| Janus Henderson Group plc | Institution | 33.094.330 | 11,23% | US$ 28,87M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 21.785.166 | 7,39% | US$ 19,01M | 2025-11-19 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 21.576.145 | 7,32% | US$ 18,82M | 2025-09-30 |
| Perceptive Advisors LLC | Institution | 20.859.303 | 7,08% | US$ 18,20M | 2026-03-31 |
| BVF Partners L.P. | Institution | 19.525.000 | 6,63% | US$ 17,03M | 2026-03-31 |
| Maverick Capital, Ltd. | Institution | 18.970.913 | 6,44% | US$ 16,55M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 16.730.467 | 5,68% | US$ 14,60M | 2025-08-26 |
| Mithril Capital Management LLC | Institution | 11.241.580 | 3,82% | US$ 9,81M | 2025-09-30 |
| Saturn V Capital Management LP | Institution | 10.949.084 | 3,72% | US$ 9,55M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 10.074.326 | 3,42% | US$ 8,79M | 2026-03-31 |
| M28 Capital Management LP | Institution | 9.248.250 | 3,14% | US$ 8,07M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 9.071.995 | 3,08% | US$ 7,91M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 8.545.920 | 2,90% | US$ 7,46M | 2025-10-22 |
| Driehaus Capital Management LLC | Institution | 8.436.894 | 2,86% | US$ 7,36M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 7.708.727 | 2,62% | US$ 6,73M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 6.935.648 | 2,35% | US$ 6,05M | 2026-03-31 |
| Polaris Growth Management, L.L.C. | Institution | 6.797.997 | 2,31% | US$ 5,93M | 2025-08-22 |
| Biotechnology Value Fund II, L.P. | Institution | 6.211.464 | 2,11% | US$ 5,42M | 2025-10-22 |
| Soleus Capital Master Fund, L.P. | Institution | 6.028.567 | 2,05% | US$ 5,26M | 2025-12-31 |
| BlackRock, Inc. | Institution | 4.281.790 | 1,45% | US$ 3,74M | 2026-03-31 |
| Artal Group S.A. | Institution | 4.000.000 | 1,36% | US$ 3,49M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 3.822.427 | 1,30% | US$ 3,33M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 3.661.480 | 1,24% | US$ 3,19M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 3.515.644 | 1,19% | US$ 3,07M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.511.581 | 1,19% | US$ 3,06M | 2026-03-31 |
| Morgan Stanley | Institution | 3.387.810 | 1,15% | US$ 2,96M | 2026-03-31 |
| Polaris Venture Partners V, L.P. | Institution | 3.120.194 | 1,06% | US$ 2,72M | 2025-08-22 |
| Qube Research & Technologies Ltd | Institution | 2.687.195 | 0,91% | US$ 2,34M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 2.656.570 | 0,90% | US$ 2,32M | 2026-03-31 |
| Redmile Group, LLC | Institution | 2.648.659 | 0,90% | US$ 2,31M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 2.580.198 | 0,88% | US$ 2,25M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 2.515.000 | 0,85% | US$ 2,19M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.468.927 | 0,84% | US$ 2,15M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 2.276.349 | 0,77% | US$ 1,99M | 2026-03-31 |
| Ensign Peak Advisors, Inc. | Institution | 2.019.207 | 0,69% | US$ 1,76M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 1.969.659 | 0,67% | US$ 1,72M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.903.713 | 0,65% | US$ 1,66M | 2026-03-31 |
| StemPoint Capital LP | Institution | 1.874.546 | 0,64% | US$ 1,64M | 2026-03-31 |
| Soleus Capital LLC | Institution | 1.680.160 | 0,57% | US$ 1,47M | 2025-12-31 |
| Soleus Private Equity Fund III LP | Institution | 1.680.160 | 0,57% | US$ 1,47M | 2025-12-31 |
| Citadel Advisors LLC | Institution | 1.589.575 | 0,54% | US$ 1,39M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 1.500.000 | 0,51% | US$ 1,31M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.318.665 | 0,45% | US$ 1,15M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.226.165 | 0,42% | US$ 1,07M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1.218.214 | 0,41% | US$ 1,06M | 2026-03-31 |