| T. Rowe Price Group, Inc. | Institution | 19.222.874 | 16,97% | US$ 413,10M | 2026-03-31 |
| FMR LLC | Institution | 16.969.954 | 14,98% | US$ 364,68M | 2026-03-31 |
| BlackRock, Inc. | Institution | 8.168.674 | 7,21% | US$ 175,54M | 2026-03-31 |
| Redmile Group, LLC | Institution | 5.558.885 | 4,91% | US$ 119,46M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 5.399.901 | 4,77% | US$ 116,04M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 4.887.110 | 4,32% | US$ 105,02M | 2025-01-31 |
| PRIMECAP Management Company | Institution | 4.788.231 | 4,23% | US$ 102,90M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 4.731.977 | 4,18% | US$ 101,69M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 4.429.697 | 3,91% | US$ 95,19M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 4.099.901 | 3,62% | US$ 88,11M | 2026-03-31 |
| Redmile Biopharma Investments III, L.P. | Institution | 3.879.415 | 3,43% | US$ 83,37M | 2025-03-31 |
| Ecor1 Capital Fund Qualified, L.P. | Institution | 3.847.477 | 3,40% | US$ 82,68M | 2025-03-31 |
| Morgan Stanley | Institution | 2.804.695 | 2,48% | US$ 60,27M | 2026-03-31 |
| JP Morgan Asset Management | Institution | 2.690.240 | 2,38% | US$ 57,81M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.560.664 | 2,26% | US$ 55,03M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 1.850.278 | 1,63% | US$ 39,76M | 2026-03-31 |
| Sofinnova Investments, Inc. | Institution | 1.701.904 | 1,50% | US$ 36,57M | 2026-03-31 |
| Woodline Partners LP | Institution | 1.575.398 | 1,39% | US$ 33,86M | 2026-03-31 |
| Marshall Wace LLP | Institution | 1.480.788 | 1,31% | US$ 31,82M | 2026-03-31 |
| Principal Global Investors, LLC | Institution | 1.376.867 | 1,22% | US$ 29,59M | 2026-03-31 |
| Readystate Asset Management LP | Institution | 1.301.862 | 1,15% | US$ 27,98M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 1.160.715 | 1,02% | US$ 24,94M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.006.975 | 0,89% | US$ 21,64M | 2026-03-31 |
| BNPP Asset Management Holding | Institution | 918.213 | 0,81% | US$ 19,73M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 899.146 | 0,79% | US$ 19,32M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 882.457 | 0,78% | US$ 18,96M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 851.789 | 0,75% | US$ 18,30M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 849.479 | 0,75% | US$ 18,26M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 808.019 | 0,71% | US$ 17,36M | 2026-03-31 |
| Bank of America Corporation | Institution | 781.607 | 0,69% | US$ 16,80M | 2026-03-31 |
| Pivotal BioVenture Partners LLC | Institution | 732.512 | 0,65% | US$ 15,74M | 2026-03-31 |