| Deep Track Capital, LP | Institution | 12.161.496 | 9,01% | US$ 161,63M | 2026-03-31 |
| RTW Investments, LP | Institution | 10.632.390 | 7,88% | US$ 141,30M | 2026-03-31 |
| Deep Track Biotechnology Master Fund, Ltd | Institution | 9.274.589 | 6,87% | US$ 123,26M | 2025-01-10 |
| Marshall Wace LLP | Institution | 4.038.335 | 2,99% | US$ 53,67M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 4.002.200 | 2,97% | US$ 53,19M | 2026-03-31 |
| BIT Capital GmbH | Institution | 3.491.234 | 2,59% | US$ 46,40M | 2026-03-31 |
| ARK Investment Management LLC | Institution | 3.301.050 | 2,45% | US$ 43,87M | 2026-03-31 |
| Millennium Management LLC | Institution | 3.138.522 | 2,33% | US$ 41,71M | 2026-03-31 |
| GMT Capital Corp. | Institution | 3.078.536 | 2,28% | US$ 40,91M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 2.583.499 | 1,91% | US$ 34,33M | 2026-03-31 |
| Dafna Capital Management, LLC | Institution | 2.418.882 | 1,79% | US$ 32,15M | 2026-03-31 |
| Baker Bros. Advisors LP | Institution | 2.344.720 | 1,74% | US$ 31,16M | 2026-03-31 |
| Eagle Health Investments LP | Institution | 2.060.427 | 1,53% | US$ 27,38M | 2026-03-31 |
| Nextbio Capital Management Lp | Institution | 2.021.407 | 1,50% | US$ 26,86M | 2026-03-31 |
| Integrated Core Strategies (US) LLC | Institution | 1.954.896 | 1,45% | US$ 25,98M | 2025-03-31 |
| UBS Asset Management AG | Institution | 1.855.070 | 1,37% | US$ 24,65M | 2026-03-31 |
| Caption Management, LLC | Institution | 1.610.130 | 1,19% | US$ 21,40M | 2026-03-31 |
| Sio Capital Management, LLC | Institution | 1.506.525 | 1,12% | US$ 20,02M | 2026-03-31 |
| Heights Capital Management, Inc. | Institution | 1.492.415 | 1,11% | US$ 19,83M | 2026-03-31 |
| Jefferies Financial Group Inc. | Institution | 1.467.362 | 1,09% | US$ 19,50M | 2026-03-31 |
| Aisling Capital Management LP | Institution | 1.432.336 | 1,06% | US$ 19,04M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.398.361 | 1,04% | US$ 18,58M | 2026-03-31 |
| PFM Health Sciences, LP | Institution | 1.367.099 | 1,01% | US$ 18,17M | 2026-03-31 |
| Morgan Stanley | Institution | 1.205.887 | 0,89% | US$ 16,03M | 2026-03-31 |
| Paradigm BioCapital International Fund Ltd. | Institution | 1.160.000 | 0,86% | US$ 15,42M | 2024-09-30 |
| OrbiMed Advisors LLC | Institution | 1.150.646 | 0,85% | US$ 15,29M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.108.483 | 0,82% | US$ 14,73M | 2026-03-31 |
| Ally Bridge Group | Institution | 1.045.000 | 0,77% | US$ 13,89M | 2026-03-31 |
| Alyeska Investment Group, L.P. | Institution | 1.000.000 | 0,74% | US$ 13,29M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 948.554 | 0,70% | US$ 12,61M | 2026-03-31 |
| CHI Advisors LLC | Institution | 904.504 | 0,67% | US$ 12,02M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 865.354 | 0,64% | US$ 11,50M | 2026-03-31 |
| Creek Drive Management Group LLC | Institution | 825.000 | 0,61% | US$ 10,96M | 2026-03-31 |
| Kalehua Capital Management LLC | Institution | 819.692 | 0,61% | US$ 10,89M | 2026-03-31 |
| BlackRock, Inc. | Institution | 683.241 | 0,51% | US$ 9,08M | 2026-03-31 |
| Eversept Partners, L.P. | Institution | 677.924 | 0,50% | US$ 9,01M | 2026-03-31 |
| Ikarian Capital, LLC | Institution | 675.000 | 0,50% | US$ 8,97M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 582.997 | 0,43% | US$ 7,75M | 2026-03-31 |
| Columbia Management Investment Advisers, LLC | Institution | 570.496 | 0,42% | US$ 7,58M | 2026-03-31 |
| Parkman Healthcare Partners LLC | Institution | 554.411 | 0,41% | US$ 7,37M | 2026-03-31 |
| Hennion & Walsh Asset Management, Inc. | Institution | 487.674 | 0,36% | US$ 6,48M | 2026-03-31 |
| Leap Investments LP | Institution | 455.000 | 0,34% | US$ 6,05M | 2026-03-31 |
| Centerbook Partners LP | Institution | 409.237 | 0,30% | US$ 5,44M | 2026-03-31 |
| Royce & Associates, LP | Institution | 382.086 | 0,28% | US$ 5,08M | 2026-03-31 |
| Birchview Capital, LP | Institution | 375.000 | 0,28% | US$ 4,98M | 2026-03-31 |