| Morgan Stanley | Institution | 9.066.530 | 8,20% | US$ 39,44M | 2026-03-31 |
| Point72 Associates, LLC | Institution | 8.477.647 | 7,67% | US$ 36,88M | 2025-10-17 |
| RA Capital Management, L.P. | Institution | 8.000.000 | 7,24% | US$ 34,80M | 2026-03-31 |
| RA Capital Healthcare Fund, L.P. | Institution | 8.000.000 | 7,24% | US$ 34,80M | 2025-10-17 |
| Bain Capital Life Sciences Investors, LLC | Institution | 7.171.910 | 6,49% | US$ 31,20M | 2026-03-31 |
| Lynx1 Capital Management LP | Institution | 6.998.902 | 6,33% | US$ 30,45M | 2026-03-31 |
| Squadron Capital Management Llc | Institution | 5.550.000 | 5,02% | US$ 24,14M | 2026-05-12 |
| Wasatch Advisors LP | Institution | 4.581.761 | 4,14% | US$ 19,93M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 3.861.852 | 3,49% | US$ 16,80M | 2026-03-31 |
| Soleus Capital Management, L.P. | Institution | 3.803.942 | 3,44% | US$ 16,55M | 2026-03-31 |
| Soleus Capital Master Fund, L.P. | Institution | 3.553.949 | 3,21% | US$ 15,46M | 2025-12-31 |
| JPMorgan Chase & Co. | Institution | 3.223.054 | 2,92% | US$ 14,02M | 2026-03-31 |
| Two Sigma Investments, LP | Institution | 3.035.634 | 2,75% | US$ 13,21M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 2.511.015 | 2,27% | US$ 10,92M | 2026-03-31 |
| Renaissance Technologies LLC | Institution | 2.461.815 | 2,23% | US$ 10,71M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 2.361.192 | 2,14% | US$ 10,27M | 2026-03-31 |
| Bank of America Corporation | Institution | 2.163.840 | 1,96% | US$ 9,41M | 2026-03-31 |
| BlackRock, Inc. | Institution | 2.048.526 | 1,85% | US$ 8,91M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 1.911.785 | 1,73% | US$ 8,32M | 2026-03-31 |
| Acadian Asset Management LLC | Institution | 1.890.914 | 1,71% | US$ 8,23M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 1.547.119 | 1,40% | US$ 6,73M | 2026-03-31 |
| Millennium Management LLC | Institution | 1.393.342 | 1,26% | US$ 6,06M | 2026-03-31 |
| Jane Street Group, LLC | Institution | 1.246.896 | 1,13% | US$ 5,42M | 2026-03-31 |
| D. E. Shaw & Co., L.P. | Institution | 1.060.331 | 0,96% | US$ 4,61M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 951.043 | 0,86% | US$ 4,14M | 2026-03-31 |
| Wells Fargo & Company | Institution | 867.911 | 0,78% | US$ 3,78M | 2026-03-31 |
| OrbiMed Advisors LLC | Institution | 856.353 | 0,77% | US$ 3,73M | 2026-03-31 |
| Congress Asset Management Company, LLP | Institution | 830.624 | 0,75% | US$ 3,61M | 2026-03-31 |
| Qube Research & Technologies Ltd | Institution | 752.114 | 0,68% | US$ 3,27M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 484.131 | 0,44% | US$ 2,11M | 2026-03-31 |
| Jackson National Asset Management, LLC | Institution | 471.626 | 0,43% | US$ 2,05M | 2026-03-31 |
| StemPoint Capital LP | Institution | 453.236 | 0,41% | US$ 1,97M | 2026-03-31 |
| Charles Schwab Investment Management, Inc. | Institution | 452.228 | 0,41% | US$ 1,97M | 2026-03-31 |
| Dimensional Fund Advisors LP | Institution | 442.518 | 0,40% | US$ 1,92M | 2026-03-31 |
| L1 Group Limited | Institution | 384.766 | 0,35% | US$ 1,67M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 382.973 | 0,35% | US$ 1,67M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 300.000 | 0,27% | US$ 1,31M | 2026-03-31 |
| Connor, Clark & Lunn Investment Management Ltd. | Institution | 277.183 | 0,25% | US$ 1,21M | 2026-03-31 |
| FMR LLC | Institution | 272.316 | 0,25% | US$ 1,18M | 2026-03-31 |