| Invesco Ltd. | Institution | 41.011.890 | 16,85% | £ 53,32M | 2026-05-01 |
| Citigroup Inc. | Institution | 14.491.273 | 5,95% | £ 18,84M | 2026-05-28 |
| Lansdowne Partners Limited | Institution | 13.899.145 | 5,71% | £ 18,07M | 2026-05-01 |
| Briarwood Chase Management LLC | Institution | 12.398.267 | 5,09% | £ 16,12M | 2026-05-06 |
| Tang Capital Management, LLC | Institution | 12.215.934 | 5,02% | £ 15,88M | 2026-05-01 |
| Recordati Industria Chimica e Farmaceutica S.p.A. | Institution | 9.554.140 | 3,92% | £ 12,42M | 2026-05-01 |
| Baillie Gifford & Co. | Institution | 7.287.721 | 2,99% | £ 9,47M | 2026-05-01 |
| Tang Capital Partners, LP | Institution | 7.094.228 | 2,91% | £ 9,22M | 2026-04-22 |
| UBS Asset Management AG | Institution | 5.883.012 | 2,42% | £ 7,65M | 2026-05-01 |
| Aberdeen Group Plc | Institution | 5.198.939 | 2,14% | £ 6,76M | 2026-05-01 |
| Hargreaves Lansdown Asset Management Ltd. | Institution | 5.136.784 | 2,11% | £ 6,68M | 2026-05-01 |
| Jupiter Fund Management Plc | Institution | 4.945.325 | 2,03% | £ 6,43M | 2026-05-01 |
| Tang Capital Partners International, LP | Institution | 4.882.675 | 2,01% | £ 6,35M | 2026-04-22 |
| Vitruvian Partners LLP | Institution | 4.839.654 | 1,99% | £ 6,29M | 2026-05-01 |
| Fidelity International Ltd | Institution | 4.247.296 | 1,74% | £ 5,52M | 2026-05-01 |
| J O Hambro Capital Management Limited | Institution | 3.950.000 | 1,62% | £ 5,14M | 2026-05-01 |
| Stifel Asset Management Corp. | Institution | 3.827.775 | 1,57% | £ 4,98M | 2026-05-01 |
| Ms. Daphne Zohar | Insider | 3.560.971 | 1,46% | £ 4,63M | 2026-05-01 |
| Norges Bank Investment Management | Institution | 3.415.776 | 1,40% | £ 4,44M | 2026-05-01 |
| Interactive Brokers Group, Inc. | Institution | 3.362.558 | 1,38% | £ 4,37M | 2026-05-01 |
| JPMorgan Chase & Co. | Institution | 3.362.082 | 1,38% | £ 4,37M | 2026-05-01 |
| Dr. Robert S. Langer | Insider | 3.281.003 | 1,35% | £ 4,27M | 2026-05-01 |
| M&G Investment Management Limited | Institution | 3.122.942 | 1,28% | £ 4,06M | 2026-05-01 |
| Charles Schwab Investment Management, Inc. | Institution | 3.069.679 | 1,26% | £ 3,99M | 2026-05-01 |
| ADAR1 Capital Management, LLC | Institution | 3.000.000 | 1,23% | £ 3,90M | 2026-05-01 |
| Barclays Bank PLC | Institution | 2.958.263 | 1,22% | £ 3,85M | 2026-05-01 |
| FMR LLC | Institution | 2.607.237 | 1,07% | £ 3,39M | 2026-05-01 |
| London Wealth Management Limited | Institution | 2.601.790 | 1,07% | £ 3,38M | 2026-05-01 |
| Canaccord Genuity Asset Management Limited | Institution | 2.550.000 | 1,05% | £ 3,32M | 2026-05-01 |
| TD Asset Management, Inc. | Institution | 2.401.063 | 0,99% | £ 3,12M | 2026-05-01 |
| BNY Mellon Advisors, Inc. | Institution | 2.005.000 | 0,82% | £ 2,61M | 2026-05-01 |
| BlackRock, Inc. | Institution | 1.984.759 | 0,82% | £ 2,58M | 2026-05-01 |
| Legal & General Investment Management Limited | Institution | 1.683.235 | 0,69% | £ 2,19M | 2026-05-01 |
| Irenic Capital Management LP | Institution | 1.555.856 | 0,64% | £ 2,02M | 2026-05-01 |
| Dr. John LaMattina | Insider | 1.518.100 | 0,62% | £ 1,97M | 2026-05-01 |
| Vanguard Asset Management, Limited | Institution | 1.277.404 | 0,52% | £ 1,66M | 2026-05-01 |
| Mole Valley Asset Management Ltd | Institution | 1.271.694 | 0,52% | £ 1,65M | 2026-05-01 |
| Gem Investment Advisors, LLC | Institution | 1.254.099 | 0,52% | £ 1,63M | 2026-05-01 |
| Gem Partners L.P. | Institution | 1.254.099 | 0,52% | £ 1,63M | 2026-05-01 |