| Alpha Wave Global, LP | Institution | 3.707.757 | 10,57% | US$ 102,48M | 2026-03-31 |
| Commodore Capital LP | Institution | 2.723.196 | 7,76% | US$ 75,27M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 2.064.075 | 5,88% | US$ 57,05M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 2.009.893 | 5,73% | US$ 55,55M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 1.989.393 | 5,67% | US$ 54,99M | 2025-10-03 |
| Armistice Capital Master Fund Ltd. | Institution | 1.536.000 | 4,38% | US$ 42,46M | 2025-12-31 |
| Spruce Street Capital LP | Institution | 1.325.210 | 3,78% | US$ 36,63M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 1.240.053 | 3,53% | US$ 34,28M | 2025-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.170.865 | 3,34% | US$ 32,36M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 1.101.874 | 3,14% | US$ 30,46M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 1.035.551 | 2,95% | US$ 28,62M | 2026-03-31 |
| Armistice Capital LLC | Institution | 912.000 | 2,60% | US$ 25,21M | 2026-03-31 |
| Millennium Management LLC | Institution | 821.982 | 2,34% | US$ 22,72M | 2026-03-31 |
| BlackRock, Inc. | Institution | 666.188 | 1,90% | US$ 18,41M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 515.000 | 1,47% | US$ 14,23M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 500.000 | 1,42% | US$ 13,82M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 500.000 | 1,42% | US$ 13,82M | 2026-03-31 |
| VR Management, LLC | Institution | 500.000 | 1,42% | US$ 13,82M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 486.726 | 1,39% | US$ 13,45M | 2026-03-31 |
| Jennison Associates LLC | Institution | 386.426 | 1,10% | US$ 10,68M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 385.000 | 1,10% | US$ 10,64M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 371.208 | 1,06% | US$ 10,26M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 238.498 | 0,68% | US$ 6,59M | 2026-03-31 |
| Alkeon Capital Management, LLC | Institution | 227.101 | 0,65% | US$ 6,28M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 216.099 | 0,62% | US$ 5,97M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 209.268 | 0,60% | US$ 5,78M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 199.503 | 0,57% | US$ 5,51M | 2026-03-31 |
| Marshall Wace LLP | Institution | 176.347 | 0,50% | US$ 4,87M | 2026-03-31 |
| AWM Investment Company Inc | Institution | 170.000 | 0,48% | US$ 4,70M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 167.500 | 0,48% | US$ 4,63M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 139.304 | 0,40% | US$ 3,85M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 125.168 | 0,36% | US$ 3,46M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 94.022 | 0,27% | US$ 2,60M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 88.999 | 0,25% | US$ 2,46M | 2026-03-31 |
| Almitas Capital LLC | Institution | 78.520 | 0,22% | US$ 2,17M | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 52.653 | 0,15% | US$ 1,46M | 2026-03-31 |
| TD Asset Management, Inc. | Institution | 43.800 | 0,12% | US$ 1,21M | 2026-03-31 |
| AdvisorShares Investments, LLC | Institution | 41.023 | 0,12% | US$ 1,13M | 2026-03-31 |