| Catalys Pacific Fund, LP | Institution | 7.903.838 | 9,58% | US$ 228,03M | 2026-02-19 |
| Catalys Pacific | Institution | 7.903.838 | 9,58% | US$ 228,03M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 7.692.750 | 9,32% | US$ 221,94M | 2026-03-31 |
| Samsara BioCapital LLC | Institution | 5.871.018 | 7,12% | US$ 169,38M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 5.825.521 | 7,06% | US$ 168,07M | 2026-03-30 |
| Samsara Biocapital, L.P. | Institution | 5.282.783 | 6,40% | US$ 152,41M | 2026-02-19 |
| FMR LLC | Institution | 4.860.813 | 5,89% | US$ 140,23M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.481.582 | 5,43% | US$ 129,29M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 3.359.068 | 4,07% | US$ 96,91M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.935.940 | 3,56% | US$ 84,70M | 2026-03-31 |
| Caligan Partners, LP | Institution | 2.772.654 | 3,36% | US$ 79,99M | 2026-03-31 |
| Biodiscovery 6 FPCI | Institution | 2.765.976 | 3,35% | US$ 79,80M | 2025-06-30 |
| TCG Crossover Fund II, L.P. | Institution | 2.470.265 | 2,99% | US$ 71,27M | 2024-09-30 |
| Vanguard Capital Management, LLC | Institution | 2.454.363 | 2,98% | US$ 70,81M | 2026-03-31 |
| HBM Partners Ltd. | Institution | 2.246.332 | 2,72% | US$ 64,81M | 2024-09-30 |
| Laurion Capital Management LP | Institution | 2.232.040 | 2,71% | US$ 64,39M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 2.052.900 | 2,49% | US$ 59,23M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.911.433 | 2,32% | US$ 55,14M | 2026-03-31 |
| RA Capital Nexus Fund III, L.P. | Institution | 1.867.229 | 2,26% | US$ 53,87M | 2026-03-30 |
| Franklin Resources, Inc. | Institution | 1.780.954 | 2,16% | US$ 51,38M | 2026-03-31 |
| Andera Partners | Institution | 1.591.917 | 1,93% | US$ 45,93M | 2026-03-31 |
| SR One Capital Management, LP | Institution | 1.563.966 | 1,90% | US$ 45,12M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 1.538.662 | 1,87% | US$ 44,39M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 1.500.749 | 1,82% | US$ 43,30M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 1.343.313 | 1,63% | US$ 38,75M | 2026-03-31 |
| Sphera Funds Management Ltd | Institution | 1.339.971 | 1,62% | US$ 38,66M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.301.135 | 1,58% | US$ 37,54M | 2026-03-31 |
| Jennison Associates LLC | Institution | 1.266.174 | 1,53% | US$ 36,53M | 2026-03-31 |
| Armistice Capital LLC | Institution | 1.176.000 | 1,43% | US$ 33,93M | 2026-03-31 |
| Bank of America Corporation | Institution | 1.034.832 | 1,25% | US$ 29,85M | 2026-03-31 |
| Pictet Asset Management Limited | Institution | 1.034.438 | 1,25% | US$ 29,84M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 1.001.728 | 1,21% | US$ 28,90M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 975.961 | 1,18% | US$ 28,16M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 914.728 | 1,11% | US$ 26,39M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 895.481 | 1,09% | US$ 25,83M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 887.192 | 1,08% | US$ 25,60M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 884.107 | 1,07% | US$ 25,51M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 801.904 | 0,97% | US$ 23,13M | 2026-03-31 |
| Integral Health Asset Management, LLC | Institution | 750.000 | 0,91% | US$ 21,64M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 750.000 | 0,91% | US$ 21,64M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 706.658 | 0,86% | US$ 20,39M | 2026-03-31 |