| Janus Henderson Group plc | Institution | 1.284.324 | 13,09% | US$ 79,08M | 2026-03-31 |
| Mr. Ian McDonald | Insider | 1.004.900 | 10,24% | US$ 61,87M | 2025-09-30 |
| Janus Henderson Biotech Innovation Master Fund Limited | Institution | 984.485 | 10,03% | US$ 60,61M | 2025-03-31 |
| Cormorant Asset Management, LP | Institution | 950.000 | 9,68% | US$ 58,49M | 2026-04-28 |
| Cormorant Global Healthcare Master Fund, LP | Institution | 950.000 | 9,68% | US$ 58,49M | 2026-04-28 |
| BlackRock, Inc. | Institution | 621.933 | 6,34% | US$ 38,29M | 2026-03-31 |
| Vivo Capital, LLC | Institution | 557.172 | 5,68% | US$ 34,31M | 2026-03-31 |
| Braidwell LP | Institution | 539.708 | 5,50% | US$ 33,23M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 504.645 | 5,14% | US$ 31,07M | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 495.743 | 5,05% | US$ 30,52M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 492.319 | 5,02% | US$ 30,31M | 2026-03-31 |
| Dr. Alan Kozikowski | Insider | 480.500 | 4,90% | US$ 29,58M | 2024-12-20 |
| Perceptive Life Sciences Master Fund, Ltd. | Institution | 449.290 | 4,58% | US$ 27,66M | 2025-12-31 |
| Driehaus Capital Management LLC | Institution | 432.515 | 4,41% | US$ 26,63M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 395.743 | 4,03% | US$ 24,37M | 2025-09-30 |
| Perceptive Advisors LLC | Institution | 377.544 | 3,85% | US$ 23,25M | 2026-03-31 |
| Commodore Capital Master LP | Institution | 351.848 | 3,59% | US$ 21,66M | 2024-12-31 |
| Balyasny Asset Management L.P. | Institution | 297.158 | 3,03% | US$ 18,30M | 2026-03-31 |
| Deerfield Management Company, L.P. | Institution | 283.000 | 2,88% | US$ 17,42M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 265.000 | 2,70% | US$ 16,32M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 220.000 | 2,24% | US$ 13,55M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 212.175 | 2,16% | US$ 13,06M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 206.427 | 2,10% | US$ 12,71M | 2025-03-31 |
| Ikarian Capital, LLC | Institution | 166.647 | 1,70% | US$ 10,26M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 136.677 | 1,39% | US$ 8,42M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 130.013 | 1,33% | US$ 8,00M | 2026-03-31 |
| Morgan Stanley | Institution | 127.360 | 1,30% | US$ 7,84M | 2026-03-31 |
| Seven Grand Managers LLC | Institution | 120.000 | 1,22% | US$ 7,39M | 2026-03-31 |
| Acuta Capital Partners, LLC | Institution | 111.996 | 1,14% | US$ 6,90M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 108.239 | 1,10% | US$ 6,66M | 2026-03-31 |
| Logos Global Master Fund, LP | Institution | 100.000 | 1,02% | US$ 6,16M | 2024-10-16 |
| Geode Capital Management, LLC | Institution | 88.716 | 0,90% | US$ 5,46M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 86.083 | 0,88% | US$ 5,30M | 2026-03-31 |
| The B Group, Inc. | Institution | 67.500 | 0,69% | US$ 4,16M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 60.482 | 0,62% | US$ 3,72M | 2026-03-31 |
| Dr. Jan Pedersen | Insider | 57.600 | 0,59% | US$ 3,55M | 2025-09-30 |
| Walleye Capital LLC | Institution | 53.706 | 0,55% | US$ 3,31M | 2026-03-31 |
| Millennium Management LLC | Institution | 52.832 | 0,54% | US$ 3,25M | 2026-03-31 |
| Vivo Opportunity Cayman Fund,L.P. | Institution | 52.527 | 0,54% | US$ 3,23M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 51.290 | 0,52% | US$ 3,16M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 50.027 | 0,51% | US$ 3,08M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 45.965 | 0,47% | US$ 2,83M | 2026-03-31 |
| Woodline Partners LP | Institution | 45.668 | 0,47% | US$ 2,81M | 2026-03-31 |
| Parkman Healthcare Partners LLC | Institution | 40.098 | 0,41% | US$ 2,47M | 2026-03-31 |