| Dr. Carl Hansen | Insider | 57.032.097 | 18,68% | US$ 349,61M | 2026-04-01 |
| Baker Bros. Advisors LP | Institution | 30.275.938 | 9,92% | US$ 185,59M | 2026-04-30 |
| Baker Brothers Life Sciences, L.P. | Institution | 28.021.365 | 9,18% | US$ 171,77M | 2026-04-30 |
| Capital Research and Management Company | Institution | 13.361.096 | 4,38% | US$ 81,90M | 2026-03-31 |
| UBS Asset Management AG | Institution | 11.784.528 | 3,86% | US$ 72,24M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 10.562.065 | 3,46% | US$ 64,75M | 2026-03-31 |
| Dr. Veronique Lecault | Insider | 9.613.674 | 3,15% | US$ 58,93M | 2026-04-01 |
| ArrowMark Colorado Holdings, LLC | Institution | 4.105.095 | 1,34% | US$ 25,16M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.040.236 | 1,32% | US$ 24,77M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 4.024.779 | 1,32% | US$ 24,67M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 3.751.212 | 1,23% | US$ 22,99M | 2026-03-31 |
| Bank of America Corporation | Institution | 2.999.936 | 0,98% | US$ 18,39M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 2.746.200 | 0,90% | US$ 16,83M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 2.592.105 | 0,85% | US$ 15,89M | 2026-03-31 |
| Tudor Investment Corporation | Institution | 2.273.489 | 0,74% | US$ 13,94M | 2026-03-31 |
| 667, L.P. | Institution | 2.254.573 | 0,74% | US$ 13,82M | 2026-04-30 |
| Morgan Stanley | Institution | 2.217.529 | 0,73% | US$ 13,59M | 2026-03-31 |
| Guardian Partners Inc. | Institution | 1.786.415 | 0,59% | US$ 10,95M | 2026-03-31 |
| LGPS Central Limited | Institution | 1.644.996 | 0,54% | US$ 10,08M | 2025-03-31 |
| LGPS Central Global Sustainable Equity Active Targeted Fund | Institution | 1.644.996 | 0,54% | US$ 10,08M | 2025-03-31 |
| Renaissance Technologies LLC | Institution | 1.510.629 | 0,49% | US$ 9,26M | 2026-03-31 |
| Dr. Michael Hayden | Insider | 1.441.642 | 0,47% | US$ 8,84M | 2026-04-01 |
| Citadel Advisors LLC | Institution | 1.361.105 | 0,45% | US$ 8,34M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.294.574 | 0,42% | US$ 7,94M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 1.235.153 | 0,40% | US$ 7,57M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.149.325 | 0,38% | US$ 7,05M | 2026-03-31 |
| Dr. Stephen Quake | Insider | 1.100.436 | 0,36% | US$ 6,75M | 2026-04-01 |
| Acatis Anlageberatung fur Investmentfonds GmbH | Institution | 1.000.000 | 0,33% | US$ 6,13M | 2025-04-30 |
| Jane Street Group, LLC | Institution | 847.883 | 0,28% | US$ 5,20M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 750.393 | 0,25% | US$ 4,60M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 730.213 | 0,24% | US$ 4,48M | 2026-03-31 |
| Voloridge Investment Management, LLC | Institution | 610.423 | 0,20% | US$ 3,74M | 2026-03-31 |
| Intellectus Partners, LLC | Institution | 546.083 | 0,18% | US$ 3,35M | 2026-03-31 |
| The State of Michigan Retirement Systems | Institution | 400.000 | 0,13% | US$ 2,45M | 2026-03-31 |
| Marshall Wace LLP | Institution | 359.683 | 0,12% | US$ 2,20M | 2026-03-31 |
| Osaic Wealth, Inc. | Institution | 348.978 | 0,11% | US$ 2,14M | 2026-03-31 |
| SoftBank Group Corp. | Institution | 345.161 | 0,11% | US$ 2,12M | 2026-03-31 |
| SEB Funds AB | Institution | 340.267 | 0,11% | US$ 2,09M | 2026-03-31 |
| RBC Private Counsel (USA) Inc. | Institution | 329.738 | 0,11% | US$ 2,02M | 2026-03-31 |
| Mr. Andrew Booth | Insider | 326.559 | 0,11% | US$ 2,00M | 2026-04-01 |
| Geode Capital Management, LLC | Institution | 309.391 | 0,10% | US$ 1,90M | 2026-03-31 |