| Knoll Capital Management | Institution | 5.475.516 | 9,08% | US$ 9,64M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.763.887 | 6,24% | US$ 6,62M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 2.780.875 | 4,61% | US$ 4,89M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.363.742 | 3,92% | US$ 4,16M | 2026-03-31 |
| Kingdon Capital Management, L.L.C. | Institution | 2.152.315 | 3,57% | US$ 3,79M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 1.500.000 | 2,49% | US$ 2,64M | 2026-03-31 |
| Dr. Todd Brady | Insider | 1.411.610 | 2,34% | US$ 2,48M | 2026-04-13 |
| D. E. Shaw & Co., L.P. | Institution | 1.403.990 | 2,33% | US$ 2,47M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.251.652 | 2,07% | US$ 2,20M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.124.710 | 1,86% | US$ 1,98M | 2026-03-31 |
| Millennium Management LLC | Institution | 995.243 | 1,65% | US$ 1,75M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 968.891 | 1,61% | US$ 1,71M | 2026-03-31 |
| Ardsley Advisory Partners LP | Institution | 950.000 | 1,57% | US$ 1,67M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 863.187 | 1,43% | US$ 1,52M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 858.288 | 1,42% | US$ 1,51M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 807.778 | 1,34% | US$ 1,42M | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 796.816 | 1,32% | US$ 1,40M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 730.606 | 1,21% | US$ 1,29M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 624.170 | 1,03% | US$ 1,10M | 2026-03-31 |
| UBS Asset Management AG | Institution | 542.394 | 0,90% | US$ 954,61k | 2026-03-31 |
| Morgan Stanley | Institution | 480.104 | 0,80% | US$ 844,98k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 432.296 | 0,72% | US$ 760,84k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 374.812 | 0,62% | US$ 659,67k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 338.621 | 0,56% | US$ 595,97k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 286.444 | 0,47% | US$ 504,14k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 278.442 | 0,46% | US$ 490,06k | 2026-03-31 |
| Woodstock Corporation | Institution | 266.756 | 0,44% | US$ 469,49k | 2026-03-31 |
| IEQ Capital, LLC | Institution | 266.518 | 0,44% | US$ 469,07k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 266.340 | 0,44% | US$ 468,76k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 247.194 | 0,41% | US$ 435,06k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 223.537 | 0,37% | US$ 393,43k | 2026-03-31 |
| Dr. Stephen Machatha | Insider | 222.010 | 0,37% | US$ 390,74k | 2026-04-13 |
| Bank of America Corporation | Institution | 215.332 | 0,36% | US$ 378,98k | 2026-03-31 |
| Dr. Richard Douglas | Insider | 195.000 | 0,32% | US$ 343,20k | 2026-04-13 |
| Wells Fargo & Company | Institution | 189.729 | 0,31% | US$ 333,92k | 2026-03-31 |
| RBC Global Asset Management Inc. | Institution | 186.433 | 0,31% | US$ 328,12k | 2025-12-31 |
| ExodusPoint Capital Management, LP | Institution | 167.604 | 0,28% | US$ 294,98k | 2026-03-31 |
| Caption Management, LLC | Institution | 165.000 | 0,27% | US$ 290,40k | 2026-03-31 |
| Palo Alto Investors LP | Institution | 155.709 | 0,26% | US$ 274,05k | 2026-03-31 |