | US$ 45,21M | 2025-12-31 |
| State Street Global Advisors, Inc. | Institution | 2.363.161 | 2,13% | US$ 38,47M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.242.398 | 2,02% | US$ 36,51M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.210.932 | 1,99% | US$ 35,99M | 2026-03-31 |
| Panacea Venture Management Co., Ltd. | Institution | 2.200.000 | 1,98% | US$ 35,82M | 2024-12-31 |
| Panacea Venture Healthcare Fund II, L.P. | Institution | 2.200.000 | 1,98% | US$ 35,82M | 2024-12-31 |
| Almitas Capital LLC | Institution | 2.122.597 | 1,91% | US$ 34,56M | 2026-03-31 |
| Morgan Stanley | Institution | 2.115.000 | 1,90% | US$ 34,43M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1.750.000 | 1,57% | US$ 28,49M | 2026-03-31 |
| Jones Hill Capital LP | Institution | 1.598.794 | 1,44% | US$ 26,03M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 1.530.000 | 1,38% | US$ 24,91M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 1.513.958 | 1,36% | US$ 24,65M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.354.929 | 1,22% | US$ 22,06M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 1.271.062 | 1,14% | US$ 20,69M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 1.267.785 | 1,14% | US$ 20,64M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.230.000 | 1,11% | US$ 20,02M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.107.271 | 1,00% | US$ 18,03M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.093.359 | 0,98% | US$ 17,80M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.000.604 | 0,90% | US$ 16,29M | 2026-03-31 |
| Barclays PLC | Institution | 970.679 | 0,87% | US$ 15,80M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 944.781 | 0,85% | US$ 15,38M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 903.192 | 0,81% | US$ 14,70M | 2026-03-31 |