| Adage Capital Management, L.P. | Institution | 27.178.192 | 9,18% | US$ 435,94M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 26.066.805 | 8,81% | US$ 418,11M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 25.687.540 | 8,68% | US$ 412,03M | 2026-06-03 |
| Baker Bros. Advisors LP | Institution | 23.468.163 | 7,93% | US$ 376,43M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 23.425.713 | 7,92% | US$ 375,75M | 2026-04-15 |
| Averill Master Fund, Ltd. | Institution | 23.425.713 | 7,92% | US$ 375,75M | 2026-04-15 |
| Artisan Partners Limited Partnership | Institution | 22.825.885 | 7,71% | US$ 366,13M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 21.996.097 | 7,43% | US$ 352,82M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 21.282.929 | 7,19% | US$ 341,38M | 2026-01-12 |
| Artal Group S.A. | Institution | 19.310.005 | 6,53% | US$ 309,73M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 17.997.870 | 6,08% | US$ 288,69M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 15.459.843 | 5,22% | US$ 247,98M | 2026-01-29 |
| Vivo Capital, LLC | Institution | 13.337.845 | 4,51% | US$ 213,94M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 11.820.005 | 3,99% | US$ 189,59M | 2026-03-31 |
| Bpifrance Participations SA | Institution | 10.898.595 | 3,68% | US$ 174,81M | 2026-01-07 |
| The Goldman Sachs Group, Inc. | Institution | 7.165.123 | 2,42% | US$ 114,93M | 2025-11-10 |
| ADAR1 Capital Management, LLC | Institution | 5.064.330 | 1,71% | US$ 81,23M | 2026-03-31 |
| Syquant Capital SAS | Institution | 4.833.228 | 1,63% | US$ 77,52M | 2025-04-02 |
| Perceptive Advisors LLC | Institution | 4.821.955 | 1,63% | US$ 77,34M | 2026-03-31 |
| Yiheng Capital Management, L.P. | Institution | 4.132.210 | 1,40% | US$ 66,28M | 2026-03-31 |
| Braidwell LP | Institution | 3.899.300 | 1,32% | US$ 62,54M | 2024-12-31 |
| Patient Square Capital, LP | Institution | 3.467.670 | 1,17% | US$ 55,62M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 2.871.000 | 0,97% | US$ 46,05M | 2026-03-31 |
| Redmile Group, LLC | Institution | 2.456.700 | 0,83% | US$ 39,41M | 2026-03-31 |
| Braidwell Partners Master Fund LP | Institution | 2.393.815 | 0,81% | US$ 38,40M | 2024-12-31 |
| 667, L.P. | Institution | 2.185.234 | 0,74% | US$ 35,05M | 2026-01-12 |
| Duquesne Family Office LLC | Institution | 1.916.815 | 0,65% | US$ 30,75M | 2026-03-31 |
| Averill Madison Master Fund, Ltd. | Institution | 1.783.701 | 0,60% | US$ 28,61M | 2025-10-13 |
| BlackRock, Inc. | Institution | 1.777.979 | 0,60% | US$ 28,52M | 2026-05-31 |
| Millennium Management LLC | Institution | 1.594.795 | 0,54% | US$ 25,58M | 2026-03-31 |
| Vivo Opportunity Cayman Fund,L.P. | Institution | 1.517.840 | 0,51% | US$ 24,35M | 2026-03-31 |
| Atika Capital Management, LLC | Institution | 1.356.500 | 0,46% | US$ 21,76M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 1.325.000 | 0,45% | US$ 21,25M | 2026-03-31 |
| Avicenna Life Sci Master Fund Lp | Institution | 1.312.135 | 0,44% | US$ 21,05M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.167.145 | 0,39% | US$ 18,72M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1.157.085 | 0,39% | US$ 18,56M | 2026-03-31 |
| New York State Common Retirement Fund | Institution | 840.900 | 0,28% | US$ 13,49M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 817.005 | 0,28% | US$ 13,10M | 2026-03-31 |
| Morgan Stanley | Institution | 730.580 | 0,25% | US$ 11,72M | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 642.800 | 0,22% | US$ 10,31M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 525.000 | 0,18% | US$ 8,42M | 2026-03-31 |
| Dorsey, Wright & Associates, LLC | Institution | 512.750 | 0,17% | US$ 8,22M | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 512.500 | 0,17% | US$ 8,22M | 2026-03-31 |
| Envestnet Asset Management, Inc. | Institution | 478.570 | 0,16% | US$ 7,68M | 2026-03-31 |
| UBS Asset Management AG | Institution | 397.685 | 0,13% | US$ 6,38M | 2026-03-31 |
| Polymer Capital Management (HK) Limited | Institution | 322.500 | 0,11% | US$ 5,17M | 2026-03-31 |
| Diversify Wealth Management, LLC | Institution | 318.360 | 0,11% | US$ 5,11M | 2026-03-31 |