| Redmile Group, LLC | Institution | 12.604.885 | 9,91% | US$ 13,49M | 2026-04-20 |
| TCG Crossover Management, LLC | Institution | 11.390.175 | 8,96% | US$ 12,19M | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 11.390.175 | 8,96% | US$ 12,19M | 2025-10-27 |
| Prosight Management, LP | Institution | 8.300.000 | 6,53% | US$ 8,88M | 2026-03-31 |
| BlackRock, Inc. | Institution | 6.250.747 | 4,91% | US$ 6,69M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 5.701.655 | 4,48% | US$ 6,10M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 5.597.433 | 4,40% | US$ 5,99M | 2026-03-31 |
| Brookfield Corporation | Institution | 4.409.794 | 3,47% | US$ 4,72M | 2025-09-30 |
| Morgan Stanley | Institution | 3.807.230 | 2,99% | US$ 4,07M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 3.382.129 | 2,66% | US$ 3,62M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.119.154 | 2,45% | US$ 3,34M | 2026-03-31 |
| Prosight Plus Fund, LP | Institution | 2.329.115 | 1,83% | US$ 2,49M | 2024-09-30 |
| The Goldman Sachs Group, Inc. | Institution | 1.603.548 | 1,26% | US$ 1,72M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.566.662 | 1,23% | US$ 1,68M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.325.017 | 1,04% | US$ 1,42M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 1.318.026 | 1,04% | US$ 1,41M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.203.756 | 0,95% | US$ 1,29M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.033.277 | 0,81% | US$ 1,11M | 2026-03-31 |
| L1 Group Limited | Institution | 990.778 | 0,78% | US$ 1,06M | 2026-03-31 |
| BNP Paribas Financial Markets SNC | Institution | 860.491 | 0,68% | US$ 920,73k | 2026-03-31 |
| Blue Owl Capital Inc. | Institution | 733.568 | 0,58% | US$ 784,92k | 2026-03-31 |
| Prosight Fund, LP | Institution | 708.647 | 0,56% | US$ 758,25k | 2024-09-30 |
| PanAgora Asset Management, Inc. | Institution | 691.275 | 0,54% | US$ 739,66k | 2026-03-31 |
| Vantage Consulting Group, Inc. | Institution | 682.998 | 0,54% | US$ 730,81k | 2025-12-31 |
| Two Sigma Investments, LP | Institution | 668.022 | 0,53% | US$ 714,78k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 552.201 | 0,43% | US$ 590,86k | 2026-03-31 |
| Voleon Capital Management LP | Institution | 513.831 | 0,40% | US$ 549,80k | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 488.817 | 0,38% | US$ 523,03k | 2026-03-31 |
| UBS Asset Management AG | Institution | 458.902 | 0,36% | US$ 491,03k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 449.122 | 0,35% | US$ 480,56k | 2026-03-31 |
| Schroder Investment Management Limited | Institution | 418.782 | 0,33% | US$ 448,10k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 399.721 | 0,31% | US$ 427,70k | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 299.278 | 0,24% | US$ 320,23k | 2026-03-31 |
| Wells Fargo & Company | Institution | 262.783 | 0,21% | US$ 281,18k | 2026-03-31 |
| Lazard Asset Management LLC | Institution | 262.595 | 0,21% | US$ 280,98k | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 254.909 | 0,20% | US$ 272,75k | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 243.176 | 0,19% | US$ 260,20k | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 234.261 | 0,18% | US$ 250,66k | 2026-03-31 |
| Wellington Management Group LLP | Institution | 231.064 | 0,18% | US$ 247,24k | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 224.361 | 0,18% | US$ 240,07k | 2026-03-31 |