| Mr. Robert Duggan | Insider | 573.883.879 | 73,94% | US$ 8,25B | 2026-06-12 |
| Baker Bros. Advisors LP | Institution | 36.391.063 | 4,69% | US$ 523,30M | 2026-03-31 |
| FMR LLC | Institution | 10.852.786 | 1,40% | US$ 156,06M | 2026-03-31 |
| BlackRock, Inc. | Institution | 9.653.758 | 1,24% | US$ 138,82M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 8.277.859 | 1,07% | US$ 119,04M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 7.028.160 | 0,91% | US$ 101,06M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 5.711.802 | 0,74% | US$ 82,14M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 5.233.252 | 0,67% | US$ 75,25M | 2026-03-31 |
| UBS Asset Management AG | Institution | 3.760.011 | 0,48% | US$ 54,07M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 3.315.854 | 0,43% | US$ 47,68M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 2.242.229 | 0,29% | US$ 32,24M | 2026-03-31 |
| Morgan Stanley | Institution | 1.562.704 | 0,20% | US$ 22,47M | 2026-03-31 |
| Norges Bank Investment Management | Institution | 1.373.943 | 0,18% | US$ 19,76M | 2025-12-31 |
| Pictet Asset Management Limited | Institution | 1.323.179 | 0,17% | US$ 19,03M | 2026-03-31 |
| Apeiron Capital Limited | Institution | 1.309.141 | 0,17% | US$ 18,83M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 981.185 | 0,13% | US$ 14,11M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 960.867 | 0,12% | US$ 13,82M | 2026-03-31 |
| TD Asset Management, Inc. | Institution | 956.894 | 0,12% | US$ 13,76M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 934.394 | 0,12% | US$ 13,44M | 2026-03-31 |
| Superstring Capital Management LP | Institution | 892.873 | 0,12% | US$ 12,84M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 784.186 | 0,10% | US$ 11,28M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 710.000 | 0,09% | US$ 10,21M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 665.364 | 0,09% | US$ 9,57M | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 613.877 | 0,08% | US$ 8,83M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 603.933 | 0,08% | US$ 8,68M | 2026-03-31 |
| Bank of America Corporation | Institution | 598.692 | 0,08% | US$ 8,61M | 2026-03-31 |
| Manulife Asset Management | Institution | 592.810 | 0,08% | US$ 8,52M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 581.600 | 0,07% | US$ 8,36M | 2026-03-31 |