| Frazier Life Sciences Management, LP | Institution | 24.675.188 | 7,93% | US$ 451,31M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 23.074.986 | 7,42% | US$ 422,04M | 2026-03-31 |
| VR Management, LLC | Institution | 16.216.216 | 5,21% | US$ 296,59M | 2026-04-15 |
| RTW Investments, LP | Institution | 16.157.175 | 5,20% | US$ 295,51M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 13.378.378 | 4,30% | US$ 244,69M | 2026-04-15 |
| Paradigm BioCapital International Fund Ltd. | Institution | 13.377.027 | 4,30% | US$ 244,67M | 2026-01-07 |
| Vivo Capital, LLC | Institution | 12.151.480 | 3,91% | US$ 222,25M | 2026-03-31 |
| Artal Group S.A. | Institution | 11.244.246 | 3,62% | US$ 205,66M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 11.150.000 | 3,59% | US$ 203,93M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 10.392.702 | 3,34% | US$ 190,08M | 2026-03-31 |
| Arch Venture Partners, L.P. | Institution | 7.091.557 | 2,28% | US$ 129,70M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 5.800.000 | 1,87% | US$ 106,08M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 5.350.000 | 1,72% | US$ 97,85M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 5.143.985 | 1,65% | US$ 94,08M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 3.485.971 | 1,12% | US$ 63,76M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 3.434.967 | 1,10% | US$ 62,83M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 3.254.019 | 1,05% | US$ 59,52M | 2026-03-31 |
| Commodore Capital LP | Institution | 3.175.000 | 1,02% | US$ 58,07M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 2.945.497 | 0,95% | US$ 53,87M | 2026-03-31 |
| Andreessen Horowitz LLC | Institution | 2.862.500 | 0,92% | US$ 52,36M | 2026-03-31 |
| Woodline Partners LP | Institution | 2.831.538 | 0,91% | US$ 51,79M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 2.580.000 | 0,83% | US$ 47,19M | 2026-04-15 |
| Adage Capital Management, L.P. | Institution | 2.100.000 | 0,68% | US$ 38,41M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 1.851.812 | 0,60% | US$ 33,87M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 1.398.869 | 0,45% | US$ 25,59M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1.219.534 | 0,39% | US$ 22,31M | 2026-03-31 |
| Rock Springs Capital Management LP | Institution | 1.103.469 | 0,35% | US$ 20,18M | 2026-03-31 |
| EcoR1 Capital, LLC | Institution | 900.000 | 0,29% | US$ 16,46M | 2026-03-31 |
| First Turn Management, LLC | Institution | 867.639 | 0,28% | US$ 15,87M | 2026-03-31 |
| Holocene Advisors, LP | Institution | 760.722 | 0,24% | US$ 13,91M | 2026-03-31 |