| BVF Partners L.P. | Institution | 1.251.788 | 7,56% | US$ 35,90M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.069.519 | 6,46% | US$ 30,67M | 2026-03-31 |
| Samsara BioCapital LLC | Institution | 1.062.872 | 6,42% | US$ 30,48M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 946.829 | 5,71% | US$ 27,16M | 2026-04-24 |
| Point72 Associates, LLC | Institution | 946.829 | 5,71% | US$ 27,16M | 2026-04-24 |
| Perceptive Advisors LLC | Institution | 898.025 | 5,42% | US$ 25,76M | 2026-04-14 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 898.025 | 5,42% | US$ 25,76M | 2026-04-14 |
| Kynam Capital Management, LP | Institution | 872.558 | 5,27% | US$ 25,02M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 801.144 | 4,84% | US$ 22,98M | 2026-03-31 |
| Affinity Healthcare Fund, LP | Institution | 748.382 | 4,52% | US$ 21,46M | 2026-01-22 |
| Vanguard Capital Management, LLC | Institution | 720.442 | 4,35% | US$ 20,66M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 715.307 | 4,32% | US$ 20,52M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 715.307 | 4,32% | US$ 20,52M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 668.693 | 4,04% | US$ 19,18M | 2026-02-18 |
| Samsara Opportunity Fund, L.P. | Institution | 643.777 | 3,89% | US$ 18,46M | 2026-02-11 |
| ADAR1 Capital Management, LLC | Institution | 524.441 | 3,17% | US$ 15,04M | 2026-03-31 |
| Velan Capital Partners LP | Institution | 512.160 | 3,09% | US$ 14,69M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 488.916 | 2,95% | US$ 14,02M | 2026-02-18 |
| Balyasny Asset Management L.P. | Institution | 465.792 | 2,81% | US$ 13,36M | 2026-03-31 |
| Woodline Partners LP | Institution | 457.441 | 2,76% | US$ 13,12M | 2026-03-31 |
| Samsara Biocapital, L.P. | Institution | 419.095 | 2,53% | US$ 12,02M | 2026-02-11 |
| UBS Asset Management AG | Institution | 392.871 | 2,37% | US$ 11,27M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 335.813 | 2,03% | US$ 9,63M | 2026-03-31 |
| MRL Ventures Fund LLC | Institution | 272.351 | 1,64% | US$ 7,81M | 2026-03-31 |
| Acuta Capital Partners, LLC | Institution | 269.425 | 1,63% | US$ 7,73M | 2026-03-31 |
| BlackRock, Inc. | Institution | 232.684 | 1,40% | US$ 6,67M | 2026-03-31 |
| Kvp Capital Advisors, LP | Institution | 226.575 | 1,37% | US$ 6,50M | 2026-03-31 |
| Marshall Wace LLP | Institution | 222.634 | 1,34% | US$ 6,39M | 2026-03-31 |
| Millennium Management LLC | Institution | 210.378 | 1,27% | US$ 6,03M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 200.000 | 1,21% | US$ 5,74M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 190.671 | 1,15% | US$ 5,47M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 171.386 | 1,03% | US$ 4,92M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 129.608 | 0,78% | US$ 3,72M | 2024-09-30 |
| Citadel Advisors LLC | Institution | 117.537 | 0,71% | US$ 3,37M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 97.824 | 0,59% | US$ 2,81M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 94.838 | 0,57% | US$ 2,72M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 84.902 | 0,51% | US$ 2,43M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 75.359 | 0,45% | US$ 2,16M | 2026-02-18 |
| Eversept Partners, L.P. | Institution | 73.161 | 0,44% | US$ 2,10M | 2026-03-31 |
| Burkehill Global Management, LP | Institution | 71.530 | 0,43% | US$ 2,05M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 65.176 | 0,39% | US$ 1,87M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 52.118 | 0,31% | US$ 1,49M | 2026-03-31 |
| Mr. William Newell | Insider | 40.906 | 0,25% | US$ 1,17M | 2025-03-31 |
| Fisher Asset Management, LLC | Institution | 35.295 | 0,21% | US$ 1,01M | 2026-03-31 |
| Trexquant Investment LP | Institution | 34.343 | 0,21% | US$ 984,96k | 2026-03-31 |