| Squadron Master Fund LP | Institution | 951.087 | 9,58% | US$ 3,61M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 951.086 | 9,58% | US$ 3,61M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 944.293 | 9,51% | US$ 3,59M | 2026-03-31 |
| Biomedical Value Fund | Institution | 623.234 | 6,28% | US$ 2,37M | 2026-03-31 |
| Avidity Private Master Fund I LP | Institution | 446.727 | 4,50% | US$ 1,70M | 2025-12-31 |
| Federated Hermes, Inc. | Institution | 441.656 | 4,45% | US$ 1,68M | 2025-12-31 |
| Biomedical Offshore Value Fund, LTD. | Institution | 321.060 | 3,23% | US$ 1,22M | 2026-03-31 |
| Heights Capital Management, Inc. | Institution | 260.870 | 2,63% | US$ 991,31k | 2026-03-31 |
| Avidity Partners Management, L.P. | Institution | 260.207 | 2,62% | US$ 988,79k | 2026-03-31 |
| Kingdon Capital Management, L.L.C. | Institution | 247.811 | 2,50% | US$ 941,68k | 2026-03-31 |
| M. Kingdon Offshore Master Fund L.P. | Institution | 247.811 | 2,50% | US$ 941,68k | 2025-09-30 |
| Empery Asset Management, LP | Institution | 230.978 | 2,33% | US$ 877,72k | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 195.549 | 1,97% | US$ 743,09k | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 135.869 | 1,37% | US$ 516,30k | 2026-03-31 |
| Avidity Master Fund LP | Institution | 106.594 | 1,07% | US$ 405,06k | 2025-12-31 |
| Dr. David Angulo | Insider | 98.935 | 1,00% | US$ 375,95k | 2026-04-01 |
| Acadian Asset Management LLC | Institution | 91.494 | 0,92% | US$ 347,68k | 2026-03-31 |
| Millennium Management LLC | Institution | 77.770 | 0,78% | US$ 295,53k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 60.796 | 0,61% | US$ 231,02k | 2026-03-31 |
| BlackRock, Inc. | Institution | 41.524 | 0,42% | US$ 157,79k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 31.016 | 0,31% | US$ 117,86k | 2026-03-31 |
| AMH Equity, Ltd. | Institution | 30.742 | 0,31% | US$ 116,82k | 2025-09-30 |
| Mr. Scott Sukenick | Insider | 29.968 | 0,30% | US$ 113,88k | 2026-01-29 |
| Vanguard Fiduciary Trust Company | Institution | 28.217 | 0,28% | US$ 107,22k | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 28.080 | 0,28% | US$ 106,70k | 2026-03-31 |
| Yakira Capital Management, Inc. | Institution | 23.575 | 0,24% | US$ 89,59k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 16.353 | 0,16% | US$ 62,14k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 15.091 | 0,15% | US$ 57,35k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 11.947 | 0,12% | US$ 45,40k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 10.942 | 0,11% | US$ 41,58k | 2026-03-31 |
| Wealth Effects LLC | Institution | 10.937 | 0,11% | US$ 41,56k | 2026-03-31 |
| Mr. Ivor Macleod | Insider | 10.050 | 0,10% | US$ 38,19k | 2026-01-29 |
| Nierenberg Investment Management Company, LLC | Institution | 9.444 | 0,10% | US$ 35,89k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 7.142 | 0,07% | US$ 27,14k | 2026-03-31 |
| Mr. Guy MacDonald | Insider | 6.875 | 0,07% | US$ 26,13k | 2025-06-26 |
| XTX Markets Limited | Institution | 6.535 | 0,07% | US$ 24,83k | 2026-03-31 |
| Mr. Brian Tinmouth | Insider | 6.375 | 0,06% | US$ 24,23k | 2025-06-26 |
| Mr. Armando Anido | Insider | 6.000 | 0,06% | US$ 22,80k | 2025-06-26 |
| Dr. Steven Gilman | Insider | 5.875 | 0,06% | US$ 22,33k | 2025-06-26 |
| Dr. Ann Hanham | Insider | 5.828 | 0,06% | US$ 22,15k | 2025-06-26 |
| Mr. David Hastings | Insider | 5.773 | 0,06% | US$ 21,94k | 2025-06-26 |
| LPL Financial LLC | Institution | 4.810 | 0,05% | US$ 18,28k | 2026-03-31 |