| Baker Bros. Advisors LP | Institution | 30.275.938 | 9,91% | US$ 182,56M | 2026-04-30 |
| Baker Brothers Life Sciences, L.P. | Institution | 28.021.365 | 9,18% | US$ 168,97M | 2026-04-30 |
| UBS Asset Management AG | Institution | 11.784.528 | 3,86% | US$ 71,06M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 10.562.065 | 3,46% | US$ 63,69M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 4.105.095 | 1,34% | US$ 24,75M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 4.024.779 | 1,32% | US$ 24,27M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 2.746.200 | 0,90% | US$ 16,56M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 2.592.105 | 0,85% | US$ 15,63M | 2026-03-31 |
| Tudor Investment Corporation | Institution | 2.273.489 | 0,74% | US$ 13,71M | 2026-03-31 |
| 667, L.P. | Institution | 2.254.573 | 0,74% | US$ 13,60M | 2026-04-30 |
| Guardian Partners Inc. | Institution | 1.786.415 | 0,58% | US$ 10,77M | 2026-03-31 |
| LGPS Central Limited | Institution | 1.644.996 | 0,54% | US$ 9,92M | 2025-03-31 |
| LGPS Central Global Sustainable Equity Active Targeted Fund | Institution | 1.644.996 | 0,54% | US$ 9,92M | 2025-03-31 |
| Renaissance Technologies LLC | Institution | 1.510.629 | 0,49% | US$ 9,11M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.361.105 | 0,45% | US$ 8,21M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.294.574 | 0,42% | US$ 7,81M | 2026-03-31 |
| Hudson River Trading LLC | Institution | 1.235.153 | 0,40% | US$ 7,45M | 2026-03-31 |
| Acatis Anlageberatung fur Investmentfonds GmbH | Institution | 1.000.000 | 0,33% | US$ 6,03M | 2025-04-30 |
| Jane Street Group, LLC | Institution | 847.883 | 0,28% | US$ 5,11M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 750.393 | 0,25% | US$ 4,52M | 2026-03-31 |
| Voloridge Investment Management, LLC | Institution | 610.423 | 0,20% | US$ 3,68M | 2026-03-31 |
| Intellectus Partners, LLC | Institution | 546.083 | 0,18% | US$ 3,29M | 2026-03-31 |
| Osaic Wealth, Inc. | Institution | 348.978 | 0,11% | US$ 2,10M | 2026-03-31 |
| SoftBank Group Corp. | Institution | 345.161 | 0,11% | US$ 2,08M | 2026-03-31 |
| Clarfeld Financial Advisors, LLC | Institution | 261.890 | 0,09% | US$ 1,58M | 2026-03-31 |
| Group One Trading LLC | Institution | 239.133 | 0,08% | US$ 1,44M | 2026-03-31 |
| Simplex Trading, LLC | Institution | 201.236 | 0,07% | US$ 1,21M | 2026-03-31 |
| Headlands Tech Holdings, LLC | Institution | 182.656 | 0,06% | US$ 1,10M | 2026-03-31 |
| Engineers Gate Manager LP | Institution | 181.472 | 0,06% | US$ 1,09M | 2026-03-31 |
| AXQ Capital, LP | Institution | 136.227 | 0,04% | US$ 821,45k | 2026-03-31 |
| Voleon Capital Management LP | Institution | 122.547 | 0,04% | US$ 738,96k | 2026-03-31 |
| Pier 88 Investment Partners, LLC | Institution | 120.100 | 0,04% | US$ 724,20k | 2026-03-31 |