| Dr. Jonathan Lim | Insider | 32.355.576 | 10,40% | US$ 426,45M | 2026-04-15 |
| Frazier Life Sciences Management, LP | Institution | 24.675.188 | 7,93% | US$ 325,22M | 2026-03-31 |
| T. Rowe Price Group, Inc. | Institution | 23.074.986 | 7,42% | US$ 304,13M | 2026-03-31 |
| BlackRock, Inc. | Institution | 20.151.406 | 6,48% | US$ 265,60M | 2026-03-31 |
| VR Management, LLC | Institution | 16.216.216 | 5,21% | US$ 213,73M | 2026-04-15 |
| RTW Investments, LP | Institution | 16.157.175 | 5,20% | US$ 212,95M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 13.378.378 | 4,30% | US$ 176,33M | 2026-04-15 |
| Paradigm BioCapital International Fund Ltd. | Institution | 13.377.027 | 4,30% | US$ 176,31M | 2026-01-07 |
| Novartis AG | Institution | 12.307.692 | 3,96% | US$ 162,22M | 2024-12-31 |
| Vivo Capital, LLC | Institution | 12.151.480 | 3,91% | US$ 160,16M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 11.249.738 | 3,62% | US$ 148,27M | 2026-03-31 |
| Artal Group S.A. | Institution | 11.244.246 | 3,62% | US$ 148,20M | 2026-03-31 |
| Logos Global Management, L.P. | Institution | 11.150.000 | 3,59% | US$ 146,96M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 10.392.702 | 3,34% | US$ 136,98M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 9.300.084 | 2,99% | US$ 122,58M | 2026-03-31 |
| Arch Venture Partners, L.P. | Institution | 7.091.557 | 2,28% | US$ 93,47M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 5.996.149 | 1,93% | US$ 79,03M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 5.800.000 | 1,87% | US$ 76,44M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 5.350.000 | 1,72% | US$ 70,51M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 5.143.985 | 1,65% | US$ 67,80M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 3.710.966 | 1,19% | US$ 48,91M | 2026-03-31 |
| 5AM Venture Management, LLC | Institution | 3.485.971 | 1,12% | US$ 45,95M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 3.434.967 | 1,10% | US$ 45,27M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 3.254.019 | 1,05% | US$ 42,89M | 2026-03-31 |
| Commodore Capital LP | Institution | 3.175.000 | 1,02% | US$ 41,85M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 2.945.497 | 0,95% | US$ 38,82M | 2026-03-31 |
| Bank of America Corporation | Institution | 2.889.329 | 0,93% | US$ 38,08M | 2026-03-31 |
| Andreessen Horowitz LLC | Institution | 2.862.500 | 0,92% | US$ 37,73M | 2026-03-31 |
| Woodline Partners LP | Institution | 2.831.538 | 0,91% | US$ 37,32M | 2026-03-31 |
| AllianceBernstein L.P. | Institution | 2.644.920 | 0,85% | US$ 34,86M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 2.580.000 | 0,83% | US$ 34,00M | 2026-04-15 |
| UBS Asset Management AG | Institution | 2.107.587 | 0,68% | US$ 27,78M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 2.100.000 | 0,68% | US$ 27,68M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 1.898.224 | 0,61% | US$ 25,02M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 1.851.812 | 0,60% | US$ 24,41M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 1.786.389 | 0,57% | US$ 23,54M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 1.773.757 | 0,57% | US$ 23,38M | 2026-03-31 |
| Northern Trust Global Investments | Institution | 1.701.623 | 0,55% | US$ 22,43M | 2026-03-31 |
| Victory Capital Management Inc. | Institution | 1.654.497 | 0,53% | US$ 21,81M | 2026-03-31 |
| Goldman Sachs Asset Management, L.P. | Institution | 1.621.167 | 0,52% | US$ 21,37M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 1.537.915 | 0,49% | US$ 20,27M | 2026-03-31 |