| TCG Crossover Management, LLC | Institution | 10.000.000 | 9,01% | US$ 18,10M | 2026-03-31 |
| BlackRock, Inc. | Institution | 7.741.245 | 6,97% | US$ 14,01M | 2026-03-31 |
| Dr. Arnon Rosenthal | Insider | 5.717.610 | 5,15% | US$ 10,35M | 2026-03-31 |
| TCG Crossover Fund III, L.P. | Institution | 5.000.000 | 4,50% | US$ 9,05M | 2025-10-22 |
| TCG Crossover Fund II, L.P. | Institution | 5.000.000 | 4,50% | US$ 9,05M | 2025-10-22 |
| Polaris Venture Partners, Inc. | Institution | 4.853.817 | 4,37% | US$ 8,79M | 2026-03-31 |
| Polaris Venture Partners VI, L.P. | Institution | 4.585.838 | 4,13% | US$ 8,30M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 4.038.785 | 3,64% | US$ 7,31M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 3.887.200 | 3,50% | US$ 7,04M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.678.722 | 3,31% | US$ 6,66M | 2026-03-31 |
| MRL Ventures Fund LLC | Institution | 3.545.719 | 3,19% | US$ 6,42M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 3.332.835 | 3,00% | US$ 6,03M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 3.200.000 | 2,88% | US$ 5,79M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 2.935.253 | 2,64% | US$ 5,31M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 2.815.983 | 2,54% | US$ 5,10M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 2.583.542 | 2,33% | US$ 4,68M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.286.218 | 2,06% | US$ 4,14M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 2.154.361 | 1,94% | US$ 3,90M | 2026-03-31 |
| Spruce Street Capital LP | Institution | 2.101.068 | 1,89% | US$ 3,80M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 2.082.606 | 1,88% | US$ 3,77M | 2026-03-31 |
| Kynam Capital Management, LP | Institution | 2.000.000 | 1,80% | US$ 3,62M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.979.226 | 1,78% | US$ 3,58M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.865.526 | 1,68% | US$ 3,38M | 2026-03-31 |
| FMR LLC | Institution | 1.796.008 | 1,62% | US$ 3,25M | 2026-03-31 |
| Medici Capital LLC | Institution | 1.652.520 | 1,49% | US$ 2,99M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 1.351.106 | 1,22% | US$ 2,45M | 2026-03-31 |
| Euclidean Capital LLC | Institution | 1.307.858 | 1,18% | US$ 2,37M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.287.691 | 1,16% | US$ 2,33M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.279.306 | 1,15% | US$ 2,32M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 1.092.903 | 0,98% | US$ 1,98M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 1.055.192 | 0,95% | US$ 1,91M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.050.000 | 0,95% | US$ 1,90M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 908.351 | 0,82% | US$ 1,64M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 900.000 | 0,81% | US$ 1,63M | 2026-03-31 |
| Mackenzie Financial Corporation | Institution | 857.354 | 0,77% | US$ 1,55M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 787.408 | 0,71% | US$ 1,43M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 695.772 | 0,63% | US$ 1,26M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 692.256 | 0,62% | US$ 1,25M | 2026-03-31 |
| Marshall Wace LLP | Institution | 620.424 | 0,56% | US$ 1,12M | 2026-03-31 |