| FMR LLC | Institution | 10.386.776 | 11,89% | US$ 110,93M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 8.020.576 | 9,18% | US$ 85,66M | 2026-03-31 |
| Bain Capital Life Sciences Investors, LLC | Institution | 7.473.238 | 8,56% | US$ 79,81M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 7.108.488 | 8,14% | US$ 75,92M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 6.294.992 | 7,21% | US$ 67,23M | 2024-12-31 |
| BlackRock, Inc. | Institution | 5.652.135 | 6,47% | US$ 60,36M | 2026-03-31 |
| BVF Partners L.P. | Institution | 5.295.893 | 6,06% | US$ 56,56M | 2026-03-31 |
| Artal Group S.A. | Institution | 4.461.949 | 5,11% | US$ 47,65M | 2026-04-23 |
| State Street Global Advisors, Inc. | Institution | 3.937.831 | 4,51% | US$ 42,06M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 3.900.000 | 4,46% | US$ 41,65M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 3.898.500 | 4,46% | US$ 41,64M | 2026-04-23 |
| Logos Global Management, L.P. | Institution | 3.208.875 | 3,67% | US$ 34,27M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.083.517 | 3,53% | US$ 32,93M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 2.655.977 | 3,04% | US$ 28,37M | 2025-06-11 |
| RA Capital Management, L.P. | Institution | 2.600.000 | 2,98% | US$ 27,77M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 2.003.966 | 2,29% | US$ 21,40M | 2025-06-11 |
| Jennison Associates LLC | Institution | 1.822.123 | 2,09% | US$ 19,46M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 1.800.000 | 2,06% | US$ 19,22M | 2025-03-18 |
| Polar Capital Holdings Plc | Institution | 1.602.970 | 1,84% | US$ 17,12M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.544.417 | 1,77% | US$ 16,49M | 2026-03-31 |
| Defilade Capital Management, L.P. | Institution | 1.504.536 | 1,72% | US$ 16,07M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.482.030 | 1,70% | US$ 15,83M | 2026-03-31 |
| Lightspeed Ventures, LLC | Institution | 1.355.299 | 1,55% | US$ 14,47M | 2026-03-31 |
| Franklin Resources, Inc. | Institution | 1.217.303 | 1,39% | US$ 13,00M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.182.836 | 1,35% | US$ 12,63M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.169.421 | 1,34% | US$ 12,49M | 2026-03-31 |
| Morgan Stanley | Institution | 1.083.601 | 1,24% | US$ 11,57M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.082.434 | 1,24% | US$ 11,56M | 2026-03-31 |
| Duquesne Family Office LLC | Institution | 986.827 | 1,13% | US$ 10,54M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 905.332 | 1,04% | US$ 9,67M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 859.027 | 0,98% | US$ 9,17M | 2026-03-31 |
| Kingdon Capital Management, L.L.C. | Institution | 855.000 | 0,98% | US$ 9,13M | 2026-03-31 |
| Dr. Cyrus Harmon | Insider | 844.798 | 0,97% | US$ 9,02M | 2026-04-23 |
| First Turn Management, LLC | Institution | 768.662 | 0,88% | US$ 8,21M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 759.513 | 0,87% | US$ 8,11M | 2026-03-31 |
| Squarepoint OPS LLC | Institution | 738.552 | 0,85% | US$ 7,89M | 2026-03-31 |
| Logos Opportunities Fund II LP | Institution | 708.114 | 0,81% | US$ 7,56M | 2025-03-18 |
| Logos Opportunities Fund IV LP | Institution | 700.761 | 0,80% | US$ 7,48M | 2025-03-18 |
| Dr. David Myles | Insider | 700.438 | 0,80% | US$ 7,48M | 2026-01-14 |