| RA Capital Management, L.P. | Institution | 20.992.669 | 29,06% | US$ 46,39M | 2026-06-03 |
| RA Capital Healthcare Fund, L.P. | Institution | 19.103.785 | 26,45% | US$ 42,22M | 2026-06-03 |
| Sands Capital Alternatives, LLC | Institution | 3.720.105 | 5,15% | US$ 8,22M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 2.454.754 | 3,40% | US$ 5,43M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.305.096 | 3,19% | US$ 5,09M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.156.334 | 2,99% | US$ 4,77M | 2026-03-31 |
| Knollwood Investment Advisory, LLC | Institution | 1.628.510 | 2,25% | US$ 3,60M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.506.277 | 2,09% | US$ 3,33M | 2026-03-31 |
| RA Capital Nexus Fund II, L.P. | Institution | 1.300.034 | 1,80% | US$ 2,87M | 2026-06-03 |
| FMR LLC | Institution | 1.157.346 | 1,60% | US$ 2,56M | 2026-03-31 |
| Sands Capital Management, LLC | Institution | 1.146.173 | 1,59% | US$ 2,53M | 2025-06-30 |
| Sands Capital Life Sciences Pulse Fund I, L.P. | Institution | 1.146.173 | 1,59% | US$ 2,53M | 2025-06-30 |
| Sands Capital Global Ventures Fund II, L.P. | Institution | 1.146.173 | 1,59% | US$ 2,53M | 2025-06-30 |
| Ikarian Capital, LLC | Institution | 1.053.797 | 1,46% | US$ 2,33M | 2026-03-31 |
| Hudson Bay Capital Management LP | Institution | 968.940 | 1,34% | US$ 2,14M | 2026-03-31 |
| Pathstone Family Office, LLC | Institution | 859.110 | 1,19% | US$ 1,90M | 2026-03-31 |
| SG Americas Securities, LLC | Institution | 719.257 | 1,00% | US$ 1,59M | 2026-03-31 |
| Millennium Management LLC | Institution | 659.675 | 0,91% | US$ 1,46M | 2026-03-31 |
| Tiger Lily Capital | Institution | 657.985 | 0,91% | US$ 1,45M | 2025-04-08 |
| Susquehanna International Group, LLP | Institution | 601.476 | 0,83% | US$ 1,33M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 530.812 | 0,73% | US$ 1,17M | 2026-03-31 |
| Laurion Capital Management LP | Institution | 525.444 | 0,73% | US$ 1,16M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 473.946 | 0,66% | US$ 1,05M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 416.238 | 0,58% | US$ 919,89k | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 273.012 | 0,38% | US$ 603,36k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 199.226 | 0,28% | US$ 440,29k | 2026-03-31 |
| Marshall Wace LLP | Institution | 192.889 | 0,27% | US$ 426,28k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 185.850 | 0,26% | US$ 410,73k | 2026-03-31 |
| BlackRock, Inc. | Institution | 178.326 | 0,25% | US$ 394,10k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 176.171 | 0,24% | US$ 389,34k | 2026-03-31 |
| Bank of America Corporation | Institution | 161.516 | 0,22% | US$ 356,95k | 2026-03-31 |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | Institution | 158.700 | 0,22% | US$ 350,73k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 156.853 | 0,22% | US$ 346,65k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 151.728 | 0,21% | US$ 335,32k | 2026-03-31 |
| BBVA Asset Management, S.A., S.G.I.I.C | Institution | 149.837 | 0,21% | US$ 331,14k | 2025-06-30 |
| Morgan Stanley | Institution | 144.584 | 0,20% | US$ 319,53k | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 120.388 | 0,17% | US$ 266,06k | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 119.756 | 0,17% | US$ 264,66k | 2026-03-31 |