| Sirenia Capital Management LP | Institution | 9.335.000 | 8,47% | US$ 38,93M | 2026-03-31 |
| Morgan Stanley | Institution | 9.066.530 | 8,23% | US$ 37,81M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 8.477.647 | 7,69% | US$ 35,35M | 2025-10-17 |
| RA Capital Management, L.P. | Institution | 8.000.000 | 7,26% | US$ 33,36M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 8.000.000 | 7,26% | US$ 33,36M | 2025-10-17 |
| Bain Capital Life Sciences Investors, LLC | Institution | 7.171.910 | 6,51% | US$ 29,91M | 2026-03-31 |
| Lynx1 Capital Management LP | Institution | 6.998.902 | 6,35% | US$ 29,19M | 2026-03-31 |
| Squadron Master Fund LP | Institution | 5.550.000 | 5,04% | US$ 23,14M | 2026-05-12 |
| Squadron Capital Management Llc | Institution | 5.550.000 | 5,04% | US$ 23,14M | 2026-05-12 |
| Betta Pharmaceuticals Co., Ltd. | Institution | 4.874.550 | 4,42% | US$ 20,33M | 2025-04-22 |
| Wasatch Advisors LP | Institution | 4.581.761 | 4,16% | US$ 19,11M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.861.852 | 3,51% | US$ 16,10M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 3.803.942 | 3,45% | US$ 15,86M | 2026-03-31 |
| Soleus Capital Master Fund, L.P. | Institution | 3.553.949 | 3,23% | US$ 14,82M | 2025-12-31 |
| JPMorgan Chase & Co. | Institution | 3.223.054 | 2,93% | US$ 13,44M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 3.035.634 | 2,76% | US$ 12,66M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.511.015 | 2,28% | US$ 10,47M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 2.461.815 | 2,23% | US$ 10,27M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 2.361.192 | 2,14% | US$ 9,85M | 2026-03-31 |
| Bank of America Corporation | Institution | 2.163.840 | 1,96% | US$ 9,02M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.048.526 | 1,86% | US$ 8,54M | 2026-03-31 |
| BCLS II Equity Opportunities, LP | Institution | 2.020.000 | 1,83% | US$ 8,42M | 2025-10-17 |
| Silverarc Capital Management, LLC | Institution | 1.911.785 | 1,74% | US$ 7,97M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.890.914 | 1,72% | US$ 7,89M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.547.119 | 1,40% | US$ 6,45M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.393.342 | 1,26% | US$ 5,81M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 1.246.896 | 1,13% | US$ 5,20M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1.060.331 | 0,96% | US$ 4,42M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 951.043 | 0,86% | US$ 3,97M | 2026-03-31 |
| Wells Fargo & Company | Institution | 867.911 | 0,79% | US$ 3,62M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 856.353 | 0,78% | US$ 3,57M | 2026-03-31 |
| Congress Asset Management Company, LLP | Institution | 830.624 | 0,75% | US$ 3,46M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 752.114 | 0,68% | US$ 3,14M | 2026-03-31 |
| Mr. Bruce Downey | Insider | 489.542 | 0,44% | US$ 2,04M | 2025-04-22 |
| Vanguard Fiduciary Trust Company | Institution | 484.131 | 0,44% | US$ 2,02M | 2026-03-31 |
| Jackson National Asset Management, LLC | Institution | 471.626 | 0,43% | US$ 1,97M | 2026-03-31 |
| StemPoint Capital LP | Institution | 453.236 | 0,41% | US$ 1,89M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 452.228 | 0,41% | US$ 1,89M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 442.518 | 0,40% | US$ 1,85M | 2026-03-31 |
| L1 Group Limited | Institution | 384.766 | 0,35% | US$ 1,60M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 382.973 | 0,35% | US$ 1,60M | 2026-03-31 |