| Redmile Group, LLC | Institution | 12.872.946 | 11,04% | US$ 28,45M | 2026-04-20 |
| ARK Investment Management LLC | Institution | 10.312.167 | 8,85% | US$ 22,79M | 2026-03-31 |
| BlackRock, Inc. | Institution | 10.068.614 | 8,64% | US$ 22,25M | 2026-03-31 |
| Boxer Capital Management, LLC | Institution | 4.960.910 | 4,26% | US$ 10,96M | 2024-10-10 |
| Vanguard Capital Management, LLC | Institution | 4.192.063 | 3,60% | US$ 9,26M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 4.134.585 | 3,55% | US$ 9,14M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 4.120.200 | 3,53% | US$ 9,11M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 3.466.786 | 2,97% | US$ 7,66M | 2026-03-31 |
| Johnson & Johnson Innovation - JJDC, Inc. | Institution | 3.379.064 | 2,90% | US$ 7,47M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 2.974.683 | 2,55% | US$ 6,57M | 2026-03-31 |
| AQR Capital Management, LLC | Institution | 2.923.910 | 2,51% | US$ 6,46M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 2.590.429 | 2,22% | US$ 5,72M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.263.173 | 1,94% | US$ 5,00M | 2026-03-31 |
| Redmile Biopharma Investments I | Institution | 1.931.216 | 1,66% | US$ 4,27M | 2026-04-20 |
| UBS Asset Management AG | Institution | 1.822.530 | 1,56% | US$ 4,03M | 2026-03-31 |
| Redmile Strategic Long Only Trading Sub, Ltd. | Institution | 1.253.227 | 1,08% | US$ 2,77M | 2026-04-20 |
| Tang Capital Management, LLC | Institution | 1.167.773 | 1,00% | US$ 2,58M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.026.838 | 0,88% | US$ 2,27M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 942.926 | 0,81% | US$ 2,08M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 883.790 | 0,76% | US$ 1,95M | 2026-03-31 |
| Irenic Capital Management LP | Institution | 878.055 | 0,75% | US$ 1,94M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 811.920 | 0,70% | US$ 1,79M | 2026-03-31 |
| Monaco Asset Management S.A.M. | Institution | 810.000 | 0,69% | US$ 1,79M | 2026-03-31 |
| Bruce & Co Inc | Institution | 789.188 | 0,68% | US$ 1,74M | 2026-03-31 |
| Morgan Stanley | Institution | 765.306 | 0,66% | US$ 1,69M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 756.273 | 0,65% | US$ 1,67M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 653.761 | 0,56% | US$ 1,44M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 646.979 | 0,56% | US$ 1,43M | 2026-03-31 |
| Dr. William Rastetter | Insider | 642.424 | 0,55% | US$ 1,42M | 2026-05-05 |
| Ms. Cindy Tahl | Insider | 628.155 | 0,54% | US$ 1,39M | 2026-05-20 |
| Dafna Capital Management, LLC | Institution | 550.000 | 0,47% | US$ 1,22M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 469.785 | 0,40% | US$ 1,04M | 2026-03-31 |
| Numeric Investors LLC | Institution | 430.073 | 0,37% | US$ 950,46k | 2026-03-31 |
| Privium Fund Management BV | Institution | 414.311 | 0,36% | US$ 915,63k | 2026-03-31 |
| XTX Markets Limited | Institution | 389.169 | 0,33% | US$ 860,06k | 2026-03-31 |
| Redmile Capital Offshore Fund II, Ltd | Institution | 353.233 | 0,30% | US$ 780,64k | 2026-04-20 |
| Invesco Capital Management LLC | Institution | 347.310 | 0,30% | US$ 767,56k | 2026-03-31 |