Statement of Changes in Beneficial Ownership (4)

FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).	UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES	OMB APPROVAL OMB Number: 3235-0287 Estimated average burden hours per response... 0.5
	Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

1. Name and Address of Reporting Person ^* MCGUIRE TERRANCE	2. Issuer Name and Ticker or Trading Symbol Arsanis, Inc. [ ASNS ]	5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __ X __ Director __ X __ 10% Owner _____ Officer (give title below) _____ Other (specify below)
(Last) (First) (Middle) C/O POLARIS PARTNERS, ONE MARINA PARK DRIVE, 10TH FLOOR	3. Date of Earliest Transaction (MM/DD/YYYY) 11/20/2017
(Street) BOSTON, MA 02210 (City) (State) (Zip)	4. If Amendment, Date Original Filed (MM/DD/YYYY)	6. Individual or Joint/Group Filing (Check Applicable Line) _ X _ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	3. Trans. Code (Instr. 8)		4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1.Title of Security (Instr. 3)	2. Trans. Date	2A. Deemed Execution Date, if any	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	11/20/2017		C		18848	A	⁽¹⁾	18848	I	See Footnotes ⁽²⁾ ⁽³⁾
Common Stock	11/20/2017		C		367	A	⁽¹⁾	367	I	See Footnote ⁽⁴⁾
Common Stock	11/20/2017		C		129	A	⁽¹⁾	129	I	See Footnote ⁽⁵⁾
Common Stock	11/20/2017		C		188	A	⁽¹⁾	188	I	See Footnote ⁽⁶⁾
Common Stock	11/20/2017		C		243385	A	⁽⁷⁾	262233	I	See Footnotes ⁽²⁾ ⁽³⁾
Common Stock	11/20/2017		C		4743	A	⁽⁷⁾	5110	I	See Footnote ⁽⁴⁾
Common Stock	11/20/2017		C		1667	A	⁽⁷⁾	1796	I	See Footnote ⁽⁵⁾
Common Stock	11/20/2017		C		2433	A	⁽⁷⁾	2621	I	See Footnote ⁽⁶⁾
Common Stock	11/20/2017		C		317376	A	⁽⁸⁾	579609	I	See Footnotes ⁽²⁾ ⁽³⁾
Common Stock	11/20/2017		C		6185	A	⁽⁸⁾	11295	I	See Footnote ⁽⁴⁾
Common Stock	11/20/2017		C		2173	A	⁽⁸⁾	3969	I	See Footnote ⁽⁵⁾
Common Stock	11/20/2017		C		3173	A	⁽⁸⁾	5794	I	See Footnote ⁽⁶⁾
Common Stock	11/20/2017		C		110312	A	⁽⁹⁾	689921	I	See Footnotes ⁽²⁾ ⁽³⁾
Common Stock	11/20/2017		C		2150	A	⁽⁹⁾	13445	I	See Footnote ⁽⁴⁾
Common Stock	11/20/2017		C		755	A	⁽⁹⁾	4724	I	See Footnote ⁽⁵⁾
Common Stock	11/20/2017		C		1102	A	⁽⁹⁾	6896	I	See Footnote ⁽⁶⁾
Common Stock	11/20/2017		C		631041	A	⁽¹⁰⁾	1320962	I	See Footnotes ⁽²⁾ ⁽³⁾
Common Stock	11/20/2017		C		12298	A	⁽¹⁰⁾	25743	I	See Footnote ⁽⁴⁾
Common Stock	11/20/2017		C		4322	A	⁽¹⁰⁾	9046	I	See Footnote ⁽⁵⁾
Common Stock	11/20/2017		C		6310	A	⁽¹⁰⁾	13206	I	See Footnote ⁽⁶⁾
Common Stock	11/20/2017		P		482467	A	$10.00	1803429	I	See Footnotes ⁽²⁾ ⁽³⁾
Common Stock	11/20/2017		P		9403	A	$10.00	35146	I	See Footnote ⁽⁴⁾
Common Stock	11/20/2017		P		3305	A	$10.00	12351	I	See Footnote ⁽⁵⁾
Common Stock	11/20/2017		P		4825	A	$10.00	18031	I	See Footnote ⁽⁶⁾

