| Adage Capital Management, L.P. | Institution | 27.178.192 | 9,18% | US$ 427,51M | 2026-03-31 |
| MPM BioImpact LLC | Institution | 26.066.806 | 8,81% | US$ 410,03M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 25.139.882 | 8,50% | US$ 395,45M | 2026-06-05 |
| Baker Bros. Advisors LP | Institution | 23.468.163 | 7,93% | US$ 369,15M | 2026-03-31 |
| Suvretta Capital Management, LLC | Institution | 23.425.713 | 7,92% | US$ 368,49M | 2026-04-15 |
| Averill Master Fund, Ltd. | Institution | 23.425.713 | 7,92% | US$ 368,49M | 2026-04-15 |
| Artisan Partners Limited Partnership | Institution | 22.825.885 | 7,71% | US$ 359,05M | 2026-03-31 |
| Adage Capital Partners, L.P. | Institution | 21.996.097 | 7,43% | US$ 346,00M | 2026-03-31 |
| Baker Brothers Life Sciences, L.P. | Institution | 21.282.929 | 7,19% | US$ 334,78M | 2026-01-12 |
| Artal Group S.A. | Institution | 19.310.005 | 6,53% | US$ 303,75M | 2026-03-31 |
| Invus Public Equities, L.P. | Institution | 17.997.870 | 6,08% | US$ 283,11M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 15.459.843 | 5,22% | US$ 243,18M | 2026-01-29 |
| Vivo Capital, LLC | Institution | 13.337.845 | 4,51% | US$ 209,80M | 2026-03-31 |
| Vivo Opportunity Fund Holdings, L.P | Institution | 11.820.005 | 3,99% | US$ 185,93M | 2026-03-31 |
| Bpifrance Participations SA | Institution | 10.898.595 | 3,68% | US$ 171,43M | 2026-01-07 |
| The Goldman Sachs Group, Inc. | Institution | 7.165.123 | 2,42% | US$ 112,71M | 2025-11-10 |
| ADAR1 Capital Management, LLC | Institution | 5.064.330 | 1,71% | US$ 79,66M | 2026-03-31 |
| Syquant Capital SAS | Institution | 4.833.228 | 1,63% | US$ 76,03M | 2025-04-02 |
| Perceptive Advisors LLC | Institution | 4.821.955 | 1,63% | US$ 75,85M | 2026-03-31 |
| Yiheng Capital Management, L.P. | Institution | 4.132.210 | 1,40% | US$ 65,00M | 2026-03-31 |
| Braidwell LP | Institution | 3.899.300 | 1,32% | US$ 61,34M | 2024-12-31 |
| Patient Square Capital, LP | Institution | 3.467.670 | 1,17% | US$ 54,55M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 2.871.000 | 0,97% | US$ 45,16M | 2026-03-31 |
| Redmile Group, LLC | Institution | 2.456.700 | 0,83% | US$ 38,64M | 2026-03-31 |
| Braidwell Partners Master Fund LP | Institution | 2.393.815 | 0,81% | US$ 37,65M | 2024-12-31 |
| 667, L.P. | Institution | 2.185.234 | 0,74% | US$ 34,37M | 2026-01-12 |
| Duquesne Family Office LLC | Institution | 1.916.815 | 0,65% | US$ 30,15M | 2026-03-31 |
| Averill Madison Master Fund, Ltd. | Institution | 1.783.701 | 0,60% | US$ 28,06M | 2025-10-13 |
| BlackRock, Inc. | Institution | 1.777.979 | 0,60% | US$ 27,97M | 2026-05-31 |
| Millennium Management LLC | Institution | 1.594.795 | 0,54% | US$ 25,09M | 2026-03-31 |
| Vivo Opportunity Cayman Fund,L.P. | Institution | 1.517.840 | 0,51% | US$ 23,88M | 2026-03-31 |
| Atika Capital Management, LLC | Institution | 1.356.500 | 0,46% | US$ 21,34M | 2026-03-31 |
| Elmind Capital, L.P. | Institution | 1.325.000 | 0,45% | US$ 20,84M | 2026-03-31 |
| Avicenna Life Sci Master Fund Lp | Institution | 1.312.135 | 0,44% | US$ 20,64M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 1.167.145 | 0,39% | US$ 18,36M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 1.157.085 | 0,39% | US$ 18,20M | 2026-03-31 |
| New York State Common Retirement Fund | Institution | 840.900 | 0,28% | US$ 13,23M | 2026-03-31 |
| Boothbay Fund Management, LLC | Institution | 817.005 | 0,28% | US$ 12,85M | 2026-03-31 |
| Morgan Stanley | Institution | 730.580 | 0,25% | US$ 11,49M | 2026-03-31 |
| Russell Investment Management, LLC | Institution | 642.800 | 0,22% | US$ 10,11M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 525.000 | 0,18% | US$ 8,26M | 2026-03-31 |
| Dorsey, Wright & Associates, LLC | Institution | 512.750 | 0,17% | US$ 8,07M | 2026-03-31 |
| Ishara Investments, L.P. | Institution | 512.500 | 0,17% | US$ 8,06M | 2026-03-31 |
| Envestnet Asset Management, Inc. | Institution | 478.570 | 0,16% | US$ 7,53M | 2026-03-31 |
| UBS Asset Management AG | Institution | 397.685 | 0,13% | US$ 6,26M | 2026-03-31 |
| Polymer Capital Management (HK) Limited | Institution | 322.500 | 0,11% | US$ 5,07M | 2026-03-31 |
| Diversify Wealth Management, LLC | Institution | 318.360 | 0,11% | US$ 5,01M | 2026-03-31 |