| Tang Capital Management, LLC | Institution | 6.143.132 | 9,92% | US$ 7,13M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.085.017 | 6,60% | US$ 4,74M | 2025-09-03 |
| Tang Capital Partners, LP | Institution | 3.295.127 | 5,32% | US$ 3,82M | 2025-03-03 |
| Citadel Advisors LLC | Institution | 3.226.599 | 5,21% | US$ 3,74M | 2026-03-31 |
| CHI Advisors LLC | Institution | 2.969.199 | 4,80% | US$ 3,44M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 2.585.126 | 4,17% | US$ 3,00M | 2026-03-31 |
| Tang Capital Partners International, LP | Institution | 2.563.917 | 4,14% | US$ 2,97M | 2025-03-03 |
| Acadian Asset Management LLC | Institution | 2.416.508 | 3,90% | US$ 2,80M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.343.101 | 3,78% | US$ 2,72M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 2.253.138 | 3,64% | US$ 2,61M | 2026-03-31 |
| Monaco Asset Management S.A.M. | Institution | 1.938.747 | 3,13% | US$ 2,25M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.852.842 | 2,99% | US$ 2,15M | 2026-03-31 |
| Prosight Management, LP | Institution | 1.667.600 | 2,69% | US$ 1,93M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.666.830 | 2,69% | US$ 1,93M | 2026-03-31 |
| BML Capital Management, LLC | Institution | 1.546.137 | 2,50% | US$ 1,79M | 2026-03-31 |
| Peapod Lane Capital LLC | Institution | 1.288.578 | 2,08% | US$ 1,49M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.180.518 | 1,91% | US$ 1,37M | 2026-03-31 |
| BlackRock, Inc. | Institution | 1.096.430 | 1,77% | US$ 1,27M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.057.954 | 1,71% | US$ 1,23M | 2026-03-31 |
| Marshall Wace LLP | Institution | 995.973 | 1,61% | US$ 1,16M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 891.425 | 1,44% | US$ 1,03M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 861.823 | 1,39% | US$ 999,71k | 2026-03-31 |
| Redmile Group, LLC | Institution | 772.126 | 1,25% | US$ 895,67k | 2026-03-31 |
| Dr. Bernard Coulie | Insider | 763.868 | 1,23% | US$ 886,09k | 2026-01-20 |
| Jacobs Levy Equity Management Inc | Institution | 718.543 | 1,16% | US$ 833,51k | 2026-03-31 |
| Bridgeway Capital Management, LLC | Institution | 553.630 | 0,89% | US$ 642,21k | 2026-03-31 |
| Bessemer Investment Management LLC | Institution | 532.079 | 0,86% | US$ 617,21k | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 517.453 | 0,84% | US$ 600,25k | 2026-03-31 |
| Morgan Stanley | Institution | 505.409 | 0,82% | US$ 586,27k | 2026-03-31 |
| XTX Markets Limited | Institution | 500.838 | 0,81% | US$ 580,97k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 498.166 | 0,80% | US$ 577,87k | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 487.000 | 0,79% | US$ 564,92k | 2026-03-31 |
| Centiva Capital, LP | Institution | 432.525 | 0,70% | US$ 501,73k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 417.274 | 0,67% | US$ 484,04k | 2026-03-31 |
| Laurion Capital Management LP | Institution | 412.796 | 0,67% | US$ 478,84k | 2026-03-31 |
| GSA Capital Partners LLP | Institution | 402.092 | 0,65% | US$ 466,43k | 2026-03-31 |
| SLGI Asset Management Inc. | Institution | 373.597 | 0,60% | US$ 433,37k | 2025-12-31 |
| Jane Street Group, LLC | Institution | 356.794 | 0,58% | US$ 413,88k | 2026-03-31 |
| Bank of America Corporation | Institution | 352.708 | 0,57% | US$ 409,14k | 2026-03-31 |
| Torno Capital, LLC | Institution | 350.000 | 0,57% | US$ 406,00k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 339.540 | 0,55% | US$ 393,87k | 2026-03-31 |
| SEI Investments Company | Institution | 297.291 | 0,48% | US$ 344,86k | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 281.189 | 0,45% | US$ 326,18k | 2026-03-31 |
| Nano-Cap New Millennium Advisors, Llc | Institution | 275.000 | 0,44% | US$ 319,00k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 253.418 | 0,41% | US$ 293,96k | 2026-03-31 |