| BlackRock, Inc. | Institution | 5.754.957 | 9,68% | US$ 208,79M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 5.684.000 | 9,56% | US$ 206,22M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 3.364.879 | 5,66% | US$ 122,08M | 2026-03-31 |
| Lynx1 Capital Management LP | Institution | 3.013.949 | 5,07% | US$ 109,35M | 2026-04-29 |
| Lynx1 Master Fund LP | Institution | 3.013.949 | 5,07% | US$ 109,35M | 2026-04-29 |
| Farallon Healthcare Partners Master, L.P. | Institution | 2.928.459 | 4,92% | US$ 106,24M | 2025-12-31 |
| Armistice Capital LLC | Institution | 2.716.000 | 4,57% | US$ 98,54M | 2026-03-31 |
| Erste Asset Management GmbH | Institution | 2.704.900 | 4,55% | US$ 98,13M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 2.681.169 | 4,51% | US$ 97,27M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.632.316 | 4,43% | US$ 95,50M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 2.611.035 | 4,39% | US$ 94,73M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 2.493.645 | 4,19% | US$ 90,47M | 2025-08-21 |
| T. Rowe Price Group, Inc. | Institution | 1.787.523 | 3,01% | US$ 64,85M | 2026-03-31 |
| Nomura Investment Management Business Trust | Institution | 1.494.435 | 2,51% | US$ 54,22M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.467.910 | 2,47% | US$ 53,26M | 2026-03-31 |
| BNPP Asset Management Holding | Institution | 1.403.594 | 2,36% | US$ 50,92M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.344.953 | 2,26% | US$ 48,79M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 1.306.261 | 2,20% | US$ 47,39M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 1.256.080 | 2,11% | US$ 45,57M | 2026-03-31 |
| GW&K Investment Management, LLC | Institution | 1.214.901 | 2,04% | US$ 44,08M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.151.614 | 1,94% | US$ 41,78M | 2026-03-31 |
| Farallon Capital Offshore Investors II, L.P | Institution | 904.525 | 1,52% | US$ 32,82M | 2025-12-31 |
| Morgan Stanley | Institution | 891.043 | 1,50% | US$ 32,33M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 799.163 | 1,34% | US$ 28,99M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 707.224 | 1,19% | US$ 25,66M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 685.240 | 1,15% | US$ 24,86M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 672.681 | 1,13% | US$ 24,40M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 641.486 | 1,08% | US$ 23,27M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 619.613 | 1,04% | US$ 22,48M | 2026-03-31 |
| SCS Capital Management LLC | Institution | 612.850 | 1,03% | US$ 22,23M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 525.000 | 0,88% | US$ 19,05M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 509.272 | 0,86% | US$ 18,48M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 481.516 | 0,81% | US$ 17,47M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 477.032 | 0,80% | US$ 17,31M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 450.093 | 0,76% | US$ 16,33M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 450.000 | 0,76% | US$ 16,33M | 2026-03-31 |
| Marshall Wace LLP | Institution | 448.118 | 0,75% | US$ 16,26M | 2026-03-31 |
| Farallon Capital Institutional Partners, L.P. | Institution | 446.450 | 0,75% | US$ 16,20M | 2025-12-31 |