| FMR LLC | Institution | 7.431.403 | 12,32% | US$ 693,28M | 2026-03-31 |
| VR Management, LLC | Institution | 4.148.428 | 6,88% | US$ 387,01M | 2026-03-31 |
| Fairmount Funds Management LLC | Institution | 3.705.262 | 6,14% | US$ 345,66M | 2026-07-01 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 3.205.865 | 5,32% | US$ 299,08M | 2025-09-30 |
| Viking Global Investors LP | Institution | 2.666.690 | 4,42% | US$ 248,78M | 2026-03-31 |
| Fairmount Healthcare Co-Invest Iii L.P. | Institution | 2.573.308 | 4,27% | US$ 240,06M | 2026-07-01 |
| Paradigm Biocapital Advisors LP | Institution | 2.320.316 | 3,85% | US$ 216,46M | 2026-03-31 |
| RTW Investments, LP | Institution | 2.058.148 | 3,41% | US$ 192,00M | 2026-03-31 |
| RTW Master Fund, Ltd. | Institution | 2.058.147 | 3,41% | US$ 192,00M | 2025-02-15 |
| Deep Track Capital, LP | Institution | 2.034.203 | 3,37% | US$ 189,77M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 1.896.780 | 3,14% | US$ 176,95M | 2025-05-06 |
| State Street Global Advisors, Inc. | Institution | 1.613.461 | 2,68% | US$ 150,52M | 2026-03-31 |
| Viking Global Opportunities Illiquid Investments Sub-Master LP | Institution | 1.600.014 | 2,65% | US$ 149,27M | 2025-09-17 |
| Remedium Capital Partners, LLC | Institution | 1.565.661 | 2,60% | US$ 146,06M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.395.501 | 2,31% | US$ 130,19M | 2026-03-31 |
| Fairmount Healthcare Fund II L.P. | Institution | 1.131.954 | 1,88% | US$ 105,60M | 2026-07-01 |
| Viking Global Opportunities Drawdown (Aggregator) LP | Institution | 1.066.676 | 1,77% | US$ 99,51M | 2025-09-17 |
| Polar Capital Holdings Plc | Institution | 1.047.693 | 1,74% | US$ 97,74M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 1.007.537 | 1,67% | US$ 93,99M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 999.763 | 1,66% | US$ 93,27M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 856.747 | 1,42% | US$ 79,93M | 2025-09-30 |
| Mercer Global Advisors Inc. | Institution | 802.470 | 1,33% | US$ 74,86M | 2026-03-31 |
| Avidity Partners Management, L.P. | Institution | 760.424 | 1,26% | US$ 70,94M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 727.449 | 1,21% | US$ 67,86M | 2026-03-31 |
| Woodline Partners LP | Institution | 574.882 | 0,95% | US$ 53,63M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 533.340 | 0,88% | US$ 49,76M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 507.008 | 0,84% | US$ 47,30M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 499.673 | 0,83% | US$ 46,61M | 2026-03-31 |
| Synergy Asset Management, LLC | Institution | 476.196 | 0,79% | US$ 44,42M | 2026-03-31 |
| SR One Capital Management, LP | Institution | 430.330 | 0,71% | US$ 40,15M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 411.006 | 0,68% | US$ 38,34M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 350.892 | 0,58% | US$ 32,73M | 2026-03-31 |