| Baker Brothers Life Sciences, L.P. | Institution | 16.806.178 | 15,12% | US$ 4,63B | 2026-06-11 |
| Baker Bros. Advisors LP | Institution | 8.881.716 | 7,99% | US$ 2,45B | 2026-06-11 |
| Hhlr Fund, L.P. | Institution | 8.581.841 | 7,72% | US$ 2,36B | 2024-12-31 |
| Capital Research and Management Company | Institution | 7.158.809 | 6,44% | US$ 1,97B | 2026-05-20 |
| Hillhouse Investment Management, Ltd. | Institution | 5.271.893 | 4,74% | US$ 1,45B | 2026-03-31 |
| PRIMECAP Management Company | Institution | 4.975.181 | 4,48% | US$ 1,37B | 2026-03-31 |
| Mr. John Oyler | Insider | 3.868.167 | 3,48% | US$ 1,07B | 2026-06-16 |
| FMR LLC | Institution | 3.670.557 | 3,30% | US$ 1,01B | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.262.684 | 2,94% | US$ 898,35M | 2026-05-31 |
| China Asset Management Co. Ltd. | Institution | 2.965.378 | 2,67% | US$ 816,49M | 2026-05-29 |
| Vanguard Capital Management, LLC | Institution | 2.065.581 | 1,86% | US$ 568,74M | 2026-05-31 |
| Norges Bank Investment Management | Institution | 1.191.543 | 1,07% | US$ 328,08M | 2025-12-31 |
| T. Rowe Price Group, Inc. | Institution | 1.079.889 | 0,97% | US$ 297,34M | 2026-03-31 |
| Hillhouse Fund II, L.P. | Institution | 1.034.120 | 0,93% | US$ 284,73M | 2024-12-31 |
| Citadel Advisors LLC | Institution | 1.032.298 | 0,93% | US$ 284,23M | 2026-03-31 |
| ICBC Credit Suisse Fund Management Co., Ltd | Institution | 989.361 | 0,89% | US$ 272,41M | 2025-06-30 |
| China Universal Asset Management Company Ltd. | Institution | 880.090 | 0,79% | US$ 242,32M | 2026-03-31 |
| Temasek Holdings (Private) Limited | Institution | 862.643 | 0,78% | US$ 237,52M | 2026-03-31 |
| 667, L.P. | Institution | 730.643 | 0,66% | US$ 201,18M | 2026-06-11 |
| Zhong Ou Fund Management Co., Ltd | Institution | 663.936 | 0,60% | US$ 182,81M | 2025-06-30 |
| Baillie Gifford & Co. | Institution | 622.456 | 0,56% | US$ 171,39M | 2026-03-31 |
| UBS Asset Management AG | Institution | 591.559 | 0,53% | US$ 162,88M | 2026-03-31 |
| Bosera Asset Management Co., Ltd. | Institution | 555.119 | 0,50% | US$ 152,85M | 2025-06-30 |
| Yinhua Fund Management Co., Ltd. | Institution | 534.100 | 0,48% | US$ 147,06M | 2025-12-31 |
| Vanguard Fiduciary Trust Company | Institution | 527.424 | 0,47% | US$ 145,22M | 2026-05-31 |
| Fullgoal Fund Management Co. Ltd. | Institution | 521.298 | 0,47% | US$ 143,53M | 2025-06-30 |
| Teachers Insurance and Annuity Association-College Retirement Equities Fund | Institution | 479.299 | 0,43% | US$ 131,97M | 2026-05-29 |
| Artal Group S.A. | Institution | 465.000 | 0,42% | US$ 128,03M | 2026-03-31 |
| CSOP Asset Management Limited | Institution | 430.880 | 0,39% | US$ 118,64M | 2026-05-29 |
| E Fund Management Co., Ltd. | Institution | 409.980 | 0,37% | US$ 112,88M | 2025-06-30 |