| Caligan Partners, LP | Institution | 6.075.028 | 8,51% | US$ 28,19M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 6.029.775 | 8,44% | US$ 27,98M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 6.029.775 | 8,44% | US$ 27,98M | 2026-03-31 |
| Atlas Diversified Master Fund, Ltd. | Institution | 5.110.373 | 7,16% | US$ 23,71M | 2026-03-31 |
| Foundation Fighting Blindness | Institution | 3.792.171 | 5,31% | US$ 17,60M | 2026-05-18 |
| Bios Equity Partners LP | Institution | 3.683.429 | 5,16% | US$ 17,09M | 2026-05-12 |
| BIOS Fund III QP, LP | Institution | 2.801.953 | 3,92% | US$ 13,00M | 2026-05-12 |
| Balyasny Asset Management L.P. | Institution | 2.718.029 | 3,81% | US$ 12,61M | 2026-03-31 |
| Millennium Management LLC | Institution | 2.630.432 | 3,68% | US$ 12,21M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.449.987 | 3,43% | US$ 11,37M | 2026-03-31 |
| Marshall Wace LLP | Institution | 2.313.380 | 3,24% | US$ 10,73M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 2.250.000 | 3,15% | US$ 10,44M | 2026-03-31 |
| Mr. Cameron Gallagher | Insider | 1.974.430 | 2,77% | US$ 9,16M | 2026-04-20 |
| ADAR1 Capital Management, LLC | Institution | 1.849.004 | 2,59% | US$ 8,58M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.835.842 | 2,57% | US$ 8,52M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 1.835.842 | 2,57% | US$ 8,52M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.681.330 | 2,35% | US$ 7,80M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.354.030 | 1,90% | US$ 6,28M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 1.189.113 | 1,67% | US$ 5,52M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 1.120.000 | 1,57% | US$ 5,20M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 1.000.000 | 1,40% | US$ 4,64M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 823.383 | 1,15% | US$ 3,82M | 2026-03-31 |
| Dr. George Magrath | Insider | 819.193 | 1,15% | US$ 3,80M | 2026-03-16 |
| Bleichroeder LP | Institution | 736.842 | 1,03% | US$ 3,42M | 2026-03-31 |
| Dr. Benjamin Yerxa | Insider | 711.535 | 1,00% | US$ 3,30M | 2026-04-23 |
| Mr. Robert Gagnon | Insider | 592.158 | 0,83% | US$ 2,75M | 2026-04-23 |
| Mink Brook Asset Management LLC | Institution | 590.552 | 0,83% | US$ 2,74M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 538.347 | 0,75% | US$ 2,50M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 500.000 | 0,70% | US$ 2,32M | 2026-03-31 |
| BIOS Fund III NT, LP | Institution | 450.811 | 0,63% | US$ 2,09M | 2026-05-12 |
| BIOS Fund III, LP | Institution | 430.665 | 0,60% | US$ 2,00M | 2026-05-12 |
| Columbia Management Investment Advisers, LLC | Institution | 388.491 | 0,54% | US$ 1,80M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 326.809 | 0,46% | US$ 1,52M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 324.340 | 0,45% | US$ 1,50M | 2026-03-31 |
| Mr. Richard Rodgers | Insider | 318.655 | 0,45% | US$ 1,48M | 2026-04-20 |
| Mr. Sean Ainsworth | Insider | 297.325 | 0,42% | US$ 1,38M | 2026-04-20 |
| Dr. James S. Manuso | Insider | 292.951 | 0,41% | US$ 1,36M | 2026-04-20 |
| Vanguard Fiduciary Trust Company | Institution | 281.801 | 0,39% | US$ 1,31M | 2026-03-31 |
| UBS Asset Management AG | Institution | 257.649 | 0,36% | US$ 1,20M | 2026-03-31 |
| Dr. Jean Bennett | Insider | 234.652 | 0,33% | US$ 1,09M | 2026-04-20 |
| Ms. Susan Benton | Insider | 219.527 | 0,31% | US$ 1,02M | 2026-04-20 |
| State Street Global Advisors, Inc. | Institution | 199.953 | 0,28% | US$ 927,78k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 158.103 | 0,22% | US$ 733,60k | 2026-03-31 |
| BlackRock, Inc. | Institution | 147.740 | 0,21% | US$ 685,51k | 2026-03-31 |
| Voleon Capital Management LP | Institution | 143.796 | 0,20% | US$ 667,21k | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 134.242 | 0,19% | US$ 622,88k | 2026-03-31 |