| BVF Partners L.P. | Institution | 1.251.788 | 7,55% | US$ 36,99M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.069.519 | 6,45% | US$ 31,60M | 2026-03-31 |
| Samsara BioCapital LLC | Institution | 1.062.872 | 6,41% | US$ 31,41M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 946.829 | 5,71% | US$ 27,98M | 2026-04-24 |
| Point72 Asset Management, L.P. | Institution | 946.829 | 5,71% | US$ 27,98M | 2026-04-24 |
| Perceptive Advisors LLC | Institution | 898.025 | 5,42% | US$ 26,54M | 2026-04-14 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 898.025 | 5,42% | US$ 26,54M | 2026-04-14 |
| Kynam Capital Management, LP | Institution | 872.558 | 5,27% | US$ 25,78M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 801.144 | 4,83% | US$ 23,67M | 2026-03-31 |
| Affinity Healthcare Fund, LP | Institution | 748.382 | 4,52% | US$ 22,11M | 2026-01-22 |
| Vanguard Capital Management, LLC | Institution | 720.442 | 4,35% | US$ 21,29M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 715.307 | 4,32% | US$ 21,14M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 715.307 | 4,32% | US$ 21,14M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 668.693 | 4,04% | US$ 19,76M | 2026-02-18 |
| Samsara Opportunity Fund, L.P. | Institution | 643.777 | 3,89% | US$ 19,02M | 2026-02-11 |
| ADAR1 Capital Management, LLC | Institution | 524.441 | 3,16% | US$ 15,50M | 2026-03-31 |
| Velan Capital Partners LP | Institution | 512.160 | 3,09% | US$ 15,13M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 488.916 | 2,95% | US$ 14,45M | 2026-02-18 |
| Balyasny Asset Management L.P. | Institution | 465.792 | 2,81% | US$ 13,76M | 2026-03-31 |
| Woodline Partners LP | Institution | 457.441 | 2,76% | US$ 13,52M | 2026-03-31 |
| Samsara Biocapital, L.P. | Institution | 419.095 | 2,53% | US$ 12,38M | 2026-02-11 |
| UBS Asset Management AG | Institution | 392.871 | 2,37% | US$ 11,61M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 335.813 | 2,03% | US$ 9,92M | 2026-03-31 |
| MRL Ventures Fund LLC | Institution | 272.351 | 1,64% | US$ 8,05M | 2026-03-31 |
| Acuta Capital Partners, LLC | Institution | 269.425 | 1,63% | US$ 7,96M | 2026-03-31 |
| BlackRock, Inc. | Institution | 232.684 | 1,40% | US$ 6,88M | 2026-03-31 |
| Kvp Capital Advisors, LP | Institution | 226.575 | 1,37% | US$ 6,70M | 2026-03-31 |
| Marshall Wace LLP | Institution | 222.634 | 1,34% | US$ 6,58M | 2026-03-31 |
| Millennium Management LLC | Institution | 210.378 | 1,27% | US$ 6,22M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 200.000 | 1,21% | US$ 5,91M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 190.671 | 1,15% | US$ 5,63M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 171.386 | 1,03% | US$ 5,06M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 129.608 | 0,78% | US$ 3,83M | 2024-09-30 |
| Citadel Advisors LLC | Institution | 117.537 | 0,71% | US$ 3,47M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 97.824 | 0,59% | US$ 2,89M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 94.838 | 0,57% | US$ 2,80M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 84.902 | 0,51% | US$ 2,51M | 2026-03-31 |
| Biotechnology Value Trading Fund OS LP | Institution | 75.359 | 0,45% | US$ 2,23M | 2026-02-18 |
| Eversept Partners, L.P. | Institution | 73.161 | 0,44% | US$ 2,16M | 2026-03-31 |
| Burkehill Global Management, LP | Institution | 71.530 | 0,43% | US$ 2,11M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 65.176 | 0,39% | US$ 1,93M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 52.118 | 0,31% | US$ 1,54M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 47.188 | 0,28% | US$ 1,39M | 2026-05-31 |
| Mr. William Newell | Insider | 40.906 | 0,25% | US$ 1,21M | 2025-03-31 |