| Athanor Capital, LP | Institution | 11.581.402 | 12,19% | US$ 57,96M | 2026-01-23 |
| Suvretta Capital Management, LLC | Institution | 9.067.001 | 9,54% | US$ 45,38M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 8.372.230 | 8,81% | US$ 41,90M | 2026-03-31 |
| VR Management, LLC | Institution | 6.434.990 | 6,77% | US$ 32,21M | 2026-03-31 |
| Venrock Healthcare Capital Partners Fund, L.P. | Institution | 5.023.167 | 5,29% | US$ 25,14M | 2025-04-01 |
| JPMorgan Chase & Co. | Institution | 4.471.316 | 4,71% | US$ 22,38M | 2026-04-30 |
| Great Point Partners, LLC | Institution | 4.215.930 | 4,44% | US$ 21,10M | 2026-03-31 |
| Braidwell LP | Institution | 3.988.989 | 4,20% | US$ 19,96M | 2026-03-31 |
| Artal Group S.A. | Institution | 3.734.866 | 3,93% | US$ 18,69M | 2026-03-31 |
| Commodore Capital LP | Institution | 3.250.000 | 3,42% | US$ 16,27M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 3.217.503 | 3,39% | US$ 16,10M | 2024-12-31 |
| Pfizer Venture Investments LLC | Institution | 2.838.913 | 2,99% | US$ 14,21M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 2.750.000 | 2,89% | US$ 13,76M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 2.564.303 | 2,70% | US$ 12,83M | 2026-03-31 |
| Biomedical Value Fund | Institution | 2.124.030 | 2,24% | US$ 10,63M | 2025-05-08 |
| ADAR1 Partners, LP | Institution | 1.578.787 | 1,66% | US$ 7,90M | 2024-12-31 |
| Millennium Management LLC | Institution | 1.508.063 | 1,59% | US$ 7,55M | 2026-03-31 |
| Armistice Capital LLC | Institution | 1.507.000 | 1,59% | US$ 7,54M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 1.450.000 | 1,53% | US$ 7,26M | 2026-03-31 |
| QVT Financial LP | Institution | 1.310.593 | 1,38% | US$ 6,56M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 1.193.492 | 1,26% | US$ 5,97M | 2026-03-31 |
| EcoR1 Capital, LLC | Institution | 1.179.715 | 1,24% | US$ 5,90M | 2026-03-31 |
| Biomedical Offshore Value Fund, LTD. | Institution | 1.046.164 | 1,10% | US$ 5,24M | 2025-05-08 |
| Boxer Capital Management, LLC | Institution | 900.000 | 0,95% | US$ 4,50M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 872.662 | 0,92% | US$ 4,37M | 2026-03-31 |
| Morgan Stanley | Institution | 868.280 | 0,91% | US$ 4,35M | 2026-03-31 |
| Marshall Wace LLP | Institution | 852.340 | 0,90% | US$ 4,27M | 2026-03-31 |
| StemPoint Capital LP | Institution | 753.520 | 0,79% | US$ 3,77M | 2026-03-31 |
| Saturn V Capital Management LP | Institution | 739.960 | 0,78% | US$ 3,70M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 630.403 | 0,66% | US$ 3,16M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 560.651 | 0,59% | US$ 2,81M | 2026-03-31 |
| FMR LLC | Institution | 529.346 | 0,56% | US$ 2,65M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 527.691 | 0,56% | US$ 2,64M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 511.000 | 0,54% | US$ 2,56M | 2026-03-31 |
| Spearhead Insurance Solutions Idf, Llc | Institution | 498.464 | 0,52% | US$ 2,49M | 2024-12-31 |
| Vanguard Capital Management, LLC | Institution | 486.850 | 0,51% | US$ 2,44M | 2026-03-31 |
| BlackRock, Inc. | Institution | 457.359 | 0,48% | US$ 2,29M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 450.311 | 0,47% | US$ 2,25M | 2026-03-31 |
| Foresite Capital Management, LLC | Institution | 450.000 | 0,47% | US$ 2,25M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 374.506 | 0,39% | US$ 1,87M | 2026-03-31 |
| Kvp Capital Advisors, LP | Institution | 373.128 | 0,39% | US$ 1,87M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 318.186 | 0,33% | US$ 1,59M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 313.300 | 0,33% | US$ 1,57M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 278.890 | 0,29% | US$ 1,40M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 259.014 | 0,27% | US$ 1,30M | 2025-09-30 |
| UBS Asset Management AG | Institution | 241.027 | 0,25% | US$ 1,21M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 231.862 | 0,24% | US$ 1,16M | 2026-03-31 |