| Baker Bros. Advisors LP | Institution | 11.045.336 | 13,38% | US$ 109,02M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 10.116.095 | 12,25% | US$ 99,85M | 2025-06-30 |
| RTW Investments, LP | Institution | 7.356.916 | 8,91% | US$ 72,61M | 2026-03-31 |
| Ridgeback Capital Management LLC | Institution | 6.252.651 | 7,57% | US$ 61,71M | 2026-05-14 |
| BlackRock, Inc. | Institution | 6.239.239 | 7,56% | US$ 61,58M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.462.500 | 5,40% | US$ 44,04M | 2025-07-30 |
| Suvretta Capital Management, LLC | Institution | 4.221.836 | 5,11% | US$ 41,67M | 2026-03-31 |
| Forbion Capital Fund III | Institution | 3.970.668 | 4,81% | US$ 39,19M | 2024-12-31 |
| State Street Global Advisors, Inc. | Institution | 3.782.237 | 4,58% | US$ 37,33M | 2026-03-31 |
| Forbion Capital Partners B.V. | Institution | 2.808.368 | 3,40% | US$ 27,72M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.759.120 | 3,34% | US$ 27,23M | 2026-03-31 |
| Omega Fund IV L.P. | Institution | 2.461.319 | 2,98% | US$ 24,29M | 2024-09-30 |
| D. E. Shaw & Co., L.P. | Institution | 2.336.528 | 2,83% | US$ 23,06M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 2.142.145 | 2,59% | US$ 21,14M | 2026-03-31 |
| Erste Asset Management GmbH | Institution | 2.120.000 | 2,57% | US$ 20,92M | 2026-03-31 |
| FMR LLC | Institution | 2.045.490 | 2,48% | US$ 20,19M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.801.525 | 2,18% | US$ 17,78M | 2026-03-31 |
| The Toronto-Dominion Bank | Institution | 1.591.030 | 1,93% | US$ 15,70M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 1.582.987 | 1,92% | US$ 15,62M | 2026-03-31 |
| Cowen Inc. | Institution | 1.372.052 | 1,66% | US$ 13,54M | 2025-09-30 |
| Mr. Philip Astley-Sparke | Insider | 1.291.521 | 1,56% | US$ 12,75M | 2026-04-01 |
| Boxer Capital Management, LLC | Institution | 1.175.000 | 1,42% | US$ 11,60M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.140.099 | 1,38% | US$ 11,25M | 2026-03-31 |
| EcoR1 Capital, LLC | Institution | 1.000.000 | 1,21% | US$ 9,87M | 2026-03-31 |
| 667, L.P. | Institution | 929.241 | 1,13% | US$ 9,17M | 2025-06-30 |
| Susquehanna International Group, LLP | Institution | 776.807 | 0,94% | US$ 7,67M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 720.036 | 0,87% | US$ 7,11M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 714.225 | 0,86% | US$ 7,05M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 707.426 | 0,86% | US$ 6,98M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 611.759 | 0,74% | US$ 6,04M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 589.120 | 0,71% | US$ 5,81M | 2026-03-31 |
| UBS Asset Management AG | Institution | 581.598 | 0,70% | US$ 5,74M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 552.576 | 0,67% | US$ 5,45M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 475.126 | 0,58% | US$ 4,69M | 2026-03-31 |
| Caption Management, LLC | Institution | 451.822 | 0,55% | US$ 4,46M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 428.145 | 0,52% | US$ 4,23M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 398.729 | 0,48% | US$ 3,94M | 2026-03-31 |