| EcoR1 Capital, LLC | Institution | 22.970.388 | 31,46% | US$ 621,81M | 2026-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 21.582.563 | 29,56% | US$ 584,24M | 2025-11-16 |
| Rubric Capital Management LP | Institution | 7.000.000 | 9,59% | US$ 189,49M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.553.888 | 6,24% | US$ 123,27M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 3.974.579 | 5,44% | US$ 107,59M | 2026-04-08 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 3.974.579 | 5,44% | US$ 107,59M | 2026-04-08 |
| BVF Partners L.P. | Institution | 3.734.142 | 5,11% | US$ 101,08M | 2026-03-31 |
| Redmile Biopharma Investments III, L.P. | Institution | 3.470.727 | 4,75% | US$ 93,95M | 2024-12-31 |
| Morgan Stanley | Institution | 2.404.850 | 3,29% | US$ 65,10M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 2.045.162 | 2,80% | US$ 55,36M | 2025-09-30 |
| BNPP Asset Management Holding | Institution | 1.750.011 | 2,40% | US$ 47,37M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 1.705.580 | 2,34% | US$ 46,17M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 1.601.489 | 2,19% | US$ 43,35M | 2025-09-30 |
| EcoR1 Capital Fund, L.P. | Institution | 1.387.825 | 1,90% | US$ 37,57M | 2025-11-16 |
| Citadel Advisors LLC | Institution | 1.150.018 | 1,57% | US$ 31,13M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.139.135 | 1,56% | US$ 30,84M | 2026-03-31 |
| Nextech Invest Ltd. | Institution | 1.113.946 | 1,53% | US$ 30,15M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 1.011.777 | 1,39% | US$ 27,39M | 2026-03-31 |
| Capricorn Fund Managers (Pty) Ltd. | Institution | 1.007.210 | 1,38% | US$ 27,27M | 2026-03-31 |
| Deutsche Asset & Wealth Management | Institution | 912.250 | 1,25% | US$ 24,69M | 2026-03-31 |
| Arrowstreet Capital, Limited Partnership | Institution | 743.898 | 1,02% | US$ 20,14M | 2026-03-31 |
| Assenagon Asset Management S.A. | Institution | 727.986 | 1,00% | US$ 19,71M | 2026-03-31 |
| FMR LLC | Institution | 666.877 | 0,91% | US$ 18,05M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 659.940 | 0,90% | US$ 17,86M | 2026-03-31 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 629.751 | 0,86% | US$ 17,05M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 565.249 | 0,77% | US$ 15,30M | 2026-03-31 |
| Prosight Management, LP | Institution | 539.049 | 0,74% | US$ 14,59M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 511.937 | 0,70% | US$ 13,86M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 499.875 | 0,68% | US$ 13,53M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 497.369 | 0,68% | US$ 13,46M | 2026-03-31 |
| Redmile Group, LLC | Institution | 491.654 | 0,67% | US$ 13,31M | 2026-03-31 |
| UBS Asset Management AG | Institution | 491.164 | 0,67% | US$ 13,30M | 2026-03-31 |
| Hillsdale Investment Management Inc. | Institution | 345.622 | 0,47% | US$ 9,36M | 2026-03-31 |
| First Trust Advisors LP | Institution | 340.270 | 0,47% | US$ 9,21M | 2026-06-30 |
| Crestline Investors Inc. | Institution | 321.427 | 0,44% | US$ 8,70M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 320.210 | 0,44% | US$ 8,67M | 2026-03-31 |
| Royce & Associates, LP | Institution | 299.202 | 0,41% | US$ 8,10M | 2026-03-31 |
| Picton Mahoney Asset Management | Institution | 256.690 | 0,35% | US$ 6,95M | 2026-03-31 |