| Redmile Group, LLC | Institution | 297.188.365 | 28,64% | US$ 82,89M | 2026-04-01 |
| Vulpes Investment Management Pte. Ltd. | Institution | 143.537.037 | 13,83% | US$ 40,03M | 2026-04-01 |
| Hargreaves Lansdown Asset Management Ltd. | Institution | 102.743.240 | 9,90% | US$ 28,66M | 2026-04-01 |
| HBOS Investment Fund Managers Limited | Institution | 38.483.720 | 3,71% | US$ 10,73M | 2026-04-01 |
| Union Bancaire Privee Asset Management LLC | Institution | 10.548.682 | 1,02% | US$ 2,94M | 2026-04-01 |
| Artal Group S.A. | Institution | 9.090.909 | 0,88% | US$ 2,54M | 2026-04-01 |
| Invus Public Equities, L.P. | Institution | 9.090.909 | 0,88% | US$ 2,54M | 2026-04-01 |
| Canaccord Genuity Wealth (International) Ltd. | Institution | 7.960.714 | 0,77% | US$ 2,22M | 2026-04-01 |
| Credo Group of Companies | Institution | 7.789.058 | 0,75% | US$ 2,17M | 2026-04-01 |
| IG Group Holdings plc | Institution | 6.446.779 | 0,62% | US$ 1,80M | 2026-04-01 |
| Interactive Brokers Group, Inc. | Institution | 5.928.994 | 0,57% | US$ 1,65M | 2026-04-01 |
| Seneca Partners Limited | Institution | 5.000.000 | 0,48% | US$ 1,39M | 2026-04-01 |
| Panmure Liberum Capital Limited | Institution | 4.787.167 | 0,46% | US$ 1,34M | 2026-04-01 |
| Quintet Asset Management S.A. | Institution | 4.777.583 | 0,46% | US$ 1,33M | 2026-04-01 |
| Calculus Capital Limited | Institution | 4.501.098 | 0,43% | US$ 1,26M | 2026-04-01 |
| JM Finn & Co Ltd. | Institution | 3.954.954 | 0,38% | US$ 1,10M | 2026-04-01 |
| Saxo Bank A/S | Institution | 3.621.898 | 0,35% | US$ 1,01M | 2026-04-01 |
| EQ Investors | Institution | 2.657.633 | 0,26% | US$ 741,21k | 2026-04-01 |
| Raymond James Wealth Management Limited | Institution | 2.549.936 | 0,25% | US$ 711,18k | 2026-04-01 |
| Lloyds Banking Group plc | Institution | 2.516.456 | 0,24% | US$ 701,84k | 2026-04-01 |
| DEGIRO B.V. | Institution | 2.082.302 | 0,20% | US$ 580,75k | 2026-04-01 |
| Forsyth Barr Investment Management Limited | Institution | 2.063.523 | 0,20% | US$ 575,52k | 2026-04-01 |
| Vontobel Asset Management AG | Institution | 1.900.000 | 0,18% | US$ 529,91k | 2026-04-01 |
| Mole Valley Asset Management Ltd | Institution | 1.841.607 | 0,18% | US$ 513,62k | 2026-04-01 |
| Mirabaud Asset Management Ltd. | Institution | 1.479.531 | 0,14% | US$ 412,64k | 2026-04-01 |
| Integrated Financial Arrangements plc | Institution | 1.106.594 | 0,11% | US$ 308,63k | 2026-04-01 |
| NatWest Markets Plc | Institution | 1.046.518 | 0,10% | US$ 291,87k | 2026-04-01 |
| Investec Group | Institution | 1.025.726 | 0,10% | US$ 286,07k | 2026-04-01 |
| GHC Capital Markets Ltd. | Institution | 952.990 | 0,09% | US$ 265,79k | 2026-04-01 |
| Brompton Asset Management LLP | Institution | 852.865 | 0,08% | US$ 237,86k | 2026-04-01 |
| iDealing.com Limited | Institution | 548.920 | 0,05% | US$ 153,09k | 2026-04-01 |
| Spreadex. Com Limited | Institution | 510.000 | 0,05% | US$ 142,24k | 2026-04-01 |
| Church House Investments Ltd. | Institution | 434.800 | 0,04% | US$ 121,27k | 2026-04-01 |
| Hedley & Company Stockbrokers Ltd. | Institution | 433.717 | 0,04% | US$ 120,96k | 2026-04-01 |
| LGT Wealth Management UK LLP | Institution | 382.207 | 0,04% | US$ 106,60k | 2026-04-01 |
| LUKB Expert Fondsleitung AG | Institution | 355.127 | 0,03% | US$ 99,04k | 2026-04-01 |
| Dowgate Capital Limited | Institution | 325.331 | 0,03% | US$ 90,73k | 2026-04-01 |
| Maunby Investment Management Ltd. | Institution | 325.000 | 0,03% | US$ 90,64k | 2026-04-01 |
| Arnold Stansby & Co Limited | Institution | 316.667 | 0,03% | US$ 88,32k | 2026-04-01 |
| CGS International Securities Pte. Ltd. | Institution | 300.000 | 0,03% | US$ 83,67k | 2026-04-01 |
| Ramsey Crookall & Co. Ltd | Institution | 298.000 | 0,03% | US$ 83,11k | 2026-04-01 |
| Wells Fargo Clearing Services, LLC | Institution | 267.000 | 0,03% | US$ 74,47k | 2026-04-01 |
| Society of Lloyd's | Institution | 250.000 | 0,02% | US$ 69,73k | 2026-04-01 |
| Lightsphere Investments Ltd | Institution | 245.000 | 0,02% | US$ 68,33k | 2026-04-01 |
| CMC Markets Stockbroking Ltd. | Institution | 179.420 | 0,02% | US$ 50,04k | 2026-04-01 |