| Adage Capital Management, L.P. | Institution | 27.178.192 | 9,18% | 82,51M € | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 26.316.237 | 8,89% | 79,90M € | 2026-05-19 |
| MPM BioImpact LLC | Institution | 26.066.805 | 8,81% | 79,14M € | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 23.468.163 | 7,93% | 71,25M € | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 23.425.713 | 7,92% | 71,12M € | 2026-04-15 |
| Averill Master Fund, Ltd. | Institution | 23.425.713 | 7,92% | 71,12M € | 2026-04-15 |
| Artisan Partners Limited Partnership | Institution | 22.825.885 | 7,71% | 69,30M € | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 21.996.097 | 7,43% | 66,78M € | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 21.282.929 | 7,19% | 64,61M € | 2026-01-12 |
| Artal Group S.A. | Institution | 19.310.005 | 6,53% | 58,63M € | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 17.997.870 | 6,08% | 54,64M € | 2026-03-31 |
| Janus Henderson Group plc | Institution | 15.459.843 | 5,22% | 46,94M € | 2026-01-29 |
| Vivo Capital, LLC | Institution | 13.337.845 | 4,51% | 40,49M € | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 11.820.005 | 3,99% | 35,89M € | 2026-03-31 |
| Bpifrance Participations SA | Institution | 10.898.595 | 3,68% | 33,09M € | 2026-01-07 |
| The Goldman Sachs Group, Inc. | Institution | 7.165.123 | 2,42% | 21,75M € | 2025-11-10 |
| ADAR1 Capital Management, LLC | Institution | 5.064.330 | 1,71% | 15,38M € | 2026-03-31 |
| Syquant Capital SAS | Institution | 4.833.228 | 1,63% | 14,67M € | 2025-04-02 |
| Perceptive Advisors LLC | Institution | 4.821.955 | 1,63% | 14,64M € | 2026-03-31 |
| Yiheng Capital Management, L.P. | Institution | 4.132.210 | 1,40% | 12,55M € | 2026-03-31 |
| Braidwell LP | Institution | 3.899.300 | 1,32% | 11,84M € | 2024-12-31 |
| Patient Square Capital, LP | Institution | 3.467.670 | 1,17% | 10,53M € | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 2.871.000 | 0,97% | 8,72M € | 2026-03-31 |
| Redmile Group, LLC | Institution | 2.456.700 | 0,83% | 7,46M € | 2026-03-31 |
| Braidwell Partners Master Fund LP | Institution | 2.393.815 | 0,81% | 7,27M € | 2024-12-31 |
| 667, L.P. | Institution | 2.185.234 | 0,74% | 6,63M € | 2026-01-12 |
| Duquesne Family Office LLC | Institution | 1.916.815 | 0,65% | 5,82M € | 2026-03-31 |
| Averill Madison Master Fund, Ltd. | Institution | 1.783.701 | 0,60% | 5,42M € | 2025-10-13 |
| Millennium Management LLC | Institution | 1.594.795 | 0,54% | 4,84M € | 2026-03-31 |
| Vivo Opportunity Cayman Fund,L.P. | Institution | 1.517.840 | 0,51% | 4,61M € | 2026-03-31 |
| Atika Capital Management, LLC | Institution | 1.356.500 | 0,46% | 4,12M € | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 1.325.000 | 0,45% | 4,02M € | 2026-03-31 |
| Avicenna Life Sci Master Fund Lp | Institution | 1.312.135 | 0,44% | 3,98M € | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.167.145 | 0,39% | 3,54M € | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1.157.085 | 0,39% | 3,51M € | 2026-03-31 |
| New York State Common Retirement Fund | Institution | 840.900 | 0,28% | 2,55M € | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 817.005 | 0,28% | 2,48M € | 2026-03-31 |
| Morgan Stanley | Institution | 730.580 | 0,25% | 2,22M € | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 642.800 | 0,22% | 1,95M € | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 525.000 | 0,18% | 1,59M € | 2026-03-31 |
| Dorsey, Wright & Associates, LLC | Institution | 512.750 | 0,17% | 1,56M € | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 512.500 | 0,17% | 1,56M € | 2026-03-31 |
| Envestnet Asset Management, Inc. | Institution | 478.570 | 0,16% | 1,45M € | 2026-03-31 |
| UBS Asset Management AG | Institution | 397.685 | 0,13% | 1,21M € | 2026-03-31 |
| Polymer Capital Management (HK) Limited | Institution | 322.500 | 0,11% | 979,11k € | 2026-03-31 |
| Diversify Wealth Management, LLC | Institution | 318.360 | 0,11% | 966,54k € | 2026-03-31 |
| LPL Financial LLC | Institution | 279.355 | 0,09% | 848,12k € | 2026-03-31 |
| AdvisorShares Investments, LLC | Institution | 251.700 | 0,09% | 764,16k € | 2026-03-31 |