GENI Genincode Plc

9 September 2024

GENinCode Plc

("GENinCode" or the "Company")

Notice of results

Analyst and investor briefing

Oxford, UK. GENinCode Plc (AIM: GENI), the predictive genetics company focused on the prevention of cardiovascular disease and ovarian cancer, announces that it will release its unaudited interim results for the six months ended 30 June 2024 on Wednesday, 25 September 2024.

Analyst briefing

A briefing open to equity research analysts will take place on Wednesday, 25 September 2024 at 09.30am BST. To register and for more details please contact Walbrook PR on genincode@walbrookpr.com.

Investor presentation

Matthew Walls, Chief Executive Officer, and Paul Foulger, Chief Financial Officer, will provide a live presentation relating to the results via the Investor Meet Company platform on Wednesday, 25 September at 4pm BST.

The presentation is open to all existing and potential shareholders. Questions can be submitted pre-event via the Investor Meet Company dashboard until 9am the day before the meeting or at any time during the live presentation.

Investors can sign up to Investor Meet Company for free and add to meet GENinCode here. Investors who already follow GENinCode on the Investor Meet Company platform will automatically be invited.

For more information visit www.genincode.com

Enquiries:

About GENinCode:

GENinCode Plc is a UK based company specialising in genetic risk assessment of cardiovascular disease and ovarian cancer. Cardiovascular disease is the leading cause of death and disability worldwide.

GENinCode operates business units in the UK, Europe through GENinCode S.L.U, and in the United States through GENinCode U.S. Inc.

GENinCode predictive technology provides patients and physicians with globally leading preventive care and treatment strategies. GENinCode invitro-diagnostic molecular tests combine clinical algorithms and AI bioinformatics to advance patient risk assessment to prevent the onset of cardiovascular disease and ovarian cancer.

About Cardiovascular Disease (CVD):

CVD is the leading cause of death globally, taking an estimated 17.9 million lives each year. CVD is a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease, rheumatic heart disease and other conditions. More than four out of five CVD deaths are due to heart attacks and strokes, and one third of these deaths occur prematurely in people under 70 years of age.

CVD causes a quarter of all deaths in the UK and is the largest cause of premature mortality in deprived areas with the NHS 10 Year Plan identifying CVD as the single biggest area where the NHS can save lives over the next 10 years. CVD is largely preventable, through lifestyle changes and a combination of public health and NHS action on smoking and tobacco addiction, obesity, tackling alcohol misuse and food reformulation.

Early detection and treatment of CVD can help patients live longer, healthier lives. Too many people are still living with undetected, high-risk conditions such as high blood pressure, raised cholesterol, and atrial fibrillation (AF). The NHS 10 Year Plan is working towards people knowing and managing risks around their 'ABC' (AF, Blood pressure and Cholesterol).

About Ovarian Cancer (OC) and the ROCA test:

OC occurs when abnormal cells in the ovaries or fallopian tubes grow and multiply out of control. Ovaries are part of the female reproductive system and are responsible for making eggs during a female's reproductive years.

OC affects women and people assigned female at birth. It accounts for 1% of all new cancer cases and the lifetime risk of developing OC is approximately 1 in 78. OC is slightly more common in white populations than in people who are Black, Hispanic or Asian, while people who inherit a BRCA gene mutation are consider high risk of developing the disease. BRCA gene mutations occur in 0.3% of the population but is more common in individuals of Ashkenazi Jewish or Greenlander descent. Preventative surgery (removal of both ovaries and fallopian tubes) is recommended for BRCA carriers.

Diagnosis of OC typically occurs late stage due to the presentation of vague symptoms that are often confused with other more common conditions. As a result, treatment is intense and long-term survival is poor. Despite years of research, experts have struggled to develop an effective OC surveillance test that can detect the disease earlier.

The Risk of Ovarian Cancer Algorithm (ROCA) Test is a globally leading OC surveillance test, proven to detect OC cancer before symptoms present and at an earlier stage. The test is intended for women over 35 with a mutation in the BRCA1 or BRCA2 gene and who wish to defer preventative surgery. The ROCA test has recently received National Institute for Care and Health Excellence (NICE) guideline recommendation for OC surveillance.