| Janus Henderson Group plc | Institution | 6.494.571 | 10,27% | US$ 19,16M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 5.329.416 | 8,43% | US$ 15,72M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 5.329.416 | 8,43% | US$ 15,72M | 2025-09-30 |
| Decheng Capital LLC | Institution | 4.447.308 | 7,03% | US$ 13,12M | 2026-03-31 |
| ADAR1 Partners, LP | Institution | 4.327.145 | 6,84% | US$ 12,77M | 2025-09-30 |
| ADAR1 Capital Management, LLC | Institution | 3.726.659 | 5,89% | US$ 10,99M | 2026-03-31 |
| Woodline Partners LP | Institution | 3.500.901 | 5,54% | US$ 10,33M | 2026-03-31 |
| Aberdeen Group Plc | Institution | 3.352.837 | 5,30% | US$ 9,89M | 2026-04-01 |
| RA Capital Management, L.P. | Institution | 3.096.336 | 4,90% | US$ 9,13M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 3.096.336 | 4,90% | US$ 9,13M | 2026-03-13 |
| Takeda Pharmaceutical Company Limited | Institution | 1.824.977 | 2,89% | US$ 5,38M | 2025-09-30 |
| Vanguard Capital Management, LLC | Institution | 1.784.472 | 2,82% | US$ 5,26M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.638.770 | 2,59% | US$ 4,83M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 1.498.993 | 2,37% | US$ 4,42M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.226.310 | 1,94% | US$ 3,62M | 2026-03-31 |
| Decheng Capital Global Healthcare Fund (Master), LP | Institution | 1.161.598 | 1,84% | US$ 3,43M | 2024-09-30 |
| Spearhead Insurance Solutions Idf, Llc | Institution | 699.101 | 1,11% | US$ 2,06M | 2025-09-30 |
| Renaissance Technologies LLC | Institution | 656.964 | 1,04% | US$ 1,94M | 2026-03-31 |
| Diadema Partners LP | Institution | 433.844 | 0,69% | US$ 1,28M | 2026-03-31 |
| Hudson Bay Capital Management LP | Institution | 428.538 | 0,68% | US$ 1,26M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 378.813 | 0,60% | US$ 1,12M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 303.555 | 0,48% | US$ 895,49k | 2026-03-31 |
| Cantor Fitzgerald Asset Management | Institution | 262.643 | 0,42% | US$ 774,80k | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 246.173 | 0,39% | US$ 726,21k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 221.241 | 0,35% | US$ 652,66k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 189.530 | 0,30% | US$ 559,11k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 174.060 | 0,28% | US$ 513,48k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 158.733 | 0,25% | US$ 468,26k | 2026-03-31 |
| BlackRock, Inc. | Institution | 127.852 | 0,20% | US$ 377,16k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 115.535 | 0,18% | US$ 340,83k | 2026-03-31 |
| Persistent Asset Partners Limited | Institution | 110.117 | 0,17% | US$ 324,85k | 2026-03-31 |
| XTX Markets Limited | Institution | 103.105 | 0,16% | US$ 304,16k | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 93.211 | 0,15% | US$ 274,97k | 2026-03-31 |
| Northern Trust Global Investments | Institution | 70.158 | 0,11% | US$ 206,97k | 2026-03-31 |
| Marshall Wace LLP | Institution | 57.632 | 0,09% | US$ 170,01k | 2026-03-31 |
| AlphaCore Wealth Advisory, LLC | Institution | 52.345 | 0,08% | US$ 154,42k | 2026-03-31 |
| OMERS Administration Corporation | Institution | 50.037 | 0,08% | US$ 147,61k | 2026-03-31 |
| Quadrature Capital Limited | Institution | 28.760 | 0,05% | US$ 84,84k | 2026-03-31 |
| Tudor Investment Corporation | Institution | 20.100 | 0,03% | US$ 59,30k | 2026-03-31 |
| Morgan Stanley | Institution | 18.520 | 0,03% | US$ 54,63k | 2026-03-31 |