N4 Pharma PLC Research collaboration update (3130G)
05 November 2018 - 8:54AM
UK Regulatory
TIDMN4P
RNS Number : 3130G
N4 Pharma PLC
05 November 2018
05 November 2018
N4 Pharma Plc
("N4 Pharma" or the "Company")
Research collaboration update
N4 Pharma Plc (AIM: N4P), the specialist pharmaceutical company
developing a novel delivery system for vaccines and cancer
treatments, today provides an update on its collaboration with
MedImmune, following the conclusion of the Innovate UK feasibility
grant announced on 2 February 2018.
The grant was provided by Innovate UK to co-fund a collaborative
project with MedImmune to explore the manufacture of a prototype
nanomedicine using N4 Pharma's Nuvec(R) system. The initial term of
the project with MedImmune was a period of nine months ending 31
October 2018. In total, the Company will receive GBP63,000 from
Innovate UK.
The Company is pleased to announce that MedImmune has confirmed
its committment to investigating non-lipid nanoparticle
technologies for mRNA and pDNA delivery and its intention to
continue to work with N4 Pharma to conduct further ongoing research
with a view to agreeing terms for co-development of an optimised
version of Nuvec(R) under an appropriate collaboration
agreement.
Nigel Theobald, CEO of N4 Pharma commented:
"The grant has allowed us to take a positive step forward with
our Nuvec(R) delivery system and we are very grateful for the
support provided by Innovate UK and MedImmune.
"We are delighted that MedImmune is continuing to work with N4
Pharma to evaluate the potential of our Nuvec(R) system. MedImmune
is able to provide considerable expertise and resources for this
work and their continued support for N4 Pharma and Nuvec(R) is a
clear indication of Nuvec(R)'s potential as a non-lipid, non-viral
vaccine delivery technology and an example of how we can establish
separate agreements for different versions of the Nuvec(R) platform
technology."
About the Innovate grant
The grant was provided from Innovate UK's Medicines
Manufacturing Round 1: Challenge Fund, which itself is funded
through the UK Government's GBP70m Industrial Strategy Challenge
Fund to speed up the development of new medicines. It was provided
to enable N4 Pharma to develop manufacturing methods for Nuvec(R)
particles loaded with therapeutic pDNA/mRNA encoding antigens and
to demonstrate that such nanoparticles can be manufactured to the
quality required for in-vivo studies. MedImmune has been evaluating
these Nuvec(R) formulations in relevant in-vitro and in-vivo models
to demonstrate if they are able to deliver functional pDNA/mRNA
capable of inducing an immune response.
Enquiries:
N4 Pharma Plc
Nigel Theobald, CEO Via Alma PR
Allenby Capital Limited Tel: +44(0)203 328 5656
James Reeve/Virginia Bull/Asha
Chotai
Alma PR
Josh Royston Tel: +44(0)778 090 1979
Robyn Fisher Tel: +44(0)754 070 6191
About N4 Pharma
N4 Pharma is a specialist pharmaceutical company developing a
novel delivery system for vaccines and cancer treatments using its
unique silica nanoparticle delivery system called Nuvec(R)
Nuvec(R) has shown to be capable of loading and delivering mRNA
and pDNA into cells to the required level needed to generate an
immune response. Further work will be undertaken for the direct
loading and delivery of peptides and proteins using Nuvec(R).
N4 Pharma's business model is to partner with companies
developing novel antigens for vaccines and cancer treatments to use
Nuvec(R) as the delivery vehicle to get their antigen into cells to
express the protein needed for the required immune response. As
these products progress through pre clinical and clinical programs
N4 will receive up front and milestone payments and ultimately
royalty payments once products reach the market.
About MedImmune UK
MedImmune is part of Astra Zeneca, having been acquired in 2007
for $15.6bn. It is a leading global biologics R&D company with
one of the largest, most robust pipelines in the industry,
including more than 120 research projects and product candidates,
that comprise nearly half of AstraZeneca's overall R&D
portfolio. It is focused on three core therapeutic areas: Oncology;
Respiratory, Inflammation and Autoimmune; and Cardiovascular and
Metabolic Disease. For further information visit:
https://www.medimmune.com/
About Innovate UK
Innovate UK is the UK's innovation agency. It works with people,
companies and partner organisations to find and drive the science
and technology innovations that will grow the UK economy. For
further information visit:
www.innovateuk.gov.uk
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END
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