| Opaleye Management Inc. | Institution | 2.620.369 | 12,03% | US$ 15,93M | 2026-05-21 |
| Opaleye L.P | Institution | 2.530.369 | 11,62% | US$ 15,38M | 2026-05-21 |
| Solas Capital Management, LLC | Institution | 1.924.617 | 8,84% | US$ 11,70M | 2026-03-31 |
| AWM Investment Company Inc | Institution | 1.672.168 | 7,68% | US$ 10,17M | 2026-03-31 |
| Cable Car Capital LLC | Institution | 1.382.339 | 6,35% | US$ 8,40M | 2026-03-31 |
| Funicular Fund, LP | Institution | 1.114.747 | 5,12% | US$ 6,78M | 2026-02-11 |
| Ikarian Capital, LLC | Institution | 1.056.259 | 4,85% | US$ 6,42M | 2026-03-31 |
| Manchester Management Company, LLC | Institution | 919.935 | 4,22% | US$ 5,59M | 2026-03-31 |
| Mr. Morgan Frank | Insider | 888.935 | 4,08% | US$ 5,40M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 567.616 | 2,61% | US$ 3,45M | 2026-03-31 |
| Special Situations Fund III QP, L.P. | Institution | 544.032 | 2,50% | US$ 3,31M | 2024-12-31 |
| Alyeska Investment Group, L.P. | Institution | 365.000 | 1,68% | US$ 2,22M | 2026-03-31 |
| Special Situations Life Sciences Fund, L.P | Institution | 347.826 | 1,60% | US$ 2,11M | 2024-12-31 |
| Mr. John Havens | Insider | 285.587 | 1,31% | US$ 1,74M | 2025-04-22 |
| Mr. Len Mertz | Insider | 259.998 | 1,19% | US$ 1,58M | 2026-01-14 |
| Boothbay Fund Management, LLC | Institution | 256.393 | 1,18% | US$ 1,56M | 2026-03-31 |
| Nutie Dowdle | Insider | 230.712 | 1,06% | US$ 1,40M | 2024-11-06 |
| Rotorua Partners L.P. | Institution | 221.277 | 1,02% | US$ 1,35M | 2024-11-06 |
| Aristides Capital LLC | Institution | 218.510 | 1,00% | US$ 1,33M | 2026-03-31 |
| Mr. Kenneth Cawkell | Insider | 218.476 | 1,00% | US$ 1,33M | 2026-01-14 |
| Cantor Fitzgerald Asset Management | Institution | 188.631 | 0,87% | US$ 1,15M | 2026-03-31 |
| Special Situations Cayman Fund, L.P. | Institution | 161.620 | 0,74% | US$ 982,65k | 2024-12-31 |
| Mr. James Besser | Insider | 157.000 | 0,72% | US$ 954,56k | 2026-03-31 |
| Ms. Lauren D’Angelo | Insider | 140.695 | 0,65% | US$ 855,43k | 2026-05-19 |
| Special Situations Private Equity Fund, L.P. | Institution | 109.091 | 0,50% | US$ 663,27k | 2024-12-31 |
| Citadel Advisors LLC | Institution | 89.589 | 0,41% | US$ 544,70k | 2026-03-31 |
| St. Denis J. Villere & Co., LLC | Institution | 71.158 | 0,33% | US$ 432,64k | 2026-03-31 |
| Tudor Investment Corporation | Institution | 61.596 | 0,28% | US$ 374,50k | 2026-03-31 |
| ACT Capital Management | Institution | 51.500 | 0,24% | US$ 313,12k | 2026-03-31 |
| Mr. Phillip Mertz | Insider | 22.462 | 0,10% | US$ 136,57k | 2026-01-14 |
| Berkshire Asset Management, LLC | Institution | 19.824 | 0,09% | US$ 120,53k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 15.886 | 0,07% | US$ 96,59k | 2026-03-31 |
| Dr. Robert Wills | Insider | 15.000 | 0,07% | US$ 91,20k | 2026-01-14 |
| Mr. Donald Kalkofen | Insider | 14.700 | 0,07% | US$ 89,38k | 2025-01-10 |
| Mr. Michael McFadden | Insider | 14.142 | 0,06% | US$ 85,98k | 2026-01-09 |
| Mertz Holdings | Institution | 12.560 | 0,06% | US$ 76,36k | 2026-01-14 |
| FMR LLC | Institution | 11.992 | 0,06% | US$ 72,91k | 2026-02-28 |
| Geode Capital Management, LLC | Institution | 11.992 | 0,06% | US$ 72,91k | 2026-03-31 |
| Mr. Rajeev Bakshi | Insider | 11.843 | 0,05% | US$ 72,01k | 2026-01-14 |
| Raymond James Financial, Inc. | Institution | 10.000 | 0,05% | US$ 60,80k | 2026-03-31 |
| National Bank Investments Inc. | Institution | 5.292 | 0,02% | US$ 32,18k | 2026-03-31 |
| Allworth Financial, L.P. | Institution | 750 | 0,00% | US$ 4,56k | 2026-03-31 |
| Royal Bank of Canada | Institution | 557 | 0,00% | US$ 3,39k | 2026-03-31 |
| UBS Asset Management AG | Institution | 438 | 0,00% | US$ 2,66k | 2026-03-31 |
| Steward Partners Investment Advisory, LLC | Institution | 200 | 0,00% | US$ 1,22k | 2026-03-31 |
| RBC Dominion Securities Inc. | Institution | 122 | 0,00% | US$ 741,76 | 2026-03-31 |
| Edward Jones Trust Company | Institution | 100 | 0,00% | US$ 608,00 | 2026-03-31 |
| Harbour Investments, Inc. | Institution | 4 | 0,00% | US$ 24,32 | 2026-03-31 |
| Green Alpha Advisors, LLC | Institution | 0 | 0,00% | - | 2026-03-31 |