| Wellington Management Group LLP | Institution | 7.260.287 | 10,22% | US$ 378,41M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 7.090.107 | 9,98% | US$ 369,54M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 7.026.070 | 9,89% | US$ 366,20M | 2025-09-30 |
| Avoro Capital Advisors LLC | Institution | 6.555.555 | 9,22% | US$ 341,68M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 5.354.981 | 7,54% | US$ 279,10M | 2026-03-31 |
| BVF Partners L.P. | Institution | 3.459.358 | 4,87% | US$ 180,30M | 2026-03-31 |
| Morgan Stanley | Institution | 2.236.275 | 3,15% | US$ 116,55M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 2.000.696 | 2,82% | US$ 104,28M | 2026-03-31 |
| Principal Global Investors, LLC | Institution | 1.753.764 | 2,47% | US$ 91,41M | 2026-03-31 |
| Biotechnology Value Fund L.P. | Institution | 1.662.117 | 2,34% | US$ 86,63M | 2025-08-18 |
| Driehaus Capital Management LLC | Institution | 1.577.356 | 2,22% | US$ 82,21M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 1.475.403 | 2,08% | US$ 76,90M | 2026-03-31 |
| American Century Investment Management Inc | Institution | 1.438.031 | 2,02% | US$ 74,95M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 1.432.529 | 2,02% | US$ 74,66M | 2026-03-31 |
| Artal Group S.A. | Institution | 1.328.698 | 1,87% | US$ 69,25M | 2026-03-31 |
| Biotechnology Value Fund II, L.P. | Institution | 1.300.674 | 1,83% | US$ 67,79M | 2025-08-18 |
| Casdin Capital, LLC | Institution | 1.175.000 | 1,65% | US$ 61,24M | 2026-03-31 |
| Capitolis Advisors LLC | Institution | 1.151.300 | 1,62% | US$ 60,01M | 2026-03-31 |
| Mr. Jun Yoon | Insider | 894.610 | 1,26% | US$ 46,63M | 2026-03-19 |
| Deerfield Management Company, L.P. | Institution | 767.993 | 1,08% | US$ 40,03M | 2026-03-31 |
| Pacific Heights Asset Management, LLC | Institution | 750.000 | 1,06% | US$ 39,09M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 640.217 | 0,90% | US$ 33,37M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 577.223 | 0,81% | US$ 30,08M | 2026-04-30 |
| Paradigm Biocapital Advisors LP | Institution | 545.287 | 0,77% | US$ 28,42M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 500.000 | 0,70% | US$ 26,06M | 2026-03-31 |
| Healthcare of Ontario Pension Plan Trust Fund | Institution | 467.800 | 0,66% | US$ 24,38M | 2026-03-31 |
| Hartford Funds Management Company, LLC | Institution | 360.299 | 0,51% | US$ 18,78M | 2026-05-31 |
| Impresa Management LLC | Institution | 324.734 | 0,46% | US$ 16,93M | 2026-03-31 |