| Nantahala Capital Management, LLC | Institution | 5.013.052 | 8,80% | US$ 29,18M | 2026-03-31 |
| Nantahala Capital Partners Limited Partnership | Institution | 3.333.757 | 5,85% | US$ 19,40M | 2026-03-31 |
| BlackRock, Inc. | Institution | 3.195.530 | 5,61% | US$ 18,60M | 2026-03-31 |
| Aigh Capital Management, LLC | Institution | 3.100.000 | 5,44% | US$ 18,04M | 2026-03-31 |
| Cable Car Capital LLC | Institution | 3.007.329 | 5,28% | US$ 17,50M | 2026-03-31 |
| Daniel Kaufman | Insider | 2.943.629 | 5,16% | US$ 17,13M | 2026-03-26 |
| James Russell | Insider | 2.720.875 | 4,77% | US$ 15,84M | 2025-09-16 |
| Suvretta Capital Management, LLC | Institution | 2.676.000 | 4,70% | US$ 15,57M | 2026-03-31 |
| Averill Master Fund, Ltd. | Institution | 2.309.267 | 4,05% | US$ 13,44M | 2025-06-30 |
| Vanguard Capital Management, LLC | Institution | 2.164.851 | 3,80% | US$ 12,60M | 2026-03-31 |
| Dr. Vishwas Seshadri | Insider | 1.430.423 | 2,51% | US$ 8,33M | 2026-04-15 |
| Kennedy Capital Management LLC | Institution | 1.263.511 | 2,22% | US$ 7,35M | 2026-03-31 |
| Geode Capital Management, LLC | Institution | 1.209.797 | 2,12% | US$ 7,04M | 2026-03-31 |
| The Goldman Sachs Group, Inc. | Institution | 1.099.171 | 1,93% | US$ 6,40M | 2026-03-31 |
| State Street Global Advisors, Inc. | Institution | 957.328 | 1,68% | US$ 5,57M | 2026-03-31 |
| Nan Fung Trinity (HK) Limited | Institution | 956.770 | 1,68% | US$ 5,57M | 2026-03-31 |
| Propel Bio Management, LLC | Institution | 829.557 | 1,46% | US$ 4,83M | 2026-03-31 |
| AWM Investment Company Inc | Institution | 803.130 | 1,41% | US$ 4,67M | 2026-03-31 |
| 683 Capital Management, LLC | Institution | 770.000 | 1,35% | US$ 4,48M | 2026-03-31 |
| Stonepine Capital Management LLC | Institution | 746.587 | 1,31% | US$ 4,35M | 2026-03-31 |
| Silverarc Capital Management, LLC | Institution | 648.942 | 1,14% | US$ 3,78M | 2026-03-31 |
| J. Goldman & Co., L.P. | Institution | 640.530 | 1,12% | US$ 3,73M | 2026-03-31 |
| Diametric Capital, LP | Institution | 611.520 | 1,07% | US$ 3,56M | 2026-03-31 |
| Balyasny Asset Management L.P. | Institution | 589.847 | 1,03% | US$ 3,43M | 2026-03-31 |
| Mr. Joseph Vazzano | Insider | 567.775 | 1,00% | US$ 3,30M | 2026-04-15 |
| Citigroup Inc. | Institution | 522.445 | 0,92% | US$ 3,04M | 2026-03-31 |
| Simplify Asset Management Inc. | Institution | 507.988 | 0,89% | US$ 2,96M | 2026-03-31 |
| National Bank Investments Inc. | Institution | 500.000 | 0,88% | US$ 2,91M | 2026-03-31 |
| Knoll Capital Management | Institution | 485.515 | 0,85% | US$ 2,83M | 2026-03-31 |
| Dr. Brendan O’Malley | Insider | 451.134 | 0,79% | US$ 2,63M | 2026-04-15 |
| Northern Trust Global Investments | Institution | 435.973 | 0,76% | US$ 2,54M | 2026-03-31 |
| Susquehanna International Group, LLP | Institution | 432.370 | 0,76% | US$ 2,52M | 2026-03-31 |
| Millennium Management LLC | Institution | 425.426 | 0,75% | US$ 2,48M | 2026-03-31 |
| Tang Capital Management, LLC | Institution | 400.000 | 0,70% | US$ 2,33M | 2026-03-31 |
| Bank of America Corporation | Institution | 394.274 | 0,69% | US$ 2,29M | 2026-03-31 |
| Vanguard Fiduciary Trust Company | Institution | 339.515 | 0,60% | US$ 1,98M | 2026-03-31 |
| Dr. Madhav Vasanthavada | Insider | 313.071 | 0,55% | US$ 1,82M | 2026-05-11 |
| Morgan Stanley | Institution | 274.705 | 0,48% | US$ 1,60M | 2026-03-31 |
| Vanguard Portfolio Management, LLC | Institution | 270.976 | 0,48% | US$ 1,58M | 2026-03-31 |
| JPMorgan Chase & Co. | Institution | 266.497 | 0,47% | US$ 1,55M | 2026-03-31 |
| UBS Asset Management AG | Institution | 237.336 | 0,42% | US$ 1,38M | 2026-03-31 |