| Opaleye Management Inc. | Institution | 2.742.574 | 12,60% | US$ 18,05M | 2026-06-15 |
| Opaleye L.P | Institution | 2.652.574 | 12,18% | US$ 17,45M | 2026-06-15 |
| Solas Capital Management, LLC | Institution | 1.924.617 | 8,84% | US$ 12,66M | 2026-03-31 |
| AWM Investment Company Inc | Institution | 1.672.168 | 7,68% | US$ 11,00M | 2026-03-31 |
| Cable Car Capital LLC | Institution | 1.382.339 | 6,35% | US$ 9,10M | 2026-03-31 |
| Funicular Fund, LP | Institution | 1.114.747 | 5,12% | US$ 7,34M | 2026-02-11 |
| Ikarian Capital, LLC | Institution | 1.056.259 | 4,85% | US$ 6,95M | 2026-03-31 |
| Manchester Management Company, LLC | Institution | 919.935 | 4,22% | US$ 6,05M | 2026-03-31 |
| Mr. Morgan Frank | Insider | 888.935 | 4,08% | US$ 5,85M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 567.616 | 2,61% | US$ 3,73M | 2026-03-31 |
| Special Situations Fund III QP, L.P. | Institution | 544.032 | 2,50% | US$ 3,58M | 2024-12-31 |
| Alyeska Investment Group, L.P. | Institution | 365.000 | 1,68% | US$ 2,40M | 2026-03-31 |
| Special Situations Life Sciences Fund, L.P | Institution | 347.826 | 1,60% | US$ 2,29M | 2024-12-31 |
| Mr. John Havens | Insider | 285.587 | 1,31% | US$ 1,88M | 2025-04-22 |
| Mr. Len Mertz | Insider | 259.998 | 1,19% | US$ 1,71M | 2026-01-14 |
| Boothbay Fund Management, LLC | Institution | 256.393 | 1,18% | US$ 1,69M | 2026-03-31 |
| Nutie Dowdle | Insider | 230.712 | 1,06% | US$ 1,52M | 2024-11-06 |
| Rotorua Partners L.P. | Institution | 221.277 | 1,02% | US$ 1,46M | 2024-11-06 |
| Aristides Capital LLC | Institution | 218.510 | 1,00% | US$ 1,44M | 2026-03-31 |
| Mr. Kenneth Cawkell | Insider | 218.476 | 1,00% | US$ 1,44M | 2026-01-14 |
| Cantor Fitzgerald Asset Management | Institution | 188.631 | 0,87% | US$ 1,24M | 2026-03-31 |
| Special Situations Cayman Fund, L.P. | Institution | 161.620 | 0,74% | US$ 1,06M | 2024-12-31 |
| Mr. James Besser | Insider | 157.000 | 0,72% | US$ 1,03M | 2026-03-31 |
| Ms. Lauren D’Angelo | Insider | 140.695 | 0,65% | US$ 925,77k | 2026-05-19 |
| Special Situations Private Equity Fund, L.P. | Institution | 109.091 | 0,50% | US$ 717,82k | 2024-12-31 |
| Citadel Advisors LLC | Institution | 89.589 | 0,41% | US$ 589,50k | 2026-03-31 |
| St. Denis J. Villere & Co., LLC | Institution | 71.158 | 0,33% | US$ 468,22k | 2026-03-31 |
| Tudor Investment Corporation | Institution | 61.596 | 0,28% | US$ 405,30k | 2026-03-31 |
| ACT Capital Management | Institution | 51.500 | 0,24% | US$ 338,87k | 2026-03-31 |
| Mr. Phillip Mertz | Insider | 22.462 | 0,10% | US$ 147,80k | 2026-01-14 |
| Berkshire Asset Management, LLC | Institution | 19.824 | 0,09% | US$ 130,44k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 15.886 | 0,07% | US$ 104,53k | 2026-03-31 |
| Dr. Robert Wills | Insider | 15.000 | 0,07% | US$ 98,70k | 2026-01-14 |
| Mr. Donald Kalkofen | Insider | 14.700 | 0,07% | US$ 96,73k | 2025-01-10 |
| Mr. Michael McFadden | Insider | 14.142 | 0,06% | US$ 93,05k | 2026-01-09 |
| Mertz Holdings | Institution | 12.560 | 0,06% | US$ 82,64k | 2026-01-14 |
| Geode Capital Management, LLC | Institution | 11.992 | 0,06% | US$ 78,91k | 2026-03-31 |
| FMR LLC | Institution | 11.991 | 0,06% | US$ 78,90k | 2026-03-31 |
| Mr. Rajeev Bakshi | Insider | 11.843 | 0,05% | US$ 77,93k | 2026-01-14 |
| Raymond James Financial, Inc. | Institution | 10.000 | 0,05% | US$ 65,80k | 2026-03-31 |
| National Bank Investments Inc. | Institution | 5.292 | 0,02% | US$ 34,82k | 2026-03-31 |
| Allworth Financial, L.P. | Institution | 750 | 0,00% | US$ 4,94k | 2026-03-31 |
| Royal Bank of Canada | Institution | 557 | 0,00% | US$ 3,67k | 2026-03-31 |
| UBS Asset Management AG | Institution | 438 | 0,00% | US$ 2,88k | 2026-03-31 |
| Steward Partners Investment Advisory, LLC | Institution | 200 | 0,00% | US$ 1,32k | 2026-03-31 |
| RBC Dominion Securities Inc. | Institution | 122 | 0,00% | US$ 802,76 | 2026-03-31 |
| Edward Jones Trust Company | Institution | 100 | 0,00% | US$ 658,00 | 2026-03-31 |
| Harbour Investments, Inc. | Institution | 4 | 0,00% | US$ 26,32 | 2026-03-31 |
| Green Alpha Advisors, LLC | Institution | 0 | 0,00% | - | 2026-03-31 |