| T. Rowe Price Group, Inc. | Institution | 11.444.136 | 15,27% | US$ 1,52B | 2026-03-31 |
| FMR LLC | Institution | 9.262.288 | 12,36% | US$ 1,23B | 2026-03-31 |
| VR Management, LLC | Institution | 8.493.321 | 11,33% | US$ 1,13B | 2026-04-01 |
| Fairmount Funds Management LLC | Institution | 6.713.519 | 8,96% | US$ 891,35M | 2026-06-18 |
| Fairmount Healthcare Fund II L.P. | Institution | 6.713.519 | 8,96% | US$ 891,35M | 2026-06-18 |
| Venrock Healthcare Capital Partners EG, L.P. | Institution | 5.242.380 | 6,99% | US$ 696,03M | 2026-04-01 |
| Wellington Management Group LLP | Institution | 4.375.703 | 5,84% | US$ 580,96M | 2026-03-31 |
| BlackRock, Inc. | Institution | 4.085.651 | 5,45% | US$ 542,45M | 2026-03-31 |
| Venrock Healthcare Capital Partners III, L.P. | Institution | 2.955.394 | 3,94% | US$ 392,39M | 2026-04-01 |
| RTW Investments, LP | Institution | 2.782.097 | 3,71% | US$ 369,38M | 2026-03-31 |
| Vanguard Capital Management, LLC | Institution | 2.502.095 | 3,34% | US$ 332,20M | 2026-03-31 |
| Janus Henderson Group plc | Institution | 2.360.596 | 3,15% | US$ 313,42M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 2.162.964 | 2,89% | US$ 287,18M | 2026-03-31 |
| Driehaus Capital Management LLC | Institution | 1.920.800 | 2,56% | US$ 255,02M | 2026-03-31 |
| Perceptive Advisors LLC | Institution | 1.540.384 | 2,06% | US$ 204,52M | 2026-03-31 |
| Paradigm Biocapital Advisors LP | Institution | 1.348.243 | 1,80% | US$ 179,01M | 2026-03-31 |
| Affinity Asset Advisors, LLC | Institution | 1.284.926 | 1,71% | US$ 170,60M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.217.289 | 1,62% | US$ 161,62M | 2026-03-31 |
| UBS Asset Management AG | Institution | 1.200.680 | 1,60% | US$ 159,41M | 2026-03-31 |
| Vestal Point Capital, LP | Institution | 1.100.000 | 1,47% | US$ 146,05M | 2026-03-31 |
| Frontier Capital Management Co LLC | Institution | 1.064.483 | 1,42% | US$ 141,33M | 2026-03-31 |
| Dr. Michael Henderson | Insider | 1.015.987 | 1,36% | US$ 134,89M | 2026-06-22 |
| AllianceBernstein L.P. | Institution | 990.297 | 1,32% | US$ 131,48M | 2026-03-31 |
| Bank of America Corporation | Institution | 894.779 | 1,19% | US$ 118,80M | 2026-03-31 |
| Mercer Global Advisors Inc. | Institution | 831.428 | 1,11% | US$ 110,39M | 2026-03-31 |
| Citadel Advisors LLC | Institution | 598.902 | 0,80% | US$ 79,52M | 2026-03-31 |
| Jennison Associates LLC | Institution | 585.016 | 0,78% | US$ 77,67M | 2026-03-31 |
| Remedium Capital Partners, LLC | Institution | 583.591 | 0,78% | US$ 77,48M | 2026-03-31 |
| First Light Asset Management, LLC | Institution | 576.684 | 0,77% | US$ 76,57M | 2026-03-31 |
| Eventide Asset Management, LLC | Institution | 557.423 | 0,74% | US$ 74,01M | 2026-03-31 |
| Morgan Stanley | Institution | 544.771 | 0,73% | US$ 72,33M | 2026-03-31 |
| Polar Capital Holdings Plc | Institution | 539.177 | 0,72% | US$ 71,59M | 2026-03-31 |
| First Turn Management, LLC | Institution | 513.770 | 0,69% | US$ 68,21M | 2026-03-31 |