| OrbiMed Advisors LLC | Institution | 3.060.000 | 7,46% | US$ 2,33M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 2.071.304 | 5,05% | US$ 1,57M | 2026-03-31 |
| TCG Crossover Fund II, L.P. | Institution | 2.071.304 | 5,05% | US$ 1,57M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.953.045 | 4,76% | US$ 1,48M | 2025-12-31 |
| Vanguard Capital Management, LLC | Institution | 1.574.200 | 3,84% | US$ 1,20M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 751.141 | 1,83% | US$ 570,87k | 2026-03-31 |
| TCG Crossover Fund I, L.P. | Institution | 669.145 | 1,63% | US$ 508,55k | 2026-03-31 |
| The Column Group, LLC | Institution | 669.145 | 1,63% | US$ 508,55k | 2026-03-31 |
| StemPoint Capital LP | Institution | 616.749 | 1,50% | US$ 468,73k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 589.663 | 1,44% | US$ 448,14k | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 519.077 | 1,27% | US$ 394,50k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 469.619 | 1,14% | US$ 356,91k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 453.391 | 1,10% | US$ 344,58k | 2026-03-31 |
| BlackRock, Inc. | Institution | 448.507 | 1,09% | US$ 340,87k | 2026-03-31 |
| Millennium Management LLC | Institution | 430.404 | 1,05% | US$ 327,11k | 2026-03-31 |
| Luminus Management, LLC | Institution | 396.053 | 0,97% | US$ 301,00k | 2026-03-31 |
| Citadel Multi-Strategy Equities Master Fund Ltd. | Institution | 297.460 | 0,72% | US$ 226,07k | 2024-09-30 |
| Renaissance Technologies LLC | Institution | 291.300 | 0,71% | US$ 221,39k | 2026-03-31 |
| AdvisorShares Investments, LLC | Institution | 277.110 | 0,68% | US$ 210,60k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 272.811 | 0,66% | US$ 207,34k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 217.700 | 0,53% | US$ 165,45k | 2026-03-31 |
| Verdad Advisers, L.P. | Institution | 184.938 | 0,45% | US$ 140,55k | 2026-03-31 |
| XTX Markets Limited | Institution | 152.849 | 0,37% | US$ 116,17k | 2026-03-31 |
| Shay Capital LLC | Institution | 144.452 | 0,35% | US$ 109,78k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 142.607 | 0,35% | US$ 108,38k | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 134.571 | 0,33% | US$ 102,27k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 121.114 | 0,30% | US$ 92,05k | 2026-03-31 |
| Tudor Investment Corporation | Institution | 106.172 | 0,26% | US$ 80,69k | 2026-03-31 |
| Diadema Partners LP | Institution | 105.428 | 0,26% | US$ 80,13k | 2026-03-31 |
| Abaris Investment Management AG | Institution | 92.000 | 0,22% | US$ 69,92k | 2025-12-31 |
| Simplex Trading, LLC | Institution | 89.649 | 0,22% | US$ 68,13k | 2026-03-31 |
| UBS Asset Management AG | Institution | 78.736 | 0,19% | US$ 59,84k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 72.655 | 0,18% | US$ 55,22k | 2026-03-31 |
| PGIM, Inc. | Institution | 53.100 | 0,13% | US$ 40,36k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 49.842 | 0,12% | US$ 37,88k | 2026-03-31 |
| Citadel Securities LLC | Institution | 38.425 | 0,09% | US$ 29,20k | 2024-09-30 |
| BBVA Asset Management, S.A., S.G.I.I.C | Institution | 29.947 | 0,07% | US$ 22,76k | 2025-06-30 |
| Persistent Asset Partners Limited | Institution | 26.612 | 0,06% | US$ 20,23k | 2026-03-31 |