| FMR LLC | Institution | 16.630.456 | 14,96% | US$ 298,52M | 2026-03-31 |
| BlackRock, Inc. | Institution | 8.828.836 | 7,94% | US$ 158,48M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 8.284.882 | 7,45% | US$ 148,71M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 8.284.882 | 7,45% | US$ 148,71M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 6.243.812 | 5,62% | US$ 112,08M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 5.650.000 | 5,08% | US$ 101,42M | 2025-11-10 |
| Commodore Capital LP | Institution | 5.650.000 | 5,08% | US$ 101,42M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 4.986.073 | 4,48% | US$ 89,50M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.717.709 | 4,24% | US$ 84,68M | 2025-06-24 |
| Saturn V Capital Management LP | Institution | 4.349.885 | 3,91% | US$ 78,08M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 3.560.764 | 3,20% | US$ 63,92M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 3.190.645 | 2,87% | US$ 57,27M | 2026-03-31 |
| Mr. Joshua Cohen | Insider | 3.111.261 | 2,80% | US$ 55,85M | 2026-03-05 |
| Mr. Justin Klee | Insider | 3.111.194 | 2,80% | US$ 55,85M | 2026-03-05 |
| Driehaus Capital Management LLC | Institution | 2.987.147 | 2,69% | US$ 53,62M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 2.777.055 | 2,50% | US$ 49,85M | 2025-12-31 |
| State Street Global Advisors, Inc. | Institution | 2.363.161 | 2,13% | US$ 42,42M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.242.398 | 2,02% | US$ 40,25M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.210.932 | 1,99% | US$ 39,69M | 2026-03-31 |
| Panacea Venture Management Co., Ltd. | Institution | 2.200.000 | 1,98% | US$ 39,49M | 2024-12-31 |
| Panacea Venture Healthcare Fund II, L.P. | Institution | 2.200.000 | 1,98% | US$ 39,49M | 2024-12-31 |
| Almitas Capital LLC | Institution | 2.122.597 | 1,91% | US$ 38,10M | 2026-03-31 |
| Morgan Stanley | Institution | 2.115.000 | 1,90% | US$ 37,96M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 1.750.000 | 1,57% | US$ 31,41M | 2026-03-31 |
| Jones Hill Capital LP | Institution | 1.598.794 | 1,44% | US$ 28,70M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 1.530.000 | 1,38% | US$ 27,46M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 1.513.958 | 1,36% | US$ 27,18M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 1.267.785 | 1,14% | US$ 22,76M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.230.000 | 1,11% | US$ 22,08M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.107.271 | 1,00% | US$ 19,88M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.000.604 | 0,90% | US$ 17,96M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 903.192 | 0,81% | US$ 16,21M | 2026-03-31 |
| Woodline Partners LP | Institution | 845.800 | 0,76% | US$ 15,18M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 800.000 | 0,72% | US$ 14,36M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 779.908 | 0,70% | US$ 14,00M | 2026-03-31 |