| Caligan Partners, LP | Institution | 6.075.028 | 7,46% | US$ 22,60M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 6.029.775 | 7,41% | US$ 22,43M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 6.029.775 | 7,41% | US$ 22,43M | 2026-03-31 |
| Atlas Diversified Master Fund, Ltd. | Institution | 5.110.373 | 6,28% | US$ 19,01M | 2026-03-31 |
| Foundation Fighting Blindness | Institution | 3.792.171 | 4,66% | US$ 14,11M | 2026-05-18 |
| Bios Equity Partners LP | Institution | 3.683.429 | 4,53% | US$ 13,70M | 2026-05-12 |
| BIOS Fund III QP, LP | Institution | 2.801.953 | 3,44% | US$ 10,42M | 2026-05-12 |
| Balyasny Asset Management L.P. | Institution | 2.718.029 | 3,34% | US$ 10,11M | 2026-03-31 |
| Millennium Management LLC | Institution | 2.630.432 | 3,23% | US$ 9,79M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.449.987 | 3,01% | US$ 9,11M | 2026-03-31 |
| Marshall Wace LLP | Institution | 2.313.380 | 2,84% | US$ 8,61M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 2.250.000 | 2,76% | US$ 8,37M | 2026-03-31 |
| Mr. Cameron Gallagher | Insider | 1.974.430 | 2,43% | US$ 7,34M | 2026-04-20 |
| ADAR1 Capital Management, LLC | Institution | 1.849.004 | 2,27% | US$ 6,88M | 2026-03-31 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 1.835.842 | 2,26% | US$ 6,83M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.835.842 | 2,26% | US$ 6,83M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 1.681.330 | 2,07% | US$ 6,25M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.354.030 | 1,66% | US$ 5,04M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 1.189.113 | 1,46% | US$ 4,42M | 2026-03-31 |
| Opaleye Management Inc. | Institution | 1.120.000 | 1,38% | US$ 4,17M | 2026-03-31 |
| Farallon Capital Management, L.L.C. | Institution | 1.000.000 | 1,23% | US$ 3,72M | 2026-03-31 |
| Dr. George Magrath | Insider | 839.910 | 1,03% | US$ 3,12M | 2026-04-23 |
| Susquehanna International Group, LLP | Institution | 823.383 | 1,01% | US$ 3,06M | 2026-03-31 |
| Bleichroeder LP | Institution | 736.842 | 0,91% | US$ 2,74M | 2026-03-31 |
| Dr. Benjamin Yerxa | Insider | 711.535 | 0,87% | US$ 2,65M | 2026-04-23 |
| Mr. Robert Gagnon | Insider | 592.158 | 0,73% | US$ 2,20M | 2026-04-23 |
| Mink Brook Asset Management LLC | Institution | 590.552 | 0,73% | US$ 2,20M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 538.347 | 0,66% | US$ 2,00M | 2026-03-31 |
| Trails Edge Capital Partners, LP | Institution | 500.000 | 0,61% | US$ 1,86M | 2026-03-31 |
| BIOS Fund III NT, LP | Institution | 450.811 | 0,55% | US$ 1,68M | 2026-05-12 |
| BIOS Fund III, LP | Institution | 430.665 | 0,53% | US$ 1,60M | 2026-05-12 |
| Columbia Management Investment Advisers, LLC | Institution | 388.491 | 0,48% | US$ 1,45M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 326.809 | 0,40% | US$ 1,22M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 324.340 | 0,40% | US$ 1,21M | 2026-03-31 |
| Mr. Richard Rodgers | Insider | 318.655 | 0,39% | US$ 1,19M | 2026-04-20 |
| Mr. Sean Ainsworth | Insider | 297.325 | 0,37% | US$ 1,11M | 2026-04-20 |
| Dr. James S. Manuso | Insider | 292.951 | 0,36% | US$ 1,09M | 2026-04-20 |
| Vanguard Fiduciary Trust Company | Institution | 281.801 | 0,35% | US$ 1,05M | 2026-03-31 |
| UBS Asset Management AG | Institution | 257.649 | 0,32% | US$ 958,45k | 2026-03-31 |
| Dr. Jean Bennett | Insider | 234.652 | 0,29% | US$ 872,91k | 2026-04-20 |
| Ms. Susan Benton | Insider | 219.527 | 0,27% | US$ 816,64k | 2026-04-20 |
| State Street Global Advisors, Inc. | Institution | 199.953 | 0,25% | US$ 743,83k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 158.103 | 0,19% | US$ 588,14k | 2026-03-31 |
| BlackRock, Inc. | Institution | 147.740 | 0,18% | US$ 549,59k | 2026-03-31 |
| Voleon Capital Management LP | Institution | 143.796 | 0,18% | US$ 534,92k | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 134.242 | 0,16% | US$ 499,38k | 2026-03-31 |