| RA Capital Management, L.P. | Institution | 10.071.712 | 22,31% | US$ 443,05M | 2026-04-21 |
| RA Capital Healthcare Fund, L.P. | Institution | 6.905.625 | 15,29% | US$ 303,78M | 2026-04-21 |
| TPG Capital, L.P. | Institution | 6.684.962 | 14,81% | US$ 294,07M | 2026-04-21 |
| Atlas Venture Advisors, Inc. | Institution | 3.084.480 | 6,83% | US$ 135,69M | 2026-04-21 |
| Viking Global Investors LP | Institution | 2.952.754 | 6,54% | US$ 129,89M | 2026-04-21 |
| OrbiMed Advisors LLC | Institution | 2.671.721 | 5,92% | US$ 117,53M | 2026-05-27 |
| Orbimed Private Investments VIII, LP | Institution | 2.671.721 | 5,92% | US$ 117,53M | 2026-05-27 |
| Atlas Venture Fund XI, L.P. | Institution | 2.382.495 | 5,28% | US$ 104,81M | 2026-04-21 |
| RA Capital Nexus Fund III, L.P. | Institution | 2.240.708 | 4,96% | US$ 98,57M | 2026-04-21 |
| Qatar Holding LLC | Institution | 2.020.258 | 4,47% | US$ 88,87M | 2026-03-31 |
| Viking Global Opportunities Illiquid Investments Sub-Master LP | Institution | 1.894.346 | 4,20% | US$ 83,33M | 2026-04-21 |
| Jennison Associates LLC | Institution | 1.451.220 | 3,21% | US$ 63,84M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 1.433.908 | 3,18% | US$ 63,08M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.295.867 | 2,87% | US$ 57,01M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.166.931 | 2,58% | US$ 51,33M | 2026-03-31 |
| Viking Global Opportunities Drawdown (Aggregator) LP | Institution | 1.058.408 | 2,34% | US$ 46,56M | 2026-04-21 |
| Deerfield Management Company, L.P. | Institution | 970.590 | 2,15% | US$ 42,70M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 756.227 | 1,67% | US$ 33,27M | 2026-03-31 |
| RA Capital Nexus Fund, L.P. | Institution | 715.988 | 1,59% | US$ 31,50M | 2026-04-21 |
| Atlas Venture Opportunity Fund II, L.P. | Institution | 701.985 | 1,55% | US$ 30,88M | 2026-04-21 |
| Perceptive Advisors LLC | Institution | 658.439 | 1,46% | US$ 28,96M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 645.530 | 1,43% | US$ 28,40M | 2026-03-31 |
| Mr. Michael Cloonan | Insider | 547.343 | 1,21% | US$ 24,08M | 2026-04-21 |
| Baker Bros. Advisors LP | Institution | 400.000 | 0,89% | US$ 17,60M | 2026-03-31 |
| Artal Group S.A. | Institution | 300.000 | 0,66% | US$ 13,20M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 294.340 | 0,65% | US$ 12,95M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 293.500 | 0,65% | US$ 12,91M | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 255.636 | 0,57% | US$ 11,25M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 255.554 | 0,57% | US$ 11,24M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 236.813 | 0,52% | US$ 10,42M | 2026-03-31 |
| Kalehua Capital Management LLC | Institution | 197.072 | 0,44% | US$ 8,67M | 2026-03-31 |
| PGIM Securities Investment Trust Enterprise | Institution | 167.152 | 0,37% | US$ 7,35M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 150.000 | 0,33% | US$ 6,60M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 147.833 | 0,33% | US$ 6,50M | 2025-02-07 |
| Blackwell Partners LLC Series A | Institution | 147.833 | 0,33% | US$ 6,50M | 2025-02-07 |
| UBS Asset Management AG | Institution | 147.757 | 0,33% | US$ 6,50M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 142.081 | 0,31% | US$ 6,25M | 2026-03-31 |