*Table II - Derivative Securities Beneficially Owned ( e.g.* , puts, calls, warrants, options, convertible securities)**
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	4. Trans. Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivate Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Trans. Date	3A. Deemed Execution Date, if any	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)			11. Nature of Indirect Beneficial Ownership (Instr. 4)
Series A-1 Convertible Preferred Stock	⁽¹⁾	11/20/2017		C			64329	⁽¹⁾	⁽¹⁾	Common Stock	18848	$0.00	0	I	See Footnotes ⁽²⁾ ⁽³⁾
Series A-1 Convertible Preferred Stock	⁽¹⁾	11/20/2017		C			1254	⁽¹⁾	⁽¹⁾	Common Stock	367	$0.00	0	I	See Footnote ⁽⁴⁾
Series A-1 Convertible Preferred Stock	⁽¹⁾	11/20/2017		C			441	⁽¹⁾	⁽¹⁾	Common Stock	129	$0.00	0	I	See Footnote ⁽⁵⁾
Series A-1 Convertible Preferred Stock	⁽¹⁾	11/20/2017		C			643	⁽¹⁾	⁽¹⁾	Common Stock	188	$0.00	0	I	See Footnote ⁽⁶⁾
Series A-2 Convertible Preferred Stock	⁽⁷⁾	11/20/2017		C			680130	⁽⁷⁾	⁽⁷⁾	Common Stock	243385	$0.00	0	I	See Footnotes ⁽²⁾ ⁽³⁾
Series A-2 Convertible Preferred Stock	⁽⁷⁾	11/20/2017		C			13256	⁽⁷⁾	⁽⁷⁾	Common Stock	4743	$0.00	0	I	See Footnote ⁽⁴⁾
Series A-2 Convertible Preferred Stock	⁽⁷⁾	11/20/2017		C			4659	⁽⁷⁾	⁽⁷⁾	Common Stock	1667	$0.00	0	I	See Footnote ⁽⁵⁾
Series A-2 Convertible Preferred Stock	⁽⁷⁾	11/20/2017		C			6801	⁽⁷⁾	⁽⁷⁾	Common Stock	2433	$0.00	0	I	See Footnote ⁽⁶⁾
Series B Convertible Preferred Stock	⁽⁸⁾	11/20/2017		C			710817	⁽⁸⁾	⁽⁸⁾	Common Stock	317376	$0.00	0	I	See Footnotes ⁽²⁾ ⁽³⁾
Series B Convertible Preferred Stock	⁽⁸⁾	11/20/2017		C			13854	⁽⁸⁾	⁽⁸⁾	Common Stock	6185	$0.00	0	I	See Footnote ⁽⁴⁾
Series B Convertible Preferred Stock	⁽⁸⁾	11/20/2017		C			4869	⁽⁸⁾	⁽⁸⁾	Common Stock	2173	$0.00	0	I	See Footnote ⁽⁵⁾
Series B Convertible Preferred Stock	⁽⁸⁾	11/20/2017		C			7108	⁽⁸⁾	⁽⁸⁾	Common Stock	3173	$0.00	0	I	See Footnote ⁽⁶⁾
Series C Convertible Preferred Stock	⁽⁹⁾	11/20/2017		C			221638	⁽⁹⁾	⁽⁹⁾	Common Stock	110312	$0.00	0	I	See Footnotes ⁽²⁾ ⁽³⁾
Series C Convertible Preferred Stock	⁽⁹⁾	11/20/2017		C			4315	⁽⁹⁾	⁽⁹⁾	Common Stock	2150	$0.00	0	I	See Footnote ⁽⁴⁾
Series C Convertible Preferred Stock	⁽⁹⁾	11/20/2017		C			1516	⁽⁹⁾	⁽⁹⁾	Common Stock	755	$0.00	0	I	See Footnote ⁽⁵⁾
Series C Convertible Preferred Stock	⁽⁹⁾	11/20/2017		C			2213	⁽⁹⁾	⁽⁹⁾	Common Stock	1102	$0.00	0	I	See Footnote ⁽⁶⁾
Series D Convertible Preferred Stock	⁽¹⁰⁾	11/20/2017		C			2153746	⁽¹⁰⁾	⁽¹⁰⁾	Common Stock	631041	$0.00	0	I	See Footnotes ⁽²⁾ ⁽³⁾
Series D Convertible Preferred Stock	⁽¹⁰⁾	11/20/2017		C			41976	⁽¹⁰⁾	⁽¹⁰⁾	Common Stock	12298	$0.00	0	I	See Footnote ⁽⁴⁾
Series D Convertible Preferred Stock	⁽¹⁰⁾	11/20/2017		C			14752	⁽¹⁰⁾	⁽¹⁰⁾	Common Stock	4322	$0.00	0	I	See Footnote ⁽⁵⁾
Series D Convertible Preferred Stock	⁽¹⁰⁾	11/20/2017		C			21537	⁽¹⁰⁾	⁽¹⁰⁾	Common Stock	6310	$0.00	0	I	See Footnote ⁽⁶⁾

