| Matrix Capital Management Company, LP | Institution | 15.139.707 | 11,88% | US$ 378,95M | 2026-05-05 |
| AyurMaya Capital Management Fund, LP | Institution | 15.139.707 | 11,88% | US$ 378,95M | 2026-05-05 |
| Foresite Capital Management, LLC | Institution | 15.013.334 | 11,78% | US$ 375,78M | 2026-04-01 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 7.362.035 | 5,77% | US$ 184,27M | 2026-03-30 |
| BlackRock, Inc. | Institution | 7.170.868 | 5,62% | US$ 179,49M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 6.772.595 | 5,31% | US$ 169,52M | 2026-03-31 |
| Samsara BioCapital LLC | Institution | 6.345.219 | 4,98% | US$ 158,82M | 2026-03-31 |
| Foresite Capital Fund V, L.P. | Institution | 5.702.536 | 4,47% | US$ 142,73M | 2026-04-01 |
| venBio LLC | Institution | 4.528.408 | 3,55% | US$ 113,35M | 2026-03-31 |
| Samsara Biocapital, L.P. | Institution | 4.491.731 | 3,52% | US$ 112,43M | 2026-01-09 |
| Foresite Capital Fund VI LP | Institution | 4.247.670 | 3,33% | US$ 106,32M | 2026-04-01 |
| Vanguard Capital Management, LLC | Institution | 4.032.266 | 3,16% | US$ 100,93M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 3.949.241 | 3,10% | US$ 98,85M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 3.540.998 | 2,78% | US$ 88,63M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 3.286.753 | 2,58% | US$ 82,27M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 3.202.075 | 2,51% | US$ 80,15M | 2026-03-31 |
| UBS Asset Management AG | Institution | 3.136.939 | 2,46% | US$ 78,52M | 2026-03-31 |
| Foresite Capital Opportunity Fund V, L.P. | Institution | 2.908.332 | 2,28% | US$ 72,80M | 2026-04-01 |
| Octagon Capital Advisors LP | Institution | 2.830.700 | 2,22% | US$ 70,85M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 2.386.529 | 1,87% | US$ 59,73M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2.124.408 | 1,67% | US$ 53,17M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 2.012.500 | 1,58% | US$ 50,37M | 2026-03-31 |
| SR One Capital Management, LP | Institution | 1.959.896 | 1,54% | US$ 49,06M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.918.415 | 1,50% | US$ 48,02M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.801.812 | 1,41% | US$ 45,10M | 2026-03-31 |
| Tybourne Capital Management (HK) Ltd. | Institution | 1.399.250 | 1,10% | US$ 35,02M | 2025-09-30 |
| HBM Partners Ltd. | Institution | 1.278.298 | 1,00% | US$ 32,00M | 2024-12-31 |
| Ikarian Capital, LLC | Institution | 1.213.548 | 0,95% | US$ 30,38M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.172.749 | 0,92% | US$ 29,35M | 2026-03-31 |
| Invesco Ltd. | Institution | 1.146.070 | 0,90% | US$ 28,69M | 2026-03-31 |
| Weiss Asset Management, LLC | Institution | 1.097.417 | 0,86% | US$ 27,47M | 2026-03-31 |
| Principal Global Investors, LLC | Institution | 1.058.051 | 0,83% | US$ 26,48M | 2026-03-31 |
| FMR LLC | Institution | 973.712 | 0,76% | US$ 24,37M | 2026-03-31 |
| Ally Bridge Group | Institution | 943.804 | 0,74% | US$ 23,62M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 856.061 | 0,67% | US$ 21,43M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 809.918 | 0,64% | US$ 20,27M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 800.000 | 0,63% | US$ 20,02M | 2026-03-31 |
| Voloridge Investment Management, LLC | Institution | 749.099 | 0,59% | US$ 18,75M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 712.608 | 0,56% | US$ 17,84M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 658.115 | 0,52% | US$ 16,47M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 635.389 | 0,50% | US$ 15,90M | 2026-03-31 |
| Millennium Management LLC | Institution | 606.284 | 0,48% | US$ 15,18M | 2026-03-31 |