| Tang Capital Management, LLC | Institution | 6.143.132 | 9,92% | US$ 6,82M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.085.017 | 6,60% | US$ 4,53M | 2025-09-03 |
| Tang Capital Partners, LP | Institution | 3.295.127 | 5,32% | US$ 3,66M | 2025-03-03 |
| Citadel Advisors LLC | Institution | 3.226.599 | 5,21% | US$ 3,58M | 2026-03-31 |
| CHI Advisors LLC | Institution | 2.969.199 | 4,80% | US$ 3,30M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.585.126 | 4,17% | US$ 2,87M | 2026-03-31 |
| Tang Capital Partners International, LP | Institution | 2.563.917 | 4,14% | US$ 2,85M | 2025-03-03 |
| Acadian Asset Management LLC | Institution | 2.416.508 | 3,90% | US$ 2,68M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.343.101 | 3,78% | US$ 2,60M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 2.253.138 | 3,64% | US$ 2,50M | 2026-03-31 |
| Monaco Asset Management S.A.M. | Institution | 1.938.747 | 3,13% | US$ 2,15M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.852.842 | 2,99% | US$ 2,06M | 2026-03-31 |
| Prosight Management, LP | Institution | 1.667.600 | 2,69% | US$ 1,85M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.666.830 | 2,69% | US$ 1,85M | 2026-03-31 |
| BML Capital Management, LLC | Institution | 1.546.137 | 2,50% | US$ 1,72M | 2026-03-31 |
| Peapod Lane Capital LLC | Institution | 1.288.578 | 2,08% | US$ 1,43M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.180.518 | 1,91% | US$ 1,31M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.096.430 | 1,77% | US$ 1,22M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.057.954 | 1,71% | US$ 1,17M | 2026-03-31 |
| Marshall Wace LLP | Institution | 995.973 | 1,61% | US$ 1,11M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 891.425 | 1,44% | US$ 989,48k | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 861.823 | 1,39% | US$ 956,62k | 2026-03-31 |
| Redmile Group, LLC | Institution | 772.126 | 1,25% | US$ 857,06k | 2026-03-31 |
| Jacobs Levy Equity Management Inc | Institution | 718.543 | 1,16% | US$ 797,58k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 553.630 | 0,89% | US$ 614,53k | 2026-03-31 |
| Bessemer Investment Management LLC | Institution | 532.079 | 0,86% | US$ 590,61k | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 517.453 | 0,84% | US$ 574,37k | 2026-03-31 |
| Morgan Stanley | Institution | 505.409 | 0,82% | US$ 561,00k | 2026-03-31 |
| XTX Markets Limited | Institution | 500.838 | 0,81% | US$ 555,93k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 498.166 | 0,80% | US$ 552,96k | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 487.000 | 0,79% | US$ 540,57k | 2026-03-31 |
| Centiva Capital, LP | Institution | 432.525 | 0,70% | US$ 480,10k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 417.274 | 0,67% | US$ 463,17k | 2026-03-31 |
| Laurion Capital Management LP | Institution | 412.796 | 0,67% | US$ 458,20k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 402.092 | 0,65% | US$ 446,32k | 2026-03-31 |
| SLGI Asset Management Inc. | Institution | 373.597 | 0,60% | US$ 414,69k | 2025-12-31 |
| Jane Street Group, LLC | Institution | 356.794 | 0,58% | US$ 396,04k | 2026-03-31 |
| Bank of America Corporation | Institution | 352.708 | 0,57% | US$ 391,51k | 2026-03-31 |
| Torno Capital, LLC | Institution | 350.000 | 0,57% | US$ 388,50k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 339.540 | 0,55% | US$ 376,89k | 2026-03-31 |
| SEI Investments Company | Institution | 297.291 | 0,48% | US$ 329,99k | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 281.189 | 0,45% | US$ 312,12k | 2026-03-31 |
| Nano-Cap New Millennium Advisors, Llc | Institution | 275.000 | 0,44% | US$ 305,25k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 253.418 | 0,41% | US$ 281,29k | 2026-03-31 |
| Rangeley Capital, LLC | Institution | 225.000 | 0,36% | US$ 249,75k | 2026-03-31 |