| Pfizer Venture Investments LLC | Institution | 22.032.040 | 6,38% | US$ 45,83M | 2026-03-31 |
| BlackRock, Inc. | Institution | 19.091.095 | 5,53% | US$ 39,71M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 18.796.668 | 5,45% | US$ 39,10M | 2026-04-16 |
| TPG Capital, L.P. | Institution | 18.716.306 | 5,42% | US$ 38,93M | 2026-03-31 |
| Frazier Life Sciences Public Fund, L.P. | Institution | 16.205.306 | 4,70% | US$ 33,71M | 2026-04-16 |
| Citadel Multi-Strategy Equities Master Fund Ltd. | Institution | 10.203.329 | 2,96% | US$ 21,22M | 2025-07-09 |
| State Street Global Advisors, Inc. | Institution | 8.660.306 | 2,51% | US$ 18,01M | 2026-03-31 |
| PRIMECAP Management Company | Institution | 8.379.840 | 2,43% | US$ 17,43M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 6.921.350 | 2,01% | US$ 14,40M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 6.793.620 | 1,97% | US$ 14,13M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 5.380.902 | 1,56% | US$ 11,19M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 5.375.456 | 1,56% | US$ 11,18M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 4.124.178 | 1,19% | US$ 8,58M | 2026-03-31 |
| Woodline Partners LP | Institution | 3.501.078 | 1,01% | US$ 7,28M | 2026-03-31 |
| Patient Square Capital, LP | Institution | 3.450.000 | 1,00% | US$ 7,18M | 2026-03-31 |
| Marshall Wace LLP | Institution | 3.447.984 | 1,00% | US$ 7,17M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.322.053 | 0,96% | US$ 6,91M | 2026-03-31 |
| Citadel Securities LLC | Institution | 3.142.822 | 0,91% | US$ 6,54M | 2025-07-09 |
| Candriam, Société En Commandite Par Actions | Institution | 2.997.318 | 0,87% | US$ 6,23M | 2026-03-31 |
| Wildcat Capital Management, LLC | Institution | 2.920.787 | 0,85% | US$ 6,08M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 2.763.776 | 0,80% | US$ 5,75M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 2.725.000 | 0,79% | US$ 5,67M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 2.412.881 | 0,70% | US$ 5,02M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 2.358.843 | 0,68% | US$ 4,91M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 2.263.140 | 0,66% | US$ 4,71M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 2.242.933 | 0,65% | US$ 4,67M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 2.139.328 | 0,62% | US$ 4,45M | 2026-03-31 |
| Bank of America Corporation | Institution | 2.134.473 | 0,62% | US$ 4,44M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 2.013.508 | 0,58% | US$ 4,19M | 2026-03-31 |
| Vida Ventures, LLC | Institution | 1.798.163 | 0,52% | US$ 3,74M | 2026-03-31 |
| Vida Ventures Advisors, LLC | Institution | 1.798.163 | 0,52% | US$ 3,74M | 2026-03-31 |
| Vida Ventures III, L.P. | Institution | 1.724.137 | 0,50% | US$ 3,59M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.694.112 | 0,49% | US$ 3,52M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.604.090 | 0,46% | US$ 3,34M | 2026-03-31 |
| FMR LLC | Institution | 1.580.164 | 0,46% | US$ 3,29M | 2026-03-31 |
| Frazier Life Sciences XII, L.P. | Institution | 1.561.500 | 0,45% | US$ 3,25M | 2026-04-16 |
| Aberdeen Group Plc | Institution | 1.462.219 | 0,42% | US$ 3,04M | 2026-03-31 |
| GordonMD Global Investments LP | Institution | 1.430.000 | 0,41% | US$ 2,97M | 2026-03-31 |