| Baker Bros. Advisors LP | Institution | 42.896.690 | 25,05% | US$ 919,28M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 39.254.169 | 22,92% | US$ 841,22M | 2026-02-24 |
| BlackRock, Inc. | Institution | 21.550.921 | 12,59% | US$ 461,84M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 8.671.645 | 5,06% | US$ 185,83M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 8.332.771 | 4,87% | US$ 178,57M | 2026-03-31 |
| RTW Investments, LP | Institution | 7.144.524 | 4,17% | US$ 153,11M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 5.661.400 | 3,31% | US$ 121,32M | 2026-03-31 |
| 667, L.P. | Institution | 3.546.939 | 2,07% | US$ 76,01M | 2026-02-24 |
| Geode Capital Management, LLC | Institution | 3.464.689 | 2,02% | US$ 74,25M | 2026-03-31 |
| First Trust Advisors LP | Institution | 3.343.868 | 1,95% | US$ 71,66M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 3.155.160 | 1,84% | US$ 67,62M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 2.872.695 | 1,68% | US$ 61,56M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 2.577.916 | 1,51% | US$ 55,24M | 2026-03-31 |
| Braidwell LP | Institution | 2.471.199 | 1,44% | US$ 52,96M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 2.026.044 | 1,18% | US$ 43,42M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.724.196 | 1,01% | US$ 36,95M | 2026-03-31 |
| Arrowstreet Capital, Limited Partnership | Institution | 1.569.491 | 0,92% | US$ 33,63M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 1.507.527 | 0,88% | US$ 32,31M | 2025-12-31 |
| Frazier Life Sciences Management, LP | Institution | 1.438.198 | 0,84% | US$ 30,82M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 1.331.813 | 0,78% | US$ 28,54M | 2026-03-31 |
| Fred Alger Management, LLC | Institution | 1.277.151 | 0,75% | US$ 27,37M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.272.611 | 0,74% | US$ 27,27M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.173.586 | 0,69% | US$ 25,15M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.163.943 | 0,68% | US$ 24,94M | 2026-03-31 |
| Rockefeller & Co. LLC | Institution | 1.027.357 | 0,60% | US$ 22,02M | 2026-03-31 |
| Massachusetts Financial Services Company | Institution | 1.019.824 | 0,60% | US$ 21,85M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 986.476 | 0,58% | US$ 21,14M | 2026-03-31 |
| Allspring Global Investments, LLC | Institution | 954.855 | 0,56% | US$ 20,46M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 950.299 | 0,55% | US$ 20,36M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 875.720 | 0,51% | US$ 18,77M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 840.414 | 0,49% | US$ 18,01M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 803.265 | 0,47% | US$ 17,21M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 775.121 | 0,45% | US$ 16,61M | 2026-03-31 |
| Principal Global Investors, LLC | Institution | 768.224 | 0,45% | US$ 16,46M | 2026-03-31 |
| Bank of America Corporation | Institution | 754.096 | 0,44% | US$ 16,16M | 2026-03-31 |
| Morgan Stanley | Institution | 753.679 | 0,44% | US$ 16,15M | 2026-03-31 |