| Baker Bros. Advisors LP | Institution | 43.024.700 | 25,13% | US$ 1,02B | 2026-05-29 |
| Baker Brothers Life Sciences, L.P. | Institution | 39.365.965 | 22,99% | US$ 933,76M | 2026-05-29 |
| BlackRock, Inc. | Institution | 21.550.921 | 12,59% | US$ 511,19M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 8.671.645 | 5,06% | US$ 205,69M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 8.332.771 | 4,87% | US$ 197,65M | 2026-03-31 |
| RTW Investments, LP | Institution | 7.144.524 | 4,17% | US$ 169,47M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 5.661.400 | 3,31% | US$ 134,29M | 2026-03-31 |
| 667, L.P. | Institution | 3.658.735 | 2,14% | US$ 86,79M | 2026-05-29 |
| Geode Capital Management, LLC | Institution | 3.464.689 | 2,02% | US$ 82,18M | 2026-03-31 |
| First Trust Advisors LP | Institution | 3.343.868 | 1,95% | US$ 79,32M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 3.155.160 | 1,84% | US$ 74,84M | 2026-03-31 |
| Palo Alto Investors LP | Institution | 2.872.695 | 1,68% | US$ 68,14M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 2.577.916 | 1,51% | US$ 61,15M | 2026-03-31 |
| Braidwell LP | Institution | 2.471.199 | 1,44% | US$ 58,62M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 2.026.044 | 1,18% | US$ 48,06M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.724.196 | 1,01% | US$ 40,90M | 2026-03-31 |
| Arrowstreet Capital, Limited Partnership | Institution | 1.569.491 | 0,92% | US$ 37,23M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 1.507.527 | 0,88% | US$ 35,76M | 2025-12-31 |
| Frazier Life Sciences Management, LP | Institution | 1.438.198 | 0,84% | US$ 34,11M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 1.331.813 | 0,78% | US$ 31,59M | 2026-03-31 |
| Fred Alger Management, LLC | Institution | 1.277.151 | 0,75% | US$ 30,29M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.272.611 | 0,74% | US$ 30,19M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.173.586 | 0,69% | US$ 27,84M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.163.943 | 0,68% | US$ 27,61M | 2026-03-31 |
| Rockefeller & Co. LLC | Institution | 1.027.357 | 0,60% | US$ 24,37M | 2026-03-31 |
| Massachusetts Financial Services Company | Institution | 1.019.824 | 0,60% | US$ 24,19M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 986.476 | 0,58% | US$ 23,40M | 2026-03-31 |
| Allspring Global Investments, LLC | Institution | 954.855 | 0,56% | US$ 22,65M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 950.299 | 0,55% | US$ 22,54M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 875.720 | 0,51% | US$ 20,77M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 840.414 | 0,49% | US$ 19,93M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 803.265 | 0,47% | US$ 19,05M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 775.121 | 0,45% | US$ 18,39M | 2026-03-31 |
| Principal Global Investors, LLC | Institution | 768.224 | 0,45% | US$ 18,22M | 2026-03-31 |
| Bank of America Corporation | Institution | 754.096 | 0,44% | US$ 17,89M | 2026-03-31 |