| RA Capital Management, L.P. | Institution | 20.992.669 | 29,06% | US$ 48,07M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 19.103.785 | 26,45% | US$ 43,75M | 2026-03-16 |
| Sands Capital Alternatives, LLC | Institution | 3.720.105 | 5,15% | US$ 8,52M | 2026-03-31 |
| Dr. James Murray | Insider | 3.611.360 | 5,00% | US$ 8,27M | 2026-04-06 |
| Mr. Robert Hardie | Insider | 3.451.152 | 4,78% | US$ 7,90M | 2025-04-08 |
| Mr. Paul Manning | Insider | 2.547.143 | 3,53% | US$ 5,83M | 2025-04-08 |
| Alyeska Investment Group, L.P. | Institution | 2.454.754 | 3,40% | US$ 5,62M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 2.305.096 | 3,19% | US$ 5,28M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.156.334 | 2,99% | US$ 4,94M | 2026-03-31 |
| Knollwood Investment Advisory, LLC | Institution | 1.628.510 | 2,25% | US$ 3,73M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.506.277 | 2,09% | US$ 3,45M | 2026-03-31 |
| RA Capital Nexus Fund II, L.P. | Institution | 1.300.034 | 1,80% | US$ 2,98M | 2026-03-16 |
| FMR LLC | Institution | 1.157.346 | 1,60% | US$ 2,65M | 2026-03-31 |
| Sands Capital Life Sciences Pulse Fund I, L.P. | Institution | 1.146.173 | 1,59% | US$ 2,62M | 2025-06-30 |
| Sands Capital Global Ventures Fund II, L.P. | Institution | 1.146.173 | 1,59% | US$ 2,62M | 2025-06-30 |
| Sands Capital Management, LLC | Institution | 1.146.173 | 1,59% | US$ 2,62M | 2025-06-30 |
| Ikarian Capital, LLC | Institution | 1.053.797 | 1,46% | US$ 2,41M | 2026-03-31 |
| Hudson Bay Capital Management LP | Institution | 968.940 | 1,34% | US$ 2,22M | 2026-03-31 |
| Pathstone Family Office, LLC | Institution | 859.110 | 1,19% | US$ 1,97M | 2026-03-31 |
| SG Americas Securities, LLC | Institution | 719.257 | 1,00% | US$ 1,65M | 2026-03-31 |
| Millennium Management LLC | Institution | 659.675 | 0,91% | US$ 1,51M | 2026-03-31 |
| Tiger Lily Capital | Institution | 657.985 | 0,91% | US$ 1,51M | 2025-04-08 |
| Susquehanna International Group, LLP | Institution | 601.476 | 0,83% | US$ 1,38M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 530.812 | 0,73% | US$ 1,22M | 2026-03-31 |
| Laurion Capital Management LP | Institution | 525.444 | 0,73% | US$ 1,20M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 473.946 | 0,66% | US$ 1,09M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 416.238 | 0,58% | US$ 953,19k | 2026-03-31 |
| Mr. Sean Stalfort | Insider | 303.919 | 0,42% | US$ 695,97k | 2026-04-08 |
| Mr. Daniel O'Connell | Insider | 297.543 | 0,41% | US$ 681,37k | 2026-04-08 |
| Boothbay Fund Management, LLC | Institution | 273.012 | 0,38% | US$ 625,20k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 199.226 | 0,28% | US$ 456,23k | 2026-03-31 |
| Marshall Wace LLP | Institution | 192.889 | 0,27% | US$ 441,72k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 185.850 | 0,26% | US$ 425,60k | 2026-03-31 |
| BlackRock, Inc. | Institution | 178.326 | 0,25% | US$ 408,37k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 176.171 | 0,24% | US$ 403,43k | 2026-03-31 |
| Bank of America Corporation | Institution | 161.516 | 0,22% | US$ 369,87k | 2026-03-31 |
| Merrill Lynch, Pierce, Fenner & Smith Incorporated | Institution | 158.700 | 0,22% | US$ 363,42k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 156.853 | 0,22% | US$ 359,19k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 151.728 | 0,21% | US$ 347,46k | 2026-03-31 |
| BBVA Asset Management, S.A., S.G.I.I.C | Institution | 149.837 | 0,21% | US$ 343,13k | 2025-06-30 |
| Morgan Stanley | Institution | 144.584 | 0,20% | US$ 331,10k | 2026-03-31 |