Explanation of Responses:
(1)	The Series A-1 Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-1 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(2)	These shares are owned directly by Polaris Venture Partners V, L.P. ("Polaris V"), whose general partner is Polaris Venture Management Co. V, L.L.C. ("Polaris Management"). Each of Jonathan A. Flint ("Flint") and the Reporting Person, are the managing members of Polaris Management and may each be deemed to share voting and dispositive power with respect to the shares held by each of Polaris V, Polaris Venture Partners Entrepreneurs' Fund V, L.P. ("Polaris Entrepreneurs' V"), Polaris Venture Partners Founders' Fund V, L.P. ("Polaris Founders' V") and Polaris Venture Partners Special Founders' Fund V, L.P. ("Polaris Special Founders' V", and together with Polaris V, Polaris Entrepreneurs' V and Polaris Founders' V, the "Polaris V Funds").
(3)	(Continued from footnote 2) Polaris Management may be deemed to have sole power to vote and dispose of the shares held by the Polaris V Funds. Each of Flint, the Reporting Person and Polaris Management disclaims beneficial ownership of these securities and this report shall not be deemed to be an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or any other purpose, except to the extent of their respective pecuniary interests therein.
(4)	These shares are owned directly by Polaris Entrepreneurs' V, whose general partner is Polaris Management. Each of Flint and the Reporting Person are the managing members of Polaris Management and may each be deemed to share voting and dispositive power over the shares held by each of the Polaris V Funds. Polaris Management may be deemed to have sole power to vote and dispose of the shares held by the Polaris V Funds. Each of Flint, the Reporting Person and Polaris Management disclaims beneficial ownership of these securities and this report shall not be deemed to be an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or any other purpose, except to the extent of their respective pecuniary interests therein.
(5)	These shares are owned directly by Polaris Founders' V, whose general partner is Polaris Management. Each of Flint and the Reporting Person are the managing members of Polaris Management and may each be deemed to share voting and dispositive power over the shares held by each of the Polaris V Funds. Polaris Management may be deemed to have sole power to vote and dispose of the shares held by the Polaris V Funds. Each of Flint, the Reporting Person and Polaris Management disclaims beneficial ownership of these securities and this report shall not be deemed to be an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or any other purpose, except to the extent of their respective pecuniary interests therein.
(6)	These shares are owned directly by Polaris Special Founders' V, whose general partner is Polaris Management. Each of Flint and the Reporting Person are the managing members of Polaris Management and, may each be deemed to share voting and dispositive power over the shares held by each of the Polaris V Funds. Polaris Management may be deemed to have sole power to vote and dispose of the shares held by the Polaris V Funds. Each of Flint, the Reporting Person and Polaris Management disclaims beneficial ownership of these securities and this report shall not be deemed to be an admission that any of them is the beneficial owner of such securities for purposes of Section 16 or any other purpose, except to the extent of their respective pecuniary interests therein.
(7)	The Series A-2 Convertible Preferred Stock converted into Common Stock on a 0.35785-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series A-2 Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(8)	The Series B Convertible Preferred Stock converted into Common Stock on a 0.44650-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series B Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(9)	The Series C Convertible Preferred Stock converted into Common Stock on a 0.49832-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series C Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.
(10)	The Series D Convertible Preferred Stock converted into Common Stock on a 0.29300-for-one basis upon the closing of the Issuer's initial public offering without payment of consideration. The Series D Convertible Preferred Stock was convertible at any time at the holder's election and automatically upon the closing at the Issuer's initial public offering. The shares had no expiration date.

Reporting Owners
Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
MCGUIRE TERRANCE C/O POLARIS PARTNERS ONE MARINA PARK DRIVE, 10TH FLOOR BOSTON, MA 02210	X	X

Signatures
/s/ Mike Gray, attorney-in-fact		11/20/2017
^** Signature of Reporting Person		Date

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:	File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

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