| FMR LLC | Institution | 9.045.481 | 14,70% | US$ 245,04M | 2026-03-31 |
| Fairmount Funds Management LLC | Institution | 8.713.000 | 14,16% | US$ 236,04M | 2026-03-31 |
| Fairmount Healthcare Fund II L.P. | Institution | 5.809.000 | 9,44% | US$ 157,37M | 2026-02-09 |
| Avoro Capital Advisors LLC | Institution | 3.783.000 | 6,15% | US$ 102,48M | 2026-03-31 |
| VR Management, LLC | Institution | 3.603.595 | 5,85% | US$ 97,62M | 2026-03-31 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 2.841.355 | 4,62% | US$ 76,97M | 2026-02-09 |
| Forbion Capital Partners B.V. | Institution | 2.441.000 | 3,97% | US$ 66,13M | 2026-03-31 |
| RA Capital Management, L.P. | Institution | 2.399.310 | 3,90% | US$ 65,00M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2.362.696 | 3,84% | US$ 64,01M | 2026-03-31 |
| Viking Global Investors LP | Institution | 2.311.082 | 3,75% | US$ 62,61M | 2026-03-31 |
| Bellevue Asset Management AG | Institution | 2.298.000 | 3,73% | US$ 62,25M | 2026-03-31 |
| Remedium Capital Partners, LLC | Institution | 2.045.473 | 3,32% | US$ 55,41M | 2026-03-31 |
| Commodore Capital LP | Institution | 1.939.000 | 3,15% | US$ 52,53M | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 1.525.000 | 2,48% | US$ 41,31M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.448.000 | 2,35% | US$ 39,23M | 2026-03-31 |
| Andreessen Horowitz LLC | Institution | 1.236.157 | 2,01% | US$ 33,49M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.223.000 | 1,99% | US$ 33,13M | 2026-03-31 |
| Point72 Asset Management, L.P. | Institution | 1.193.708 | 1,94% | US$ 32,34M | 2026-03-31 |
| Wellington Management Group LLP | Institution | 1.058.000 | 1,72% | US$ 28,66M | 2026-03-31 |
| Artal Group S.A. | Institution | 900.000 | 1,46% | US$ 24,38M | 2026-03-31 |
| Braidwell LP | Institution | 894.846 | 1,45% | US$ 24,24M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 692.909 | 1,13% | US$ 18,77M | 2026-02-09 |
| Vestal Point Capital, LP | Institution | 600.000 | 0,97% | US$ 16,25M | 2026-03-31 |
| Blackstone Alternative Asset Management L.P. | Institution | 503.522 | 0,82% | US$ 13,64M | 2026-03-31 |
| Millennium Management LLC | Institution | 471.646 | 0,77% | US$ 12,78M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 450.000 | 0,73% | US$ 12,19M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 335.710 | 0,55% | US$ 9,09M | 2026-03-31 |
| Ikarian Healthcare Master Fund, L.P. | Institution | 285.710 | 0,46% | US$ 7,74M | 2025-11-30 |
| Qube Research & Technologies Ltd | Institution | 282.436 | 0,46% | US$ 7,65M | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 279.000 | 0,45% | US$ 7,56M | 2026-03-31 |
| Nantahala Capital Management, LLC | Institution | 278.000 | 0,45% | US$ 7,53M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 241.126 | 0,39% | US$ 6,53M | 2026-03-31 |
| BlackRock, Inc. | Institution | 222.437 | 0,36% | US$ 6,03M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 201.847 | 0,33% | US$ 5,47M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 183.922 | 0,30% | US$ 4,98M | 2026-03-31 |
| Marshall Wace LLP | Institution | 169.818 | 0,28% | US$ 4,60M | 2026-03-31 |
| UBS Asset Management AG | Institution | 160.415 | 0,26% | US$ 4,35M | 2026-03-31 |