| Lynx1 Capital Management LP | Institution | 8.019.148 | 12,27% | US$ 8,58M | 2026-03-31 |
| Lynx1 Master Fund LP | Institution | 8.019.148 | 12,27% | US$ 8,58M | 2025-12-23 |
| BVF Partners L.P. | Institution | 5.564.290 | 8,51% | US$ 5,95M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 3.000.269 | 4,59% | US$ 3,21M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 2.784.792 | 4,26% | US$ 2,98M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.154.256 | 3,30% | US$ 2,31M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 1.868.548 | 2,86% | US$ 2,00M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.840.952 | 2,82% | US$ 1,97M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.460.285 | 2,23% | US$ 1,56M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.364.783 | 2,09% | US$ 1,46M | 2026-03-31 |
| Deer Management Co. LLC | Institution | 1.245.504 | 1,91% | US$ 1,33M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.209.009 | 1,85% | US$ 1,29M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 918.020 | 1,40% | US$ 982,28k | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 808.356 | 1,24% | US$ 864,94k | 2026-03-31 |
| DC Investments Management, LLC | Institution | 665.563 | 1,02% | US$ 712,15k | 2026-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 623.967 | 0,95% | US$ 667,64k | 2025-03-31 |
| Geode Capital Management, LLC | Institution | 616.952 | 0,94% | US$ 660,14k | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 560.400 | 0,86% | US$ 599,63k | 2026-03-31 |
| K2 HealthVentures | Institution | 467.904 | 0,72% | US$ 500,66k | 2024-12-31 |
| GSA Capital Partners LLP | Institution | 378.960 | 0,58% | US$ 405,49k | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 319.587 | 0,49% | US$ 341,96k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 318.411 | 0,49% | US$ 340,70k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 305.772 | 0,47% | US$ 327,18k | 2026-03-31 |
| Marshall Wace LLP | Institution | 237.346 | 0,36% | US$ 253,96k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 207.313 | 0,32% | US$ 221,82k | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 201.987 | 0,31% | US$ 216,13k | 2026-03-31 |
| Morgan Stanley | Institution | 173.643 | 0,27% | US$ 185,80k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 157.228 | 0,24% | US$ 168,23k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 144.421 | 0,22% | US$ 154,53k | 2026-03-31 |
| Brown Brothers Harriman & Co. | Institution | 143.051 | 0,22% | US$ 153,06k | 2026-03-31 |
| Verdad Advisers, L.P. | Institution | 134.001 | 0,21% | US$ 143,38k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 111.900 | 0,17% | US$ 119,73k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 97.448 | 0,15% | US$ 104,27k | 2026-03-31 |
| Letko, Brosseau & Associates Inc. | Institution | 95.875 | 0,15% | US$ 102,59k | 2026-03-31 |
| NewEdge Wealth, LLC | Institution | 91.463 | 0,14% | US$ 97,87k | 2026-03-31 |
| Nationwide Fund Advisors | Institution | 73.200 | 0,11% | US$ 78,32k | 2026-04-30 |
| Stifel Asset Management Corp. | Institution | 69.400 | 0,11% | US$ 74,26k | 2026-03-31 |