| Suvretta Capital Management, LLC | Institution | 1.153.496 | 8,04% | US$ 161,85M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 980.758 | 6,84% | US$ 137,61M | 2026-03-31 |
| BVF Partners L.P. | Institution | 960.989 | 6,70% | US$ 134,84M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 882.400 | 6,15% | US$ 123,81M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 714.463 | 4,98% | US$ 100,25M | 2025-09-30 |
| BlackRock, Inc. | Institution | 686.853 | 4,79% | US$ 96,37M | 2026-03-31 |
| Samsara Biocapital, L.P. | Institution | 679.486 | 4,74% | US$ 95,34M | 2024-12-20 |
| Jennison Associates LLC | Institution | 640.611 | 4,47% | US$ 89,88M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 471.202 | 3,29% | US$ 66,11M | 2025-12-31 |
| Frazier Life Sciences Public Fund, L.P. | Institution | 440.575 | 3,07% | US$ 61,82M | 2024-12-13 |
| Federated Hermes, Inc. | Institution | 433.015 | 3,02% | US$ 60,76M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 402.564 | 2,81% | US$ 56,48M | 2026-03-31 |
| Frontier Capital Management Co LLC | Institution | 374.035 | 2,61% | US$ 52,48M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 341.883 | 2,38% | US$ 47,97M | 2025-12-31 |
| Woodline Partners LP | Institution | 317.517 | 2,21% | US$ 44,55M | 2026-03-31 |
| Emerald Advisers, LLC | Institution | 267.320 | 1,86% | US$ 37,51M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 262.835 | 1,83% | US$ 36,88M | 2026-03-31 |
| Artal Group S.A. | Institution | 257.485 | 1,80% | US$ 36,13M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 233.248 | 1,63% | US$ 32,73M | 2026-03-31 |
| FMR LLC | Institution | 215.774 | 1,50% | US$ 30,28M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 206.404 | 1,44% | US$ 28,96M | 2026-03-31 |
| PRIMECAP Management Company | Institution | 195.030 | 1,36% | US$ 27,36M | 2026-03-31 |
| Artisan Partners Limited Partnership | Institution | 193.796 | 1,35% | US$ 27,19M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 186.031 | 1,30% | US$ 26,10M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 179.922 | 1,25% | US$ 25,24M | 2026-03-31 |
| UBS Asset Management AG | Institution | 174.438 | 1,22% | US$ 24,48M | 2026-03-31 |
| First Turn Management, LLC | Institution | 148.093 | 1,03% | US$ 20,78M | 2026-03-31 |
| Dellora Investments LP | Institution | 141.079 | 0,98% | US$ 19,79M | 2024-12-13 |
| OrbiMed Advisors LLC | Institution | 134.600 | 0,94% | US$ 18,89M | 2026-03-31 |
| Frazier Life Sciences Public Overage Fund, L.P. | Institution | 129.905 | 0,91% | US$ 18,23M | 2024-12-13 |
| Dellora Investments Master Fund LP | Institution | 123.034 | 0,86% | US$ 17,26M | 2024-12-13 |
| Balyasny Asset Management L.P. | Institution | 96.726 | 0,67% | US$ 13,57M | 2026-03-31 |
| Millennium Management LLC | Institution | 93.646 | 0,65% | US$ 13,14M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 90.858 | 0,63% | US$ 12,75M | 2026-03-31 |
| Clio Asset Management LLC | Institution | 90.757 | 0,63% | US$ 12,73M | 2026-03-31 |
| Apis Capital Advisors, LLC | Institution | 89.000 | 0,62% | US$ 12,49M | 2026-03-31 |
| Nextbio Capital Management Lp | Institution | 82.686 | 0,58% | US$ 11,60M | 2026-03-31 |