| MPM BioImpact LLC | Institution | 10.679.391 | 11,62% | US$ 7,48M | 2026-03-31 |
| Deep Track Capital, LP | Institution | 7.419.355 | 8,08% | US$ 5,19M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 7.419.355 | 8,08% | US$ 5,19M | 2025-03-31 |
| Nextech Invest Ltd. | Institution | 7.419.355 | 8,08% | US$ 5,19M | 2026-03-31 |
| Avidity Private Master Fund I LP | Institution | 7.364.795 | 8,02% | US$ 5,16M | 2026-03-31 |
| Soleus Capital Master Fund, L.P. | Institution | 6.963.141 | 7,58% | US$ 4,87M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 6.963.141 | 7,58% | US$ 4,87M | 2026-03-31 |
| Octagon Capital Advisors LP | Institution | 5.250.000 | 5,71% | US$ 3,68M | 2026-03-31 |
| Octagon Investments Master Fund LP | Institution | 5.250.000 | 5,71% | US$ 3,68M | 2026-03-31 |
| CHI Advisors LLC | Institution | 5.089.015 | 5,54% | US$ 3,56M | 2026-03-31 |
| Avidity Partners Management, L.P. | Institution | 4.998.267 | 5,44% | US$ 3,50M | 2026-03-31 |
| Avidity Master Fund LP | Institution | 4.510.100 | 4,91% | US$ 3,16M | 2025-09-30 |
| Franklin Resources, Inc. | Institution | 3.803.338 | 4,14% | US$ 2,66M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.431.953 | 3,74% | US$ 2,40M | 2026-03-31 |
| Biomedical Value Fund | Institution | 3.044.412 | 3,31% | US$ 2,13M | 2024-12-31 |
| Marshall Wace LLP | Institution | 2.948.441 | 3,21% | US$ 2,06M | 2026-03-31 |
| TCG Crossover Management, LLC | Institution | 2.682.696 | 2,92% | US$ 1,88M | 2026-03-31 |
| Great Point Partners, LLC | Institution | 2.238.496 | 2,44% | US$ 1,57M | 2026-03-31 |
| Biomedical Offshore Value Fund, LTD. | Institution | 1.639.299 | 1,78% | US$ 1,15M | 2024-12-31 |
| Millennium Management LLC | Institution | 1.424.374 | 1,55% | US$ 997,06k | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 1.100.000 | 1,20% | US$ 770,00k | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.093.894 | 1,19% | US$ 765,73k | 2026-03-31 |
| Adage Capital Management, L.P. | Institution | 1.000.000 | 1,09% | US$ 700,00k | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 917.922 | 1,00% | US$ 642,55k | 2026-03-31 |
| BlackRock, Inc. | Institution | 846.696 | 0,92% | US$ 592,69k | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 603.767 | 0,66% | US$ 422,64k | 2026-03-31 |
| Cormorant Asset Management, LP | Institution | 529.550 | 0,58% | US$ 370,69k | 2026-03-31 |
| Jane Street Group, LLC | Institution | 436.931 | 0,48% | US$ 305,85k | 2026-03-31 |
| ADAR1 Capital Management, LLC | Institution | 351.094 | 0,38% | US$ 245,77k | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 341.344 | 0,37% | US$ 238,94k | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 287.299 | 0,31% | US$ 201,11k | 2026-03-31 |
| Woodline Partners LP | Institution | 250.088 | 0,27% | US$ 175,06k | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 233.507 | 0,25% | US$ 163,45k | 2026-03-31 |
| Seven Fleet Capital Management LP | Institution | 190.785 | 0,21% | US$ 133,55k | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 182.999 | 0,20% | US$ 128,10k | 2026-03-31 |
| Citadel Advisors LLC | Institution | 140.017 | 0,15% | US$ 98,01k | 2026-03-31 |
| HighTower Advisors, LLC | Institution | 126.152 | 0,14% | US$ 88,31k | 2026-03-31 |
| Bank of America Corporation | Institution | 114.888 | 0,13% | US$ 80,42k | 2026-03-31 |
| Pathstone Family Office, LLC | Institution | 110.244 | 0,12% | US$ 77,17k | 2026-03-31 |
| Hudson River Trading LLC | Institution | 104.973 | 0,11% | US$ 73,48k | 2026-03-31 |
| Mill Creek Capital Advisors, LLC | Institution | 104.631 | 0,11% | US$ 73,24k | 2026-03-31 |