| Third Rock Ventures, LLC | Institution | 5.424.758 | 9,80% | US$ 175,87M | 2026-03-31 |
| Frazier Life Sciences Management, LP | Institution | 4.567.274 | 8,25% | US$ 148,07M | 2026-03-31 |
| Third Rock Ventures IV, LP | Institution | 4.473.958 | 8,08% | US$ 145,05M | 2025-12-31 |
| Frazier Life Sciences Public Fund, L.P. | Institution | 4.342.266 | 7,85% | US$ 140,78M | 2025-12-31 |
| Arch Venture Partners, L.P. | Institution | 4.120.053 | 7,44% | US$ 133,57M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 3.948.910 | 7,14% | US$ 128,02M | 2025-09-30 |
| Deep Track Capital, LP | Institution | 3.477.562 | 6,28% | US$ 112,74M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.206.472 | 5,79% | US$ 103,95M | 2025-09-30 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 2.799.705 | 5,06% | US$ 90,77M | 2025-09-30 |
| Paradigm Biocapital Advisors LP | Institution | 2.744.399 | 4,96% | US$ 88,97M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 2.688.520 | 4,86% | US$ 87,16M | 2026-03-25 |
| BlackRock, Inc. | Institution | 2.570.425 | 4,64% | US$ 83,33M | 2026-03-31 |
| Matrix Capital Management Master Fund, L.P. | Institution | 2.486.184 | 4,49% | US$ 80,60M | 2025-03-31 |
| Arch Venture Fund X Overage, L.P. | Institution | 2.170.123 | 3,92% | US$ 70,36M | 2025-02-28 |
| Arch Venture Fund X, L.P. | Institution | 1.949.930 | 3,52% | US$ 63,22M | 2025-02-28 |
| Andreessen Horowitz LLC | Institution | 1.702.225 | 3,08% | US$ 55,19M | 2026-03-31 |
| VR Management, LLC | Institution | 1.602.034 | 2,89% | US$ 51,94M | 2026-03-31 |
| GV Management Company, LLC | Institution | 1.388.583 | 2,51% | US$ 45,02M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 1.235.000 | 2,23% | US$ 40,04M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 1.178.000 | 2,13% | US$ 38,19M | 2026-03-31 |
| General Catalyst Group Management, LLC | Institution | 1.035.910 | 1,87% | US$ 33,58M | 2026-03-31 |
| Frazier Life Sciences Public Overage Fund, L.P. | Institution | 989.351 | 1,79% | US$ 32,07M | 2025-09-30 |
| Third Rock Ventures V, LP | Institution | 950.800 | 1,72% | US$ 30,82M | 2025-12-31 |
| FMR LLC | Institution | 862.915 | 1,56% | US$ 27,98M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 775.714 | 1,40% | US$ 25,15M | 2026-03-31 |
| ArrowMark Colorado Holdings, LLC | Institution | 767.383 | 1,39% | US$ 24,88M | 2026-03-31 |
| Casdin Capital, LLC | Institution | 758.857 | 1,37% | US$ 24,60M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 750.000 | 1,36% | US$ 24,32M | 2026-03-31 |
| Woodline Partners LP | Institution | 650.229 | 1,17% | US$ 21,08M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 636.162 | 1,15% | US$ 20,62M | 2026-03-31 |
| Caligan Partners, LP | Institution | 614.962 | 1,11% | US$ 19,94M | 2026-03-31 |
| Foresite Capital Fund IV, L.P. | Institution | 522.657 | 0,94% | US$ 16,94M | 2025-09-30 |
| Bessemer Investment Management LLC | Institution | 481.790 | 0,87% | US$ 15,62M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 461.151 | 0,83% | US$ 14,95M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 378.999 | 0,68% | US$ 12,29M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 373.000 | 0,67% | US$ 12,09M | 2026-03-31 |
| Hillhouse Investment Management, Ltd. | Institution | 366.028 | 0,66% | US$ 11,87M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 324.041 | 0,59% | US$ 10,51M | 2025-12-31 |
| Dr. Jason Coloma | Insider | 310.508 | 0,56% | US$ 10,07M | 2026-07-01 |
| City Hill Ventures, LLC | Institution | 307.956 | 0,56% | US$ 9,98M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 284.476 | 0,51% | US$ 9,22M | 2026-03-31 |
| Washington University Investment Management Company | Institution | 280.802 | 0,51% | US$ 9,10M | 2026-03-31 |
| Candriam, Société En Commandite Par Actions | Institution | 278.167 | 0,50% | US$ 9,02M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 257.500 | 0,47% | US$ 8,35M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 257.353 | 0,47% | US$ 8,34M | 2026-03-31